Genes/Syndromes Flashcards Preview

Path: Neoplasia > Genes/Syndromes > Flashcards

Flashcards in Genes/Syndromes Deck (19)
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1

Xeroderma pigmentosum

DNA nucleotide excision repair, UV light, dimers

2

Multiple endocrine neoplasia-1

ret, pancreatic islet cells

3

Multiple endocrine neoplasia-2

RET; thyroid medullary, oncogene

4

Breast and ovarian cancer

BRCA1,2 DNA repair, tumor suppressor

5

Retinoblastoma

Rb, binds to E2F, tumor suppressor G1-S phase

6

Familial adenomatous polyposis

APC, colorectal caner

7

HNPCC/Lynch syndrome

Colorectal cancer, DNA repair

8

Li-Fraumeni

TP53, many cancers due to P53 mutation, G1-S phase

9

Ataxia-telangiectasia

ATM, lymphoma and leukemia

10

CML

abl, oncogene, tyrosine kinase, philadelphia 9:22 translocation

11

Burkitt's lymphoma

c-myc, EBV, Africa, oncogene, 8:14 translocation

12

Follicular lymphoma

bcl-2, oncogene, anti-apoptosis

13

Breast, ovarian, gastric cancers

erb-B2, oncogene (HER2/neu) receptor tyrosine kinase

14

Carcinomas, melanomas, lymphomas

Ras GTPase, oncogene

15

Lung tumors

L-myc, oncogene

16

Neuroblastoma

n-myc, oncogene

17

Cowden syndrome

PTEN, tumor suppressor, hamartomas

18

Melanoma

CDK4

19

Mantle-cell lymphoma

CCND1 t(11;14) with IgH