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endo/repro2 - breast > morph > Flashcards

morph Flashcards

1
Q
  • Lacks high grade nuclei or central necrosis.

* Micropapillary pattern: Bulbous protrusions w/t fibrovascular core in complex intraductal patterns.

A

noncomedo DCIS

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2
Q

signet ring cess w intracytoplasmic mucin droplets

A

lobular carcinoma

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3
Q

fibromatosis

A

clonal proliferation of fibroblasts and myofibroblasts

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4
Q

mucin + signet ring cells

A

LCIS

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5
Q

o Ectatic dilated ducts w inspissated secretions and lipid laden Mfs.
o Rupture → periductal and interstitial inflamm. rxn w lymphocytes and plasma cells also joining the party.
o granulomas around cholesterol deposits & secretions

A

duct ectasia

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6
Q

 ~ sweat glands.

 enlarged round nuclei w prominent nucleoli and lots of eos or granular cyto

A

apocrine carcinoma

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7
Q
  • Thick BM of atrophic ducts & lobules.

* Surrounded by prominent lymphocytic infiltrate

A

Lymphocytic Mastopathy (sclerosing lymphocytic lobulitis)

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8
Q
  • clusters/linear//branching areas of calcification
  • pleomorphic high grade nuclei
  • central necrosis
A

comedo DCIS

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9
Q

neutrophils + Mfs in breast tissue

A

acute fat necrosis of breast

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10
Q

Mimics lactating breasts by forming dilated spaces filled with eosinophilic material.

A

secretory carcinoma

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11
Q
  • Lacks high grade nuclei or central necrosis.

* Cribiform pattern: Rounded spaces within ducts (cookie cutter) or solid pattern

A

noncomedo DCIS

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12
Q
  • well diff

- mucinous, papillary, cribiform or lobular patterns

A

ER(+), HER2(-), high Proliferation Invasive (infiltrating) Carcinoma

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13
Q

rounded cells not attached to adjacent cells (discohesive)

A

LCIS (bc lack e cadherin)

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14
Q

hollow balls of cells that float within intercellular fluid creating structures that mimic the appearance of true papillae

A

micropapillary carcinoma

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15
Q

 Consists exclusively of well-formed tubules.
 Cribiform pattern maybe
 Apocrine snouts
 Calcifications may be seen in the lumens.

A

tubular carcinoma

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16
Q

 Soft or rubbery and has pale gray-blue gelatin appearance.
 Borders are pushing or circumscribed.
 Cells are clustered in small islands within large mucin lakes.

A

Mucinous (colloid) Carcinoma

17
Q

Dense collagenous CT and ductal epithelail hyperplasia (no lobule formation)

A

male breast cancer

18
Q

 contain turbid, semi transluscent brown-blue fluid (blue domed cyst).
 Lined with flattened, atrophic epi or metaplastic apocrine cells.

A

cysts: nonproliferative breast change

19
Q
  • leaf-like
  • Larger lesions have bulbous protrusions d/t nodules of proliferating stroma covered by epi.
  • Higher cellularity, mitotic rate, nuclear pleomorphism, stromal overgrowth, infiltrative borders
A

phyllodes tumor (cystosarcoma)

20
Q
  • Lacks high grade nuclei or central necrosis.

* True papillae pattern: Fibrovascular core w/o myoepi cell layer.

A

noncomedo DCIS

21
Q
  • poorly diff
  • fibrotic or necrotic center
  • -lymphocytic infiltrate
  • basal keratins
A

ER(-), HER2(-) Invasive (infiltrating) Carcinoma

22
Q

cluster of lg cells w pale cytoplasm containing MPS

A

paget dis of nipple

23
Q

fat containing lesions

A

lipoma

24
Q

fibroblasts and inflamm. cells lead to giant cells, calcifiations & deposition of hemosiderin → scar tissue.

A

chronic fat necrosis of breast

25
Q

“indian file” infiltration

A

lobular carcinoma

26
Q

ill-defined, firm, grey-white nodules containing small chalky white foci

A

scar tissue from fat necrosis of the breast

27
Q

o Keratinizing squamous metaplasia of the nipple ducts.
o Ductal system is plugged by shed cells → dilation & eventually rupture of the duct.
o Keratin spills into the surrounding periductal tissue → intense chronic granulomatous response.
o Acute inflamm. may occur secondary to anaerobic bacterial infxn.

A

Squamous Metaplasia of Lactiferous Ducts

• AKA: Subaerolar abscess, Periductal mastitis, or Zuska dz.

28
Q
  • poorly diff
  • apocrine or micropapillary
  • extensive DCIS
A

HER+ Invasive (infiltrating) Carcinoma

29
Q

o Well-cicumscribed, rubbery, greyish-white nodules that bulge above the surrounding tissue and contain slit-like spaces
o In older women, the stroma typically becomes densely hyalinized and the epi atrophic.

A

fibroadenoma

30
Q

 Soft d/t minimal desmoplasia.
 well circumscribed mass.
 Solid, syncytium sheets of lg cells w lg, pleomorphic nuclei, prominent nucleoli (75% of tumor mass)
 Frequent mitotic figures.
 Lymphoplasmacytic infiltrate surrounding & within the tumor.
 Pushing (noninfiltratitve) border

A

medullary carcinoma

31
Q

true papilla: Fronds of fibrovascular tissue lined by tumor cells

A

papillary carcinoma

endo/repro2 - breast (7 decks)

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