General Information

Question 0

Secondary Amyloidosis

Answer 0

Deposition of AA from precursor called serum amyloid associated protein SAA
Chronic inflammation: autoimmune disease, hodgkins, renal carcinoma

Question 1

Primary Amyloidosis

Answer 1

Deposition of amyloid fibrils derived from Ig lambda light chains AL
Produced by plasma cell and plasma cell disorder:
MM
waldenstrom
macroglobulinemia
other B cell proliferation disorder
Cardiac: heart failure and arrhythmia

Question 2

Alzheimer’s Amyloidosis

Answer 2

Amyloid beta protein
From APP C21
Bleed in >50 to rule out cerebral amyloid

Question 3

Amyloid deposition derived from calcitonin Acal

Answer 3

Medullary carcinoma of the thyroid, sheets of amyloid stroma, associated with Men 2Aand 2B

Question 4

DM and Amyloidosis

Answer 4

Type II shows deposition of amyloid in islets

Thought to be derived from insulin or glucagon and is called amylin or islet amyloid polypeptide.

Question 5

Dialysis associated Amyloid

Answer 5

Formed from Beta-2 micro globulin
A component of MHC I
In patient with ESRD and long term dialysis
Carpal tunnel or tether joint issue

Question 6

Heritable Amyloidosis

Answer 6

Heterogeneous group of disorders.

ATTR neurological and cardiac Amyloidosis due to transthyretin TTR or prealbumin gene mutation

Question 7

Senile Amyloidosis

Answer 7

Deposition of normal type of TTR in myocardium and other sites
Slow progression vs AL

Question 8

Congo red stain

Answer 8

Amyloidosis apple green birefringence

Question 9

Amyloid in cardiac

Answer 9

AL most common

Question 10

Kidney Amyloidosis

Answer 10

Glomeruli deposition
Dialysis
AL, beta2

Question 11

GI Amyloidosis

Answer 11

Tongue, macroglossia

Question 12

bence jone’s protein

Answer 12

light chain protein secrete in urine

amydosis