GI drugs Flashcards
(107 cards)
Hepatitis A Vaccine: Mechanism of Action
Gamma globulin
Immunoglobulin: Mechanism of Action
Passive immunity to Hep A, for travel to endemic areas
Hepatitis B Vaccine: Mechanism of Action
Recombinant Vaccine, active immunity
PEGylated Interferon: Sub
HepB AND HepC
Tenofovir, Entecavir, Lamivudine
HepB only
Tenofovir, Entecavir: Mechanism of Action
Competitively decreases DNA polymerase, replication
PEGylated Interferon: Indication(s)
For all types of hepatitis C
Ribavirin: Indication(s)
For Hepatitis C genotype 2/3
Ribavirin: Mechanism of Action
Synthetic nucleoside analog
Ribavirin: Adverse Effects
causes anemia
Boceprevir, teleprevir: Indication(s)
For Hep C genotype 1
Boceprevir, telaprivir: Mechanism of Action
Protease inhibitors
Diuretics: Sub AND Indication(s)
Ascites (Cirrhosis, PHTN)
Diuretics: Mechanism of Action
Aldosterone inhibitor (aldactone) + loop diuretic (furosemide)
Diuretics: Adverse Effects
Gynecomastia (switch to amiloride or triamterene)
Diuretics: If ascites is refractory
Large volume paracentesis (LVP) or transjugular intrahepatic portosystemic shunt (TIPS)
Conivaptan, Tolvaptan: Indication
for decreased Na+ in Cirrhosis, PHTN
Conivaptan: Mechanism of Action
Vasopressin antagonists
Conivaptan, Tolvaptan: Adverse Effects
Cerebral edema
Nadolol, Propanolol: Indication
Varices in Cirrhosis and PHTN
Nadolol, Propanolol: Mechanism of Action
Beta blockers decreases portal vein inflow
Lactulose: Indication(s)
Hepatic encephalopathy
Lactulose: Mechanism of Action
Draws out NH3
Rifaximin: Indication(s)
Hepatic encephalopathy AND IBS-D