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Flashcards in General Deck (11)
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1

3 mechanisms of action

Direct-acting

Indirect-acting

Mixed-acting
(Direct activation + indirect release)

2

Direct-acting drugs

stimulate postsynaptic receptors

Selective vs. Nonselective

NOT reduced by pretreatment w/ Reserpine

3

Indirect-acting drugs

increase availability of NE or E
--releasing or displacing NE from sympathetic nerve varicosities
--Blocking transport of NE into neurons (i.e. cocaine)
--Blocking metabolizing enzymes (i.e. MAO or COMT)

ABOLISHED by pretreatment w/ Reserpine

Releasing agents vs. Cocaine, MAO, COMTI, etc.

4

Mixed-acting drugs

direct activation + indirect release

REDUCED by pretreatment w/ Reserpine

5

Selective Direct-acting adrenergic agonists

a1- phenylephrine
a2- clonidine
b1- dobutamine
b2- terbutaline

6

Non-selective Direct-acting adrenergic agonists

a--oxymetazoline
b--isoproterenol
a and b--epinephrine
a and b1--norepinephrine

7

Indirect-acting releasing agents

Tyramine
Amphetamines

8

Pretreatment w/ Reserpine...
Direct-acting drug

No effect,

may even increase b/c upregulation of receptors/enhancement of signalling pathway due to chronic treatment of reserpine

9

Pretreatment w/ Reserpine...
Indirect-acting

Abolished

10

Pretreatment w/ Reserpine...
Mixed-acting

Reduced

11

Tachyphalaxis

Rapid loss of pharmacological effect (happens faster than desensitization)