Gi Development Flashcards

(35 cards)

1
Q

What are the three layers of Gastrulation?

A

Ectoderm
Mesoderm
Endoderm

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2
Q

In gut formation, which layer wraps around the other two ?

A

Ectoderm

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3
Q

Which layer is the gut made up of?

A

Endoderm

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4
Q

What does the cloaca separate?

A

Bladder and rectal regions

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5
Q

The concentration of what sets up regionalisation?

A

Retinoic acid

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6
Q

What forms in areas where there is a lack of retinoids acid?

A

Pharynx

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7
Q

What forms in areas of high retinoic acid?

A

Colon

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8
Q

What else plays a role in regionalisation?

A

Mesoderm and endoderm interact

SHH

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9
Q

What is the pharynx formed of?

A

Top is ectodermal

Lower is endodermal

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10
Q

What joins to form the neck?

A

Pharyngeal arches and pouches

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11
Q

What does the 1st pair of pharyngeal pouches form?

A

Auditory cavities

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12
Q

What does the 2nd pair of pharyngeal pouches make?

A

Tonsils

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13
Q

What does the 3rd pharyngeal pouches form?

A

Thymus

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14
Q

What does the 4th pair of pharyngeal pouches make?

A

Parathyroid gland

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15
Q

What is the mesentery?

A

The stalk that attaches the gut tube to the fetus

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16
Q

What does the mesentery allow passage of into the GI?

A

Nerves blood vessels

17
Q

What is the septum transversum?

A

Mesenchyme in the embryo that forms the gut

18
Q

What does the ventral mesentery form?

A

Upper part of GI

19
Q

What does the liver split the ventral mesentery into?

A

Lesser omentum and falciform ligament

20
Q

What happens to the stomach as it grows?

A

It rotates 90 degrees moving the small intestine and pancreas

21
Q

What does canalisation do?

A

Reopens the lumen of the duodenum

22
Q

What happens if canalisation doesn’t happen?

A

Will cause a blockage leading to a build up of amniotic fluid

23
Q

What happens during mid gut development?

A

Rapid elongation
Looping
Herniated into umbilical cord for growing space

24
Q

What layer forms the liver pancreas and gall bladder?

25
What induces liver development?
Proximity to heart
26
What specifies development of hepatocytes?
Hepatocyte growth factor HGF
27
What do cholangocytes form?
Bile duct cells
28
How is the pancreas formed?
Ventral and dorsal buds rotate and join
29
Which bud forms the uncinate process of the pancreas?
Ventral
30
What stimulates the development of pancreas?
Notochord
31
If Ngn3 is present which cell type will form?
Endocrine
32
Why must baby’s get lipase from milk?
They cannot digest protein as pancreas only becomes functional as an adult
33
Why do GI cells constantly regenerate?
High throughput and thus attrition
34
How does gi maturation occur?
Cells move to top of villi and undergo anoikis
35
What is anoikis?
Cell death due to loss of attachment