Genetic Imprinting Flashcards
1
Q
epigenetic
A
mitotically and meiotically heritable variations in gene expression (not caused by DNA sequence change.)
2
Q
Genetic imprinting
A
sex dependent epigenetic modulation. inherited transcriptional active or inactive instruction paternally or maternally.
3
Q
DNA methylation causes
A
- compacted chromatin
- transcriptional repression
4
Q
Info about DNA methlylation
establishment, maintenance, erasure and resetting
A
- establishes in the mark in gemetes
- maintained in somatic cells after fertilization
- erasure and resetting during gemetogenesis, to pass down appropriate sex specific imprint to progeny
5
Q
Maintenance Methyltransferase
A
propagate methyl marks in somatic cells as DNA replication happens.
6
Q
Consequence of skipping erasure
A
high frequency of embryos with no active copies or two active copies of imprinted genes.
7
Q
Prader-Willi Syndrome cause
A
Deletion of paternal Chromosome 15, del (15q11-q13)
