Genetics and obesity Flashcards
1
Q
how could genetics effect obesity?
A
appetite
fat oxidation
physical activity
2
Q
what have twins studies shown in relation to genetics and obesity?
A
stunkard et al 1986
Mono and Dizygotic twins
self reported Body Mass at 20
25 year follow up
close correlation at baseline and follow up
correlation more prominent in monozygotic twins
3
Q
what are mongenic syndromes?
A
Defect in a single gene resulting in obesity ❖ Severe forms of obesity ❖ Very rare ❖ Big advances ❖ All effect satiety ❖ Therapies ❖ Mental abnormalities or not
4
Q
what is congential leptin therapy?
A
Leptin involved in long term energy balance ❖ Leads to reduction in hunger ❖ Ob/Ob mouse ❖ Can't produce leptin ❖ Very hungry ❖ Becomes obese ❖ Very very rare
5
Q
what is leptin receptor deficiency?
A
Leptin has to bind to receptor ❖ Defect in gene encoding receptor ❖ No effect of leptin ❖ Similar symptoms to leptin deficiency ❖ Very rare
6
Q
what is nutrigenomics?
A
the effect of nutrient intake on gene expression
7
Q
what is nurtigenetics?
A
the effect of genetic variation on response
