GI

Question 1

Metoclopramide

1. MOA
2. Onset, DOA, E 1/2t
3. Metabolism/PharmK
4. SE
5. Contraindications
6. Dosages

Answer 1

1. Dop-2 antagonist, 5HT-4 agonist, ↑ Ach in GI tract
2. 1-3 mins, 1-2 hours, 2-4 hours
3. Renal, 40% unchanged
4. Extrapyramidal effects, cramping
5. Parkinsons, bowl obstruction
6. 10-20 mg IV slowly

Question 2

Droperidol

1. MOA
2. Peak, DOA
3. Metabolism/PharmK
4. SE
5. Contraindications
6. Dosages

Answer 2

1. Dop-2 antagonist at CRTZ
2. 30 min, 12 hours
3. 75% renal, high Pb
4. Extrapyramidal effects, QT prolongation
5. Parkinsons, do not give w/ Reglan (synergistic)
6. 0.625 - 1.25 mg IV

Question 3

Zofran

1. MOA
2. Onset, DOA, E 1/2t
3. Metabolism/PharmK
4. SE
5. Contraindications
6. Dosages

Answer 3

1. 5HT antagonist at CRTZ
2. 30 mins, 4-8 hours, 3-4 hours
3. 95% Liver metabolism
4. AV block w/ Reglan, slight QT prolongation
5. SSRI/ MAOI, Reglan admin, liver disease
6. 4 - 8 mg over 2 min

Question 4

Phenothiazines

1. MOA
2. Onset, DOA, E 1/2t
3. Metabolism/PharmK
4. SE
5. Contraindications
6. Dosages

Answer 4

1. D2 and H1 antagonists
2. 3-5 mins, 4-6 hours, 9-16 hours
3. Liver metabolism
4. Sedation
5. Parkinsons, children <2, Liver disease
6. 6.25 - 12 mg IV