GI Flashcards

(58 cards)

1
Q

define autotrophs

A

Autotrophs are able to make their own food- All plants and some prokaryotes are autotrophic- photosynthesis

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2
Q

define heterotrophs and the 3 types

A

“Heterotrophs obtain organic (carbon-based) food which was originally synthesised by plants (Animals, Fungi, Some protists and prokaryotes)

-Holozoic nutrition:
- Solid or liquid food/organic material is taken in, broken down and absorbed
- Most animals
- Complex food taken into specialist digestive system.

-Saprotrophic nutrition
- live and feed off dead or decayed organic matter
- secrete enzymes which digest the food then absorb the soluble products- fungi

-Parasitic nutrition:
- Parasites
- Live on or in a host organism from which they obtain their food”

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3
Q

what are the 6 processes of digestion with brief descriptions

A

Ingestion – taking food into GI

Propulsion – moves food through alimentary canal
- swallowing,
- peristalsis

Mechanical breakdown
- mastication,
- churning,
- segmentation
- Increases surface area

Chemical digestion
- Enzyme secreted into lumen

Absorption
- Uptake of digested products

Egestion:
- Elimination of indigestible material from the body”

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4
Q

what are the sources and function of protein, carbs and lipids in the diet

A

“Proteins –
source: Milk, eggs, meat, fish – complete Legumes, nuts, cereals – incomplete (low in one or more essential amino acids)
Function: Structural role- skin, hair, teeth, bone, muscle.
metabolic roles, enzymes, hormones, transport proteins

Lipids -
sources: Triglycerides animal products (saturated) Unsaturated in seeds , nuts olive oil, Cholesterol – egg, yolk, meats, dairy. ,
Function: Fatty adipose tissue (energy store), Insulation, Protection, phospholipids – cell membranes, Cholesterols – cell membranes, hormones

Carbohydrates
Sources: Mainly plants from plants, Simple sugars – from fruits, sugar cane, sugar beet, honey and milk, Complex carb – grains and veges
Function: energy source - glucose
Red blood cells and neurones.
The glycocarlyx”

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5
Q

name the vitamins needed, their sources and function

A

“A- Retinol- Liver, milk, egg yolk, carotene- Formation of rhodopsin
B1- Thiamine- Cereal, brown rice, nuts and beans- TPP – coenzyme
B2- Riboflavin- Milk, eggs, yeast, liver, cereal- FAD – coenzyme in respiration
B3- Niacin- Nuts, meat and grain- Co-enzymes NAD, NADP
B5- Pantothenic acid- Most foods- Component of co-enzyme A
Vitamin C- Ascorbic acid Fresh fruit and vegetables- Electron carrier, collagen formation, utilisation of iron, stimulates immune system
D- Cholecalciferol- Synthesized in the skin, dairy products, oily fish, egg yolk- Calcium metabolism
E- Tocopherol- Vegetable oils, nuts, green leafy vegetables, and fortified cereals- Antioxidant, free radical scavenger, membrane integrity
K- Phylloquinone menaquinone- Green leafy vegetables- Blood clotting
Osteocalcin synthesis”

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6
Q

factors affecting energy requirements in animals

A

gender
- females need fewer calories than male animals because males generally have a higher metabolic rate
- Studies shows that neutered animals are twice as likely to become obese compared to intact dogs.

growing animals:
requires higher concentrations of protein (amino acids), calcium, phosphates, and energy in the diet to support basic physiological processes in addition to bone, connective tissue, muscle, and coat formation

pregnancy and lactation:
rely on forage and are only given concentrates during the last stages of pregnancy and early lactation.

