GH

Question 1

Clomifene

Answer 1

Estrogen receptor agonist/antagonist

Question 2

Gn RH stimulates release of

Answer 2

LH and FSH

Question 3

Growth hormone receptor agonist

Answer 3

Somatropin

Question 4

Somatostatin receptor agonist

Answer 4

Octreotide

Question 5

Growth hormone receptor antagonist

Answer 5

Pegvisomant

Question 6

Dopamine receptor agonists

Answer 6

Bromocrptine and cabergoline

Question 7

Acromegaly due to

Answer 7

Long lasting growth or somatotropic hormone hypersecretion with 2 dairy growth for IGF 1

Question 8

Hyperprolactinemia cause

Answer 8

Galactorrhoea,menstrual cycle disturbance (oligomenorrhea or amenorrhea) , infertility,benign tumors

Question 9

Turner syndrome

Answer 9

Chromosome changes,in women,affect height and sexual development

Question 10

IGF 1 promote anabolic processes like

Answer 10

Protein synthesis, development of bone growth plate formation,cell proliferation

Question 11

Somatropin use

Answer 11

Replacement therapy in case of diagnosed growth hormone deficiency like turner syndrome

Question 12

Prolonged somatropin overdose cause

Answer 12

Gigantism and acromegaly

Question 13

STH is antagonist to insulin as it IGF 1 works similar to

Answer 13

Insulin

Question 14

Octreotide action

Answer 14

Inhibits STH secretion and suppress TSH secretion,so it reduce several gastroenteropancreatic peptide secretion and may also cause hypothyroidism

Question 15

Hypothyroidism may manifest as

Answer 15

Bradycardia, cardiac arrythmia

Question 16

Octreotide is

Answer 16

Anti secretary

Question 17

Use of octreotide

Answer 17

Acromegaly, gastroenteropancreatic carcinoid tumours, treatment of TSH secretary pituitary adenomas

Question 18

SE of octreotide

Answer 18

Hypothyroidism

Question 19

Pegvisomant action

Answer 19

Only decrease in IGF 1 secreti,but STH secretion unaffected

Question 20

Use of pegvisomant

Answer 20

Acromegaly

Question 21

D 2 receptor agonist action

Answer 21

Delays STH secretion,inhibits prolactin secretion

Question 22

Use of D2 receptor agonist

Answer 22

Acromegaly, hyperprolactinemia,Malignant neuroleptic malignant syndrome (bromocrptine)

Question 23

SE of D2 receptor agonists

Answer 23

Impulse control disorders -pathological gambling, increase in sex drive,hypersexuality,compulsive spending of money and shopping

Question 24

GnRH receptor agonists

Answer 24

Goserelin,Triptorelin

Question 25

GnRH receptor antagonist

Answer 25

Degarelix

Question 26

Use of GnRH agonist

Answer 26

Prostate cancer,breast cancer, endometriosis

Question 27

Degarelix,GnRH antagonist action

Answer 27

Decrease LH and FSH, Testosterone

Question 28

Degarelix use

Answer 28

Prostate cancer

Question 29

Oxytocin receptor and vasopressin receptor agonist

Answer 29

Oxytocin and desmoxytocin

Question 30

Vasopressin receptor agonist

Answer 30

Desmopressin

Question 31

Oxytocin and desmoxytocin action

Answer 31

Rhythmic contraction of uterus,lactogenic effect

Question 32

Oxytocin and desmoxytocin use

Answer 32

Stimulation of labour, postpartum hemorrhage,lactation stimulation

Question 33

SE of oxytocin and desmoxytocin

Answer 33

Water intoxication risk

Question 34

Diabetes insipidus is usually due to reduced ADH secretion

Answer 34

Central diabetes insipidus

Question 35

There will be polyuria due to

Answer 35

Diabetes insipidus

Question 36

Lithium carbonate reduce expression of

Answer 36

Aquaporin gene(AQP2)

Question 37

Desmopressin use

Answer 37

Diabetic insipidus,night enuresis

Question 38

SE of desmopressin

Answer 38

Hypertension and hyponatremia

Question 39

Demopressin action(V2 receptor agonists)

Answer 39

Water reabsorption from distal renal and collecting duct,affect blood clotting system