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Pharmacology > General Pharmacology > Flashcards

General Pharmacology Flashcards

1
Q

Substrate of p- gp

A

DILS- Digoxin
Itraconazole
Loperamide
Sofosbuvir

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2
Q

Pgp inducers

A

Rifampicin
Ritonavir
Cyp induced

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3
Q

P gp inhibitors

A

QUACKER- Quinidine
Verapamul
Amioderone
Cyclosporine
Ketoconazole
Erythromycin
Ritonavir

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4
Q

Drugs with very high first pass metabolism- not given orally

A

SELF-
steroids
Epinephrine
Lignocaine
Fentanyl

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5
Q

Drugs with high first pass metabolism- increased dose

A

PM VP SINGh
Propanolol
Morphine
Verapamil
Pethidine
Salbutamol
Imipramine
Nitroglycerine

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6
Q

Bioavailability

A

Fraction of drug absorbed in systemic circulation in unchanged form

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7
Q

Calculation of bio avail

A

Auc of conc time graph

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8
Q

Bioequivalence

A

If BA is less than 25% different then can be interchanged

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9
Q

Volume of distribution

A

Volume of plasma reqd to contain a drug in equal concentration

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10
Q

Vd calculation

A

Dose given/ initial plasma conc.

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11
Q

Loading dose formula

A

Vd×target conc.

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12
Q

Prodrugs

A

PLASMA
Prednisone
Levodopa
Acyclovir
Sulfasalazine
Mycophenolate
Ace inhibitor

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13
Q

Cyp enzyme inducers

A

GRAASS
Griseofulvin
Rifampicin
Anti epileptics
Alchohol
Smoking
St. John wort

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14
Q

Enzyme inhibitors

A

COKE In Gallon Alchohol
Cimetidine
Omeprazole
Ketoconazole
Erythromycin
Isoniazid
Grape fruit
Ciprofloxacin
Alchohol

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15
Q

Drugs with 0 order kinetics

A

WHATSAP
Warfarin
Heparin
Alchohol
Theophyline
Salicyclates
Aspirin
Phenytoin

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16
Q

Elimination formula

A

Clearance× plasma conc.

17
Q

Complete elimination of drugs takes place in __ half life

A

4-5

18
Q

Hit and run drugs

A

MOOGRA
MAO
Organophosphates
Omeprazole
Guanethidine
Reserpine
Aspirin

19
Q

Steady state conc - Css

A

Conc at which rate of elimination = rate of infusion = maintainance dose

20
Q

ED 50

A

Median effective dose- dose that produces therapeutic effect in 50 percent ppl

21
Q

Td 50

A

Dose that produces toxic effect in 50 percent ppl

Pharmacology (8 decks)

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