Dairy cows need high levels of ME to sustain milk yields and so are fed concentrates to supplement forage

Small animals also have increased energy demands during late pregnancy and lactation, although cats show an increased intake from conception

Water is essential for all animals during lactation – thing that is often forgotten

Folic acid is especially important in the early stages as it’s crucial for development of the neural tube.

working animals:
Racehorses require a diet that is high in energy to fuel the levels of performance- require water

  • supply of fast- and slow-release energy
  • diets high in fat, protein, fibre and starch are appropriate for high-performance racehorses and they can obtain most of these nutritional elements from a combination of forage”
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7
Q

what are the 4 layers of the GIT and describe

A

“The mucosa
- Epithelial layer, protective, cells have a short lifespan (2/3 days), secretions, absorption
- Connective tissue layer, blood vessels, nerves, lymph vessels
- Muscularis mucosae, thin smooth muscle layer

The Submucosa
- Connective tissue, blood vessels and nerves

Musculariz
- 2 layers of smooth muscle, inner circular and outer longitudinal
- Myenteric plexus: a network of neurons between the 2 layers

Serosa
- A thin layer of connective tissue
- Covered by the peritoneum (epithelial cells)”

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8
Q

describe the oesophagus

A

”- Runs from pharynx to stomach. Role is to convey food to the stomach
- Cervical, thoracic and abdominal sections
- Muscularis – striated initially and then becomes smooth. Muscles needed for PERISTALSIS
- Mucosa – Stratified squamous epithelia for extra protection
- Sphincters at upper opening of oesophagus and at junction with stomach
- In many species, it enters stomach at sharp angle, aids function of lower sphincter and reduces vomiting (eg horses).”

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9
Q

describe peristalsis and the muscles involved

A

”- The process by which food is moved along the oesophagus to the stomach
- During peristalsis, the circular and longitudinal muscles in the oesophagus contract and relax in a wave-like pattern to move food through the digestive tract:
- Circular muscles: These muscles squeeze and expand in a coordinated way to push food through the oesophagus.
- Longitudinal muscles: These muscles shorten the oesophagus and propel food forward”

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10
Q

describe the stomach and the types

A

”- Chemical and mechanical digestion (to produce chyme)
- Stores food and to transfer stomach content to SI at a rate to ensure maximum digestive efficiency. (eg. Carnivores)
- Variation between species
- Monogastric
- Ruminants”

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11
Q

describe the mono gastric stomach

A

”- Located behind diaphragm
- Sphincter prevents reflux
- 4 regions
- Cardia, small except in the pig where food is stored
- Fundus, stores food
- Corpus, mixing with gastric juice
- Pylorus, mixing, pyloric sphincter
- gastric glands on inner lining of stomach”

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12
Q

whats the role of gastric glands

A

”- Mucus production for protection from digestive enzymes/acid
- Gastric juice is secreted by gastric glands
- Gastric juice contains
- HCl from parietal cells
- pepsin from chief cells
- contain endocrine cells, -produce gastrin, a hormone that stimulates the stomach to release acid”

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13
Q

describe the role of pepsin and HCL

A

”- Pepsin is secreted from chief cells as the inactive enzyme precursor pepsinogen
- This prevents autodigestion
- Activated by HCl and pepsin itself in the lumen of the stomach
- Pepsin breaks down proteins into peptides and amino acids. It works with other enzymes, such as trypsin and chymotrypsin, to digest food

  • HCL Secreted from parietal cells in the gastric gland
  • Activates pepsinogen
  • Provides optimum pH for pepsin activity
  • causes pepsinogen to be cleaved into the active enzyme pepsin”
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14
Q

what are the 3 ways that gastric secretion is controlled

A

“1. Reflex due to sight and smell of food- The nerve impulses affect the epithelial cells directly and cause a release of gastrin
2. Expansion of the stomach by the presence of food causes smooth muscle to contract. Secretion of gastrin into the bloodstream from special cells in the pyloric region of the stomach. The hormone stimulates the secretion of pepsin and HCl. It also stimulates muscular movement of the stomach
3. Control by peptides
- Peptide production
- G cell secrete more gastrin
- Parietal cells increases HCl production”

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15
Q

what are the 4 stoamchs of ruminants and their function

A

The Rumen: The rumen stores and ferments food. Salivary enzymes aid digestion, while muscular contractions churn the contents. It houses bacteria that produce cellulase, breaking down cellulose into beta-glucose, which is further fermented into volatile fatty acids (ethanoic, propionic, and butyric acids). These acids are absorbed through the rumen wall.

