gi drugs Flashcards Preview

GI Pathogens > gi drugs > Flashcards

Flashcards in gi drugs Deck (14):
1

misoprostol: MOA and adverse

inhibit adenylate cyclase in parietal cells, thereby decreasing acid secretion (recall that h2 receptor signals through CAMP pathway in parietal cell); adverse: uterine contractions, diarrhea

2

sucralfate

aloh3+sulfated sucrose to polymerize in presence of acid to cover epithelium/ulcer crater, and induce release of PGs. Rarely used. Adverse: can release aluminum and cause constipation (aluminum causes constipation)

3

colloidal bismuth

prevents diffusion of h+ to the mucosa. bacteriocidal also. travelers diarrhea and h pylori; adverse: black tongue, black stools, tinnitus

4

tx of h pylori

omeprazole, amoxicillin, clarithromycin

5

side effects of CaCO3, AlOH3, MgOH2

CaCO3: hypercalcemia, rebound acid
aloh3: constipation, hypophosphatemia, renal
mgoh2: diarrhea, hyporeflexia, renal

6

metoclopramide moa and adverse

D2 antagonist (inhibits gastric smooth muscle relaxation/LES relaxation) and 5HT4 agonist (increase cAMP) ultimately causing increased intestinal mobility
adverse: tardive dyskinesia, extrapyramidle

7

erythromycin MOA and adverse

mimics motilin, increasing LES pressure, contractility of small bowel and stomach but not colon
adverse: qt prolongation

8

which H2 receptor antagonist is assoc. with cyp 450 induction and gynecomastia?

cimetidine

9

loperamide

diphenoxylate atropine (lomotil)

anti diarrhea mu opioid agonists (decrease intracellular cAMP); increase muscle tone; reduce peristalsis

10

alosetron

tx for diarrhea via 5ht3 antagonism. rare: ischemic colitis

11

lubiprostone moa

prostaglandin analogue: stimulates AC to make cAMP and activate chloride channel. (like cholera); treats constipation

12

linaclotide

guanylate cyclase agonist increases cGMP, leading to secretory anions and h2o. also helps pain bc extraceullar cGMP modulates nerves.

13

alvimopan

mu opioid antagonist to cause ultimate raising of cAMP.. given to tx postop ileus

14

methylnaltrexone

opioid induced constipation tx. mu opioid antagonist.