GI DRUGS!

Question 1

Sofosbuvir

Answer 1

Nu analog that blocks HCV RNA pol

Question 2

Ribavarin

Answer 2

Nu analog that blocks GTP synth and viral RNA capping

Question 3

Ledipasvir

Answer 3

blocks HCV 5 A phosphoprotein and therefore blocks Replication assembly, secretion of virus

Question 4

Paritaprevir

Answer 4

blocks HCV 3/4A serine protease therefore blocks viral protein processing

Question 5

Ritonavir

Answer 5

Boosts paritaprevir by blocking Cyp3A4

Question 6

Ombitasvir

Answer 6

blocks HCV5A phosphoprotein, therefore blocks rep/assembly/secretion of the virus

Question 7

Simeprivir

Answer 7

Blocks HCV 3/4A serine protease, therefore blocks viral protein processing

Question 8

HCV 2&3 Combos

Answer 8

Sofosbuvir + RIBAVARIN for 12w (HCV2) /24w (HCV3)

Question 9

HCV 1a Combos

Answer 9

1. Ledipasvir + Sofosbuvir for 12w
2. Paritaprevir + Ritonavir + Ombitasvir for 12w or 24w (w cirrhosis)
3. Sofosbuvir + Simeprivir + Ribavarin for 12w or 24w (w cirrhosis)

Question 10

HCV 1b Combos

Answer 10

1. Ledipasvir + Sofosbuvir for 12w
2. Paritaprevir + Ritonavir + Ombitasvir for 12w or (+ Ribavarin w cirrhosis)
3. Sofosbuvir + Simeprivir for 12w or 24w (w cirrhosis)

Question 11

HCV 4 Combos

Answer 11

1. Ledipasvir + Sofosbuvir for 12w
2. Paritaprevir + Ritonavir + Ombitasuvir + Ribavarin (12w)
3. Sofosbuvir + RIBAVARIN (24w)