Flashcards in GI 1 Deck (96)
What is the fancy word for "Canker Sore?"
Are aphthous ulcers found or keratinized, or non-keratinized epithelium?
What four things can trigger aphthous ulcers?
What two types of inflammatory cells are found in an aphthous ulcer? Name two other characteristics.
Monocytes and polys. The lesions have a red (erythematous) rim and gray-white exudate.
Name the condition: Shallow ulcer of the oral cavity covered by fibrinopurulent exudate with underlying infiltrate composed of monocytes and polymorphs.
Are aphthous ulcers usually self-limiting and heal without scarring?
Which viruses causes herpetic stomatitis?
HSV1 or HSV2
____% of the population becomes infected by the HSV1 virus by midlife.
Primary infection with herpes simplex virus is ___________ and the virus persists in a _________ state within ganglia around the mouth.
asymptomatic, persists in a dormant state
Are oral infection rates of HSV2 rising?
Name eight things that can activate the herpex simplex virus.
3. Cold exposure
4. Respiratory tract infection
Describe herpes lesions (size, what they're filled with, where they occur).
Small (<5mm dia), single or multiple, filled with clear exudate on lips and around nasal orifices.
Do herpes lesions often rupture?
Name three cellular changes seen in a herpes lesion.
1. Ballooning degeneration of infected cells.
2. Intranuclear acidophilic viral inclusions.
3. Multinucleated polykaryons (fusion of cells).
What is the Tzanck test? Name one infection that yields a positive Tzanck test.
Looking at vesicle fluid (from a blister) under the microscope and seeing acidophilic viral inclusions and polykaryons. Typical of Herpes infection.
Herpetic gingivostomatitis and lymphadenopathy may develop in herpes-infected patients who are __________.
Which infectious agent causes pseudomembranous candidiasis/thrush? Where is this agent found?
Caused by the yeast Candida albicans which is part of the normal oral biota.
Name six conditions that can put a person at risk for oral candidiasis/thrush.
3. Antibiotic or steroid therapy.
4. HIV infection
5. Metastatic cancer
6. Infants can get it
Describe the gross appearance of a thrush lesion.
White, curd-like circumscribed plaque in the oral cavity.
Oral candidiasis may spread to the _________ and is life-threatening if it continues to spread.
Why is candidiasis referred to as PSEUDOmembranous?
The pseudomembrane can be scraped off.
What is found in the pseudomembrane of a thrush plaque?
Fungal organisms in the fibrous pus (fibrinosupperative exudate) which are superficially attached to the underlying granular erythematous inflammatory mucosa.
What is the WHO definition of leukoplakia?
A white patch or plaque that CAN'T BE SCRAPED OFF and can't be classified as any other disease.
Is leukoplakia cancer?
No, its a preneoplastic lesion.
Which habits predispose people to leukoplakia?
Use of tobacco, especially pipe smoking and chewing tobacco.
What is buccal mucosa?
The inside lining of the cheeks
Do aphthous ulcers often occur in the same exact locations repeatedly?
Can leukoplakia vary from simple hyperkeratosis without underlying dysplasia to severe dysplasia bordering on carcinoma in situ?
What is the frequency of malignant transformation from leukoplakia to squamous cell carcinoma?
5 to 25%