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General Pharmacology Flashcards

(94 cards)

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1
Q

Isoniazid MOA

A

Mycolic acid inhibitor

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2
Q

Pyrazinamide MOA

A

Mycolic acid inhibitor

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3
Q

Isoniazid and Pyrazinamide treat

A

Mycobacterial infections (TB)

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4
Q

Rafampin, Rifabutin, Rifapentin MOA

A

Inhibit bacterial RNA polymerase

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5
Q

Ethambutol MOA and use

A

Arabinosyl transferase inhibitor for mycobacterial infections

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6
Q

Dapsone MOA and use

A

Folic acid synthesis inhibitor for mycobacterial infections

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7
Q

TMP-SMX MOA and use

A

Folate synthesis inhibitors for Pneumocystic jirovecii infection

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8
Q

Chloroquine treats

A

Asexual erythrocytic malarial infections

High resistance

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9
Q

Quinine use

A

Eliminates asexual erythrocytic malarial infections

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10
Q

Mefloquine use

A

Malarial prophylaxis

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11
Q

Primaquine use

A

Hepatic P. ovale and P. vivax hepatic infections

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12
Q

Artemesinin use

A

MDR Plasmodium falciparum infections

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13
Q

Bendazole MOA

A

Prevent parasitic mitosis

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14
Q

ALbendazole and Mebendazole use

A

Ascariasis, pinworm, hookworm, and whipworm

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15
Q

Thiabendazole use

A

Strongyloides infection and cutaneous larval migrans

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16
Q

Ivermectin MOA

A

causes hyperpolarization of helminthic muscle cells

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17
Q

Ivermectin use

A

Strongyloides

Nematodes (Loa loa, river blindness)

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18
Q

Pyrantel pamoate MOA

A

Depolarizes nematode muscle cells via cholinergic nicotinic receptors

PINWORMS

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19
Q

Praziquantel MOA and use

A

Increases Ca permeability to treat tapeworm and fluke infection

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20
Q

Amphotericin B MOA

A

Binds to ergosterol to form holes in fungal cell membrane

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21
Q

Azoles MOA

A

Inhibit ergosterol synthesis

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22
Q

5-flucocytosine MOA

A

Inhibits protein and nucleic acid synthesis by acting as pyramidine analog

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23
Q

-FUNGIN (echincandin) MOA

A

Inhibit fungal cell wall synthesis via B-glucan synthesis inhibition

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24
Q

Griseofulvin treats

A

Dermatophyte infections

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25
TerbinaFINE MOA
inhibits qualine epoxidase to inhibit ergosterol synthesis
26
Nystatin MOA
Binds to ergosterol to form pores in fungal cell wall
27
Penicillins MOA
PBP binding and inhibition
28
Penicillins adverse effect
Hypersensitivity
29
Cephalosporins MOA
PBP binding and inhibition
30
Cephalosporins adverse effect
Hypersensitivity
31
Aztreonam MOA
Monobactam PBP binding
32
Carbapenems MOA
PBP binding
33
Vancomycin MOA
Prevents peptidoglycan elongation to prevent cell wall synthesis
34
Bacitracin MOA
Blocks nucleic acid incorporation into cell wall
35
Fosfomycin MOA
Prevents UDP-N-acetylmuramic acid synthesis
36
Daptomycin MOA
Bactericidal via cell wall membrane binding and depolarization
37
Aminoglycosides MOA
30S binding to block initiation complex
38
Macrolides MOA
50S P site binding
39
Aminoglycosides side effects
Nephrotoxicity | Ototoxicity
40
Tetracyclines MOA
30S A site binding
41
Tetracyclines side effects
Photosensitivity
42
Clindamycin MOA
50S binding
43
Chloramphenicol MOA
50S binding
44
Linezolid MOA
50S binding
45
Chloramphenicol side effect
Gray baby syndrome
46
Sulfazonamides MOA
PABA competiter to block folic acid synthesis
47
Trimethoprims MOA
DHFR inhibitors to block DNA synthesis
48
(FLOXACIN) Fluoroquinolones MOA
Topoisomerase II and IV blocker to prevent DNA winding and separation
49
Phenelzine class
MAOI
50
Tranylcypromine class
MAOI
51
Selegiline class
MAOI -B at low dose
52
Imipramine class
TCA
53
Desipramine class
TCA
54
Amitriptyline class
TCA
55
Fluoxetine class
SSRI
56
Sertraline class
SSRI
57
Paroxetine class
SSRI
58
Citalopram class
SSRI
59
Escitalopram class
SSRI
60
Fluvoxamine class
SSRI
61
Venlafaxine class
SNRI
62
Duloxetine class
SNRI
63
Trazodone MOA
5-HT2 receptor blocker for insomnia
64
Bupropion MOA
NE and DA reuptake blocker
65
Valproic acid use
Acute mania
66
Carbamazepine use
Acute mania
67
Barbituates MOA
potentiate GABA Cl receptors for neuronal inhibition
68
Buspirone use
Non sedating anxiolytic
69
Buspirone MOA
Partial 5-HT1A receptor agonist
70
Doxapram use
Counters post anesthetic respiratory depression
71
Doxapram MOA
Binds to carotid and medullary chemoreceptors to increase TIDAL VOLUME and RR
72
Amphetamines MOA
Increase synaptic DA, NE and inhibit DAT, SERT, NET
73
Rapid acting insulins
Lispro Aspart Glulisine
74
Long acting insulins
Detemir | Glargine
75
Metformin MOA
Decreases HEPATIC glucose output
76
Metformin side effects
Diarrhea Nausea B12 Deficiency
77
Sulfonylureas
Glimepiride Glipizide Glyburide
78
Sulfonylureas MOA
Inhibit ATP sensitive K channels to stimulate RELEASE OF INSULIN
79
Meglinitides
RepaGLINIDE | NateGLINIDE
80
Sulfonylureas and meglinitides MOA
Inhibits ATP sensitive K channels to stimulate RELEASE OF INSULIN
81
SUlfonylureas and meglinitides side effects
HYPOGLYCEMIA GI upset Weight gain
82
Glucosidase inhibitors
Acarbose | Miglitol
83
Acarbose and Miglitol MOA
GLucosidase inhibitors in brush borders to decrease GLUCOSE uptake
84
PiroGLITAZONE and RosiGLITAZONE use
Oral antidiabetic agents
85
PioGLITAZONE and RosiGLITAZONE MOA
Activate PPARy to decrease peripheral resistance May cause MI or hypoglycemia
86
-GLIPTIN suffix use
Oral antidiabetic agents
87
-GLIPTIN suffix MOA
Inhibit INCRETIN degredation via DPP inhibition
88
-GLIPTIN side effects
URI Pharyngitis PANCREATITIS
89
-GLIFLOZIN use
Oral antidiabetic agent
90
-GLIFLOZIN MOA
SGLT2 inhibitor to reduce RENAL glucose reabsorption
91
Capsaicin MOA
Depletes SUBSTANCE P
92
Capsaicin use
RA OA Neuralgia
93
Methadone use
Opioid to help treat addicts
94
MAOI and opioid adverse effect in combination
Hyperpyrexia and HTN

Pharmacology Boards (5 decks)

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