GI Tract Meds and Peptic Ulcer Disease Therapy

Question 1

what does Hal do

Answer 1

decrease stomach pH

Question 2

what does pepsin do

Answer 2

digests protein

Question 3

stimulators of digestive enzymes

Answer 3

ACH, gastrin, histamine

Question 4

aggressive factors of peptic ulcer disease

Answer 4

HCl and pepsin

Question 5

defensive factors of peptic ulcer disease

Answer 5

prostaglandins

mucosal barrier and sodium bicarbonate

Question 6

ulcer formation

Answer 6

HCl and enzymes concentrated
disruption of stomach lining
erosion of mucosa

Question 7

predisposing factors of ulcers

Answer 7

increased HCl production, glands unable to produce mucus, stress, increased vagus nerve stimulation, alcohol, smoking, drugs, genetic

Question 8

helicobacter pylori (H. pylori)

Answer 8

most common cause of peptic ulcers, bacterial infection, acquired through contaminated water, poorly washed food, uncooked food

Question 9

second most common cause of ulcers

Answer 9

NSAIDs

Question 10

GERD

Answer 10

heartburn

gastric acid washes back into esophagus

Question 11

ulcer management

Answer 11

lifestyle management, discontinue NSAIDs, drug therapy, surgery, decrease foods that cause ulcers

Question 12

MOA of H2 receptor antagonists

Answer 12

bind to H2 receptor blocking histamine from binding and decrease production of gastric acid and pepsin

Question 13

what do all H2 receptor antagonists end in

Answer 13

tidine

Question 14

MOA of PPIs

Answer 14

inhibit ATPase change, reducing gastric acid secretion

Question 15

what do PPIs end in

Answer 15

prazole

Question 16

Nexium® vs Prilosec®

Answer 16

Nexium® has greater oral bioavailability, longer half life, lower plasma clearance, and faster heal rate
Prilosec® has interaction with warfarin

Question 17

MOA of antacids

Answer 17

neutralize gastric acidity

Question 18

what do all antacids end in

Answer 18

hydroxide or carbonate

Question 19

MOA of protectants

Answer 19

coats ulcer and inhibits pepsin activity

Question 20

MOA of prostaglandins

Answer 20

inhibit gastric acid secretion

Question 21

MOA of prokinetics

Answer 21

enhances action of ACH, prevents reflux of acid, promotes gastric emptying

Question 22

diarrhea

Answer 22

increased intestinal motility

loose stools

Question 23

constipation

Answer 23

decreased intestinal motility

hard stools, incomplete emptying, less than 3 bowel movements per week

Question 24

drug classes for anti-diarrheals

Answer 24

anticholinergics, opined derivatives, absorbents, antibiotics