Reticulum: balls of cud formed and then regurgitated

The Omasum: Once food is liquid enough, it enters the omasum, a chamber with tissue folds that absorb water and concentrate the contents.

The Abomasum: The abomasum, or “true stomach,” produces hydrochloric acid and enzymes like pepsin, breaking down food before it enters the intestines.”

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16
Q

describe the tongue and its function in the oral cavity

A

”- highly muscular organ
- surface covered in papillae,
- function of tongue- Prehension, Forming bolas, Pushing bolas back to oropharynx, taste, Grooming, Speech articulation
- function varies between species (taste buds, grooming, manipulate food)”

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17
Q

describe the role of salvilary glands in digestion

A

Salivary Glands:

Chemical digestion:
- Liquid – mixing food / formation of bolas
- Digestion
- Enzymes
- α-amylase - Amylase starts the digestion of starch (mostly)
- lysozyme - Lysozyme acts to cause lysis in bacteria.”

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18
Q

describe mastications role in digestion

A

“chewing- mechanical digestion:

  • Involves the actions of jaw, teeth, tongue and cheeks

Muscles of mastication – all of these raise the jaw”

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19
Q

describe how the size of the temporalis and masseter differ in different species

A

”- Temporalis is larger in carnivores
- Carnivores and omnivores have mainly a vertical action for a cutting effect.
- Carnivores able to open mouth wide
- the jaw joint is on the smae plane as the teeth so tighter connection

  • Masseter is larger in herbivores
    • Herbivores also move jaw laterally which helps to grind food”
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20
Q

what is the function of cementum

A

the calcified or mineralized tissue layer covering the root of the tooth which sits inside the gum socket

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21
Q

what is the function of dentine

A

hard dense bony tissue forming the bulk of a tooth, beneath the enamel

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22
Q

what is the function of enamel

A

Tooth enamel is the hard, shiny, white outer layer of your teeth that covers the underlying tissues. The hardest substance in the body, stronger than bone – and is made up almost entirely of minerals.

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23
Q

what is the function of tooth roots and the pulp cavity

A

“Tooth Roots: Attach to the alveolar bone (mandible) via the periodontal ligament
Pulp Cavity: The area in between the tooth root that contains blood vessels and nerve endings”

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24
Q

what are the muscles involved in mastication nd where are they.

A

”- Temporalis: Top of head (O) → Coronoid pr of mandible
- Masseter: Zygomatic arch (O) → Ramus of mandible
- Pterygoid: sphenoid bone (O) → condylar pr of mandible”

