Nanomedicine

Question 1

What is nanotechnology?

Answer 1

The application of scientific knowledge to manipulate
and control matter in the nanoscale in order to make use
of size- and structure-dependent properties and
phenomena distinct from those associated with
individual atoms or molecules or with bulk materials”.
an emerging technology

Question 2

what is a nanomaterial?

Answer 2

material with any external dimension in the nanoscale or having
internal structure or surface structure in the nanoscale.
 Nanoscale: size range from approximately 1 nm to 100 nm

Question 3

what is a nano object?

Answer 3

material with one, two or three external dimensions in the nanoscale

Question 4

what is a nanoparticle?

Answer 4

nano-object with all three external dimensions in the nanoscale.

Question 5

what is a quantum dot?

Answer 5

a crystalline nanoparticle that exhibits size-dependent properties due
to quantum confinement effects on the electronic states.

Question 6

what are the properties of nanoparticles?

Answer 6

due to their size:

• high SA:V ratio therefore highly reactive
• can penetrate cells

Question 7

what are some of the charachteristics of nanoparticles?

Answer 7

Size
 Surface charge
 Surface chemistry
 Shape
 Porosity
 Agglomeration state

Question 8

What technique is used to determine the charachteristics of nanoparticles?

Answer 8

Photon Correlation Spectroscopy (PCS) measurements
also known as Dynamic Light Scattering
measurements are carried out by using a malvern zetasizer nano ZS

usually a laser is shot through a polarizer and into a sample

Question 9

What is nanomedicine?

Answer 9

• the medical application of nanotechnology to achieve breakthroughs in healthcare
• this is applied at a molecular level
• exploitation of nanoparticles unique properties (eg. composition/ ability to tag surface with targeting molecules)

Question 10

Give 3 examples of medical uses of nanomedicine

Answer 10

imaging diagnostics (eg radiology)
Targeted drug delivery
Cancer therapy (eg. injected into tumour to produce heat and destroy local cancer cells)

Question 11

What are the 3 modes of exposure for nanoparticles in vascuular function?

Answer 11

intra-arterial administration
translocation through inhalation/ ingestion
intravenous