genes Flashcards
1
Q
ch 1q gains
A
-phyodes tumor (cystosarcoma)
2
Q
TP53
A
- HER+ (ER+/-) BC (li-fraumeni sund)
- ER- HER- if not have BRCA1 mutation
3
Q
e-cadherin+
A
- DCIS
- micropapillary carcinoma (but not attach to stroma!!)
4
Q
loss e-cadherin (CDH1 gene)
A
- atypical ductal or lobular hyperplasia
- LCIS
- lobular carcinoma
5
Q
Chr. 16q deletion
A
“flat epi atypia”
-atypical ductal or lobular hyperplasia
6
Q
STK11
A
BC
7
Q
BRCA1
A
- BC (usu ER-, HER-; “basal-like”)
- other epithelial cancers (prostate or pancreatic)
- ovarian CA
- medullary carcinoma (but most arent, some hypermethylated)
8
Q
HOXB13
A
-phyodes tumor (cystosarcoma)
9
Q
e-cadherin+
A
DCIS
10
Q
BRCA2
A
- BC (usu ER+ HER-high prolif; “luminal”)
- other epithelial cancers (prostate or pancreatic)
- male BC
11
Q
PTEN
A
BC