25
what are the 3 sections of the small intestine and describe them
"- the duodenum - the jejunum - the ileum. - The duodenum is the shortest pwhat are the 3 sections of the small intestine and describe themart of the small intestine and the least mobile portion. - Ducts from the pancreas and gall bladder enter the duodenum. - The distinction between jejunum and ileum is arbitrary but the ileum is slightly shorter and more muscular. - The jejunum and ileum are the greatly coiled part of the small intestine"
26
describe the types of contractions in the small intestine
"- Segmentation contractions - Rhythmical mixing contractions - Contraction of circular muscles - Chops, **mixes** & rolls the chyme - Peristaltic contractions - Weaker - **Moves**/propels the contents slowly along the small intestine"
27
how does digestion happen in the small intestine
"facilitated by enzymes secreted by: - Pancreas - Epithelial lining of duodenum Also: - Brunner’s glands secrete HCO3- nuetralises acid in chyme from stomach to ph6 - Pancreatic juice- contains bicarbonate + digestive enzymes - Bile is produced in the liver but stored and concentrated in the gall bladder until needed."
28
what are the roles of endo and exopeptidase
"**Endopeptidases** - break the peptide links in the interior of the molecule - e.g. pepsin (secreted by the stomach and acts within the stomach) and trypsin (secreted by pancreas – acts in the small intestine) **Exopeptidases** - break off terminal amino acids. - e.g. carboxypeptidases (pancreas) - e.g. aminopeptidases (epithelial cells)"
29
whats the role of trypsinogen in digestion
Trypsinogen us scereted by pancreas in an inactive form- trypsinogen- when it reaches where it needs to be it becomes trypsin via enzyme enterokinase where its used in endopeptidase. Then its converted to chymoytrypsin- involved in the activation of exopeptidases
30
whats the role of the ileum
"digests - Vitamin B12 - Bile salts - Nutrients not absorbed by duodenum and jejunum"
31
describe the caecum
"Caecum: Located at the junction of the small and large intestine - Ileo-caecal junction - receives material from the ileum - absorbs some of the fluid and salts - mixes the contents with mucus"
32
whats the role of the large intestine and how does it do this
"Functions: - Recovery of water - Storage of waste - Microbial digestion for herbivores (caecum) Faeces moves along the colon by peristalsis, water is reabsorbed and they become more solid. The movement is relatively slow and it can take up to 24 hours for material to travel the length of the organ"
33
describe the hormone Cholecystokinin (CCK)- when is it released, where, what does it do
"When: When amino acid and Fatty acids reach the duodenum where: Duodenal epithelial cells what: Stimulates the release of digestive secretions from the pancreas and gallbladder and slows gastric emptying – aids absorption"
34
describe the hormone Secretin- when is it released, where, what does it do
"When: Acidic conditions where: Duodenal epithelial cells what: Stimulates the pancreas to release sodium bicarbonate which neutralises acidic chyme and reduces gastric acid secretion"
35
describe the hormone Gastrin- when is it released, where, what does it do
"when: many stimuli including stomach distension and vagal nerve stimulation Where: Stomach what: Stimulates the production of gastric juices (HCl and pepsinogen) and increases gastric motility"
36
describe the hormone Enterogasterone- when is it released, where, what does it do
"when: When fatty acids or excess acids enter duodenum where: Duodenal epithelial cells what: Inhibits peristalsis and acid secretion by the stomach – aids absorption and slows progress of chyme through the intestines"
37
describe the 4 ruminant stomachs
"- Rumen**-** - Largest of the 4 compartments – almost fills entire **left** side of abdominal cavity - Huge fermentation chamber - Contains many microorganisms (bacteria, protozoa, fungi) - These supply enzymes to break down fibre etc in the food - Reticulum- - 2nd chamber - Honeycomb structure - Food freely passes between here and the rumen - Lies against the diaphram (and near to heart) - Any swallowed foreign object (wire, nails etc) tend to lodge in the reticulum - Omasum - Muscular spherical organ - Located to the right of the rumen and reticulum - Internal structure has broad longitudinal folds like leaves of a book - Involved in the **grinding** and **squeezing** of digesta and also **absorption** of water and VFAs - Abomasum - The ruminant **true or glandular** stomach - Located on the right side of the rumen - Very similar to the stomach of non-ruminants - Secretes acids and enzymes - Prepares food for further chemical digestion and absorption along the small intestine."
38
describe the digestive system of hindgut fermenters and some problems associated with them
"- Horses, rabbits, rhinos, rodents - Relatively simple stomach but larger caecum and colon where microbes are found - Considerable fermentation occurs problems: - horses - Caecum projects from side of gut - Small intestine empties directly into the caecum - Reverse peristaltic movements allows food to pass from caecum back into small intestine - rabbit - Behaviour known as **caecotrophy** - Ingestion of soft faeces (caecotrophs) originatingfrom the caecum - Caecotrophs usually produced when animal is at rest - Contain bacteria, yeasts, fermentation products (source of nutrients esp. protein)"
