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Flashcards in GI DRUGS! Deck (11)
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1
Q
Sofosbuvir
A
Nu analog that blocks HCV RNA pol
2
Q
Ribavarin
A
Nu analog that blocks GTP synth and viral RNA capping
3
Q
Ledipasvir
A
blocks HCV 5 A phosphoprotein and therefore blocks Replication assembly, secretion of virus
4
Q
Paritaprevir
A
blocks HCV 3/4A serine protease therefore blocks viral protein processing
5
Q
Ritonavir
A
Boosts paritaprevir by blocking Cyp3A4
6
Q
Ombitasvir
A
blocks HCV5A phosphoprotein, therefore blocks rep/assembly/secretion of the virus
7
Q
Simeprivir
A
Blocks HCV 3/4A serine protease, therefore blocks viral protein processing
8
Q
HCV 2&3 Combos
A
Sofosbuvir + RIBAVARIN for 12w (HCV2) /24w (HCV3)
9
Q
HCV 1a Combos
A
1. Ledipasvir + Sofosbuvir for 12w
2. Paritaprevir + Ritonavir + Ombitasvir for 12w or 24w (w cirrhosis)
3. Sofosbuvir + Simeprivir + Ribavarin for 12w or 24w (w cirrhosis)
10
Q
HCV 1b Combos
A
1. Ledipasvir + Sofosbuvir for 12w
2. Paritaprevir + Ritonavir + Ombitasvir for 12w or (+ Ribavarin w cirrhosis)
3. Sofosbuvir + Simeprivir for 12w or 24w (w cirrhosis)
11
Q
HCV 4 Combos
A
1. Ledipasvir + Sofosbuvir for 12w
2. Paritaprevir + Ritonavir + Ombitasuvir + Ribavarin (12w)
3. Sofosbuvir + RIBAVARIN (24w)