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GH, Prolactin And Gonadotropin > New > Flashcards

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1
Q

Somatostatin analogue

A

Octreotide,lanreotide

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2
Q

Dopamine receptor antagonist

A

Cabergoline, bromocrptine,quinagolide

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3
Q

Mecasermin

A

Recombinant IGF1 given before or after meal due to risk of hypoglycemia

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4
Q

Clomifene

A

Estrogen receptor agonist/antagonist

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5
Q

GnRH analogue

A

Gonadorelin , goserelin,buserelin

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6
Q

GnRH antagonists

A

Cetrorelix,Ganirelix, Degarelix

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7
Q

Follitropin alpha

A

FSH recombinant

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8
Q

Lutropin alpha

A

LH recombination

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9
Q

HMG(Human Menopausal Gonadotropin)

A

Contain both LH and FSH

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10
Q

HCG (Human chorionic Gonadotropin

A

Mimic LH

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11
Q

Pulsatile administration of GnRH and analogues increase

A

Secretion of LH and FSH

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12
Q

Cont administration of GnRH analogue cause

A

Downregulation of GnRH receptor

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13
Q

Somatropin

A

Synthetic growth hormone

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14
Q

Octreotide

A

Analogue of somatostatin

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15
Q

Somatostatin is also called

A

SST/GHRIH(Growth hormone release inhibitory hormone)

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16
Q

GH receptor antagonist

A

Pegvisomant

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17
Q

GH receptor agonist

A

Somatropin

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18
Q

Acromegaly

A

Somatropin hypersecretion with secondary increased secretion of somatomedin or IGF1, mostly due to pituatry adenoma.Primary is surgical treatment

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19
Q

Hyperprolactinemia causes

A

Galactorrhoea, menstrual cycle disturbance, infertility

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20
Q

Hyperprolactinemia etiology

A

Benign tumor (prolactinoma,or medications such as antipsychotics

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21
Q

Somatotropin (STH )analogue

A

Somatropin

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22
Q

Somatropin action

A

Activate IGF1 secretion in liver,which promotes protein synthesis,bone development growth plate dev ,so anabolic action

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23
Q

Use of somatropin

A

Replacement therapy in case of diagnosed growth hormone deficiency like turner syndrome

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24
Q

SE somatropin

A

Overdose cause a acromegaly and gigantism, prohibited doping drug

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25
Direct effect of GH which is antagonistic to insulin action
Increase lipolysis and blood sugar
26
STH analogue should be used in caution for
Diabetic patient
27
IGF1 has similar effect of
Insulin
28
Octreotide action
Inhibit somatotropin (STH) secretion, reduce reduce IGF1 secretion reduce gastroenteropancreatic peptide like insulin and glucagon (caution for DM patients)Suppress TSH secretion-hypothyroidism:manifest as bradycardia, cardiac arrythmia
29
Octreotide (anti secretary action) use
Acromegaly,gastroenteropancreatic carcinoid tumours (insulinoma,gastrinoma), treatment of TSH secreting pituatry adenomas
30
SE of octreotide
Hypothyroidism
31
STH receptor /GH receptor antagonist
Pegvisomant
32
Pegvisomant is given
Subcutaneously
33
Pegvisomant action
Decrease IGF1 secretion,STH 1 secretion is unaffected (anti secretary action)
34
Pegvisomant use/indication
Acromegaly
35
Pegylation use(Polyethylene glycol added)
Longer duration of action and reduced risk of antibody formation
36
D2 receptor agonist action
Delay STH secretion and inhibit prolactin secretion (anti secretory)
37
Use of D2 receptor agonist
Acromegaly , Neuroleptic malignant syndrome (bromocrptine) and hyperprolactinemia
38
SE of D2 receptor agonists
Impulse control disorders like pathological gambling,increased sex drive, hypersexuality, compulsive spending of money
39
Acromegaly treatment options
Octreotide (somatostatin analogue), pegvisomant (STH /GH receptor antagonist), Bromocrptine, cabergoline (D2 receptor agonist)
40
Hypothyroidism is SE of
Octreotide (somatostatin analogue)
41
Prostate cancer treatment
Radical prostate ectomy, radiation therapy, testesterone lowering therapy, surgical castration(orchiectomy), medical castration or hormonal therapy, GnRH agonists and antagonist, Androgen receptor antagonist (chemotherapy,if hormonal therapy doesn't work)
42
Breast cancer treatment
Radical mastectomy, hormonal therapy, chemotherapy
43
Endometriosis is
Implantation of endometrium(glands and stroma) outside the uterus ,which cause chronic pelvic pain
44
Treatment for endometriosis
Hormonal therapy with progestins, GnRH agonists and surgical therapy
45
GnRH receptor agonists (Goserelin Triptorelin) action
Inhibit LH and FSH secretion,secondary inhibition of ovarian and testicular secretory fn:after initial rise in LH and FSH downregulation starts till castration effect.(Antiproliferative)
46
GnRH receptor agonists( Goserelin , Triptorelin)use
Prostate cancer,breast cancer, endometriosis
47
Degarelix (selective GnRH antagonist) action
Dose dependent suppression of LH and FSH and secondary testesterone release (Antiproliferative), immediate action
48
Use of degarelix
Prostate cancer
49
Oxytocin receptor and vasopressin receptor agonist
Oxytocin,demoxytocin
50
Vasopressin receptor agonist
Desmopressin
51
Oxytocin and desmoxytocin action
In small doses cause rhythmic contraction of uterus,on high dose spastic contractions, : so uterotonic effects + stimulate contraction of myoepithelial cells of uterus
52
Use of oxytocin and desmoxytocin
Stimulation of labor, postpartum hemorrhage, lactation stimulation (only desmoxytocin)
53
Overdose of oxytocin and desmoxytocin and combined with large IV fluids cause
Water intoxication risk
54
Diabetes insipidus symptoms
Polyuria (increased urine output (upto 20l/day, decreased secretion of ADH caused by brain injury,tumor, infection, autoimmune disease, medication like lithium carbonate
55
Lithium carbonate reduce -what type of aquaporin
AQP2 gene expression -reduced water reabsorption
56
Desmopressin
V2 receptor agonist
57
Desmopressin action
Stimulate expression of AQP2 and increase reabsorption of water in distal tubules and collecting duct (anti-diuretic),; affect blood clotting system
58
Use of desmopressin
Diabetes insipidus treatment (centre),night enuresis
59
SE of desmopressin
Hypertension and hyponatremia
60
Desmopressin on binding to v1 A receptor in blood vessels cause
Smooth muscles vasoconstriction
61
Prostate cancer treatment possibilities
GnRH receptor agonists (Goserelin Triptorelin), GnRH receptor antagonist (degarelix)

GH, Prolactin And Gonadotropin (2 decks)

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