39
describe the size of Large intestine based on diet an stomach
"- Carnivores: –little microbial fermentation, –small LI - Pigs and ruminants: – intermediate sized coiled LI - Rodents and horses: –large LI for microbial fermentation"
40
describe the avian digestive system
"- **Beak** replaces lips and cheeks (no teeth) - **Crop** –Storage of food, –some digestion - **Proventriculus** –Glandular stomach –acid secretion - **Gizzard** –Muscular organ (grinds food) - **Two** **caeca** (absorption, some fermentation) - **Cloaca** –Faeces and urine excreted together"
41
where is the pancreas found
small, lies below stomach
42
endocrine and exocrine function of pancreas
"Endocrine function - Produces hormones: insulin and glucagon - Produced in α and β cells in the islets of Langerhans Exocrine function - Produces digestive enzymes secreted into the pancreatic duct - Produced in acini – groups of epithelial cells which secrete pancreatic juice into a lumen"
43
whats the function of liver
"- production of cholectserol/bile - synthesis of clotting factors - protein/lipid/carbohydrate metabolism - detoxification - stoarge of vitamins/cholesterol"
44
structure of liver
"- Located behind the diaphragm - 2-4 main lobes - Gall bladder not present in the horse - recieves both arterial and venous blood"
45
Describe the production, and makeup of bile.
"Bile Production: - Most cholesterol produced in the liver is used to make bile - Synthesised in hepatocytes - Secreted into channels between hepatocytes…bile canaliculi - Drains into bile duct where it may be secreted into the intestine or stored in the gall bladder first Made up of: water, bile salts, cholesterol, bilirubin, bicarbonate ions. recirculation"
46
whats the role of the liver in carb metabolism
"- Liver metabolises carbohydrates in response to insulin, glucagon and adrenaline (glycogenesis& glycogenolysis) - Liver stores glycogen - insulin turns glucose into glycogen and glucagon turns glycogen into glucose"
47
whats the role of the liver in the production of glucose from amino acids
"Gluconeogenesis- - Occurs when blood glucose concentration falls. In response to glucagon when glycogen stores decline e.g. when fasting - Making additional **glucose** from **non-carbohydrate sources** - mainly amino acids, lactate and glycerol - Pyruvate is formed from their breakdown - Pyruvate can then be used to generate glucose - Many of the reactions are the reverse steps of glycolysis - Inhibited by insulin"
48
what is transamination
"- amine group removed and added to another amino acid - the conversion of one amino acid to another - Non-essential amino acids can be synthesized by transamination to make up for deficiencies in the diet"
49
what is deamination
amine group removed → organic keto acid (and ammonia)
50
describe urea formation
"- Ammonia is converted to urea in the ornithine cycle in the hepatocytes - Urea is then transported to the kidneys in the blood where it is excreted."
51
describe the roles of fibrinogen, globulins and albumin
"- many globular proteins are synthesised in the liver - Plasma proteins help to transport other substances in the blood e.g. thyroxine - Fibrinogens are important proteins in coagulation of blood - Albumin, prevents too much water loss into the tissue fluid, it helps regulate osmotic pressure of blood"
52
whats the role of the liver in detoxification
"- Occurs mainly in the SER of the hepatocytes - Toxins are either converted into a harmless product or excreted in the bile Eg ethanol C2H5OH - ethanol -> ethanal -> acetate, alcohol dehydrogenase"
53
what are the causes, effects and treatments of liver disease in domestic species.
"Cause: congenital, hepatotoxins, infection, inflammation, obesity, Clinical signs: - Nausea, diarrhoea, Weight loss, Neurological signs due to build up of toxic substances eg urea, Jaundice, build up of bilirubin Treatment: The goals of treating liver disease are to eliminate harmful toxins promote healing and regeneration of liver tissue, prevent or control complications of liver dysfunction and treat the underlying cause where possible"
54
when is an animal classed as obese
"- 15-20% overweight - BCS of 5 or 8/9"
55
how do you measure obesity"
1. Weight - RBW= current weight/ optimal 2. Body mass index - BMI = body mass (kg)/height (m2) 3. Percentage fat - Around 15 – 20% is optimal in animals 4. Morphometric analysis - In animals the pelvic circumference may be used as it changes most with increasing or decreasing weight 5. Body condition score - Commonly based on a 5-point or a 9-point scale - Can be subjective…"
56
whats the consequences of obesity
"- dystocia- diffeculty birthing - difficulty breathing - reduced life expectancy - diabetes - CV disease - joint problems - increased risk under anaesthetic"
57
what are the risk factors of obesity
"- gender - neutering - activity - age - genetic - owner perception - human-animal bond"
58
what are the ways of controlling
"- A specific weight-reducing food might be recommended - Many of these diets contain a high fibre content which dilutes calories and reduces overall consumption - decrease calorie intake → increase exercise→ re-assessment - set a goal and time scale"