GK24 1 Flashcards

1
Q

When did Justinian become emperor of Byzantium?

A

527 AD

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2
Q

What is ODAC in the FDA?

A

Oncology Drugs Advisory Committee

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3
Q

Who took over the Sumerian empire? Year?

A

Sargon the Great— it became the Akkadian Empire

2334 BC

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4
Q

Why did Caesar end up having an affair with Cleopatra in the first place?

A

After the battle of Pharsalus (48 BC) Pompey fled to Egypt and Caesar chased him there; that’s how he met Cleopatra

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5
Q

Did Trump want to go to the capitol on January 6th?

A

Yes but his secret service driver refused to take him

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6
Q

During what years did Alexander the Great reign?

A

336-323 BC

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7
Q

Full name of Ali the heir to Shiite Islam

A

Ali ibn Abi Talib

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8
Q

Word for a spartan slave

A

Helot

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9
Q

Where was Krakatoa?

A

Volcano between Sumatra and Java in Indonesia

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10
Q

Who was appointed princeps after Nero?

A

Vespasian 69 AD (Galba for a year briefly before)

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11
Q

What does Calvary mean? Other name?

A

Latin for “The Place of the Skull”
Golgotha

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12
Q

What is the Dome of the Rock?

A

A mosque over a rock where Muhammad is said to have ascended into heaven (Jerusalem)

But he died in Saudi Arabia

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13
Q

Who is the owner/creator of My Pillow?

A

Mike Lindell

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14
Q

When did the FDAs accelerated approval mechanism begin?

A

1992 (for AIDS drugs)

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15
Q

Name of the needle at the neck of Paul Atreides in Dune

A

The Gom Jabbar

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16
Q

Name of ship that took Napoleon to St. Helena

A

HMS Bellerophon

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17
Q

Name of the chief god of Babylon?

A

Marduk

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18
Q

In early Christianity what was the Arian controversy?

A

Arianism stated that Jesus was not divine but created by god; this was resolved at the council of Nicaea in 325 AD

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19
Q

Word for the priests or magicians in ancient Celtic religion

A

Druid

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20
Q

Who conquered all of the Arabian peninsula after the death of Muhammad?

A

Abu Bakr - his successor (Sunni Branch)

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21
Q

Natives of Arrakis in Dune

A

Fremen

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22
Q

What would Herodotus have called the Danube River?

A

Ister River

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23
Q

The Horn of Africa is largely directly south of which country?

A

Yemen

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24
Q

Where was the Ancient Greek region of Ionia?

A

Western Turkey and the nearby Aegean Islands

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25
Q

Ancient name for the Dardanelles strait?

A

Hellespont

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26
Q

What wars did Herodotus write about?

A

Persian Wars

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27
Q

What year was the Council of Nicaea?

A

325 AD

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28
Q

Who wrote “The Ecclesiastical History of the English People”?

A

Bede (The Venerable Bede)

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29
Q

Who was the last king of Judea who rebelled against Nebuchadnezzar and was taken to Babylon in captivity?

A

Zedekiah

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30
Q

Where was the ancient area of Lydia?

A

Western Anatolia

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31
Q

In what battle did Julius Caesar defeat Pompey?

A

Pharsalus 48 BC

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32
Q

In what year did the Dutch purchase Manhattan?

A

1626

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33
Q

Where did the $50,000/QALY rule come from?

A

1970s Medicare for covering dialysis for ESRD but now w/ inflation the numbers are changing

100,000 or less good
175,000 or more not

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34
Q

Clovis was the first king of all of the Franks and his descendants would take their name from ______

A

Merovech a legendary warrior (Merovingian dynasty)

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35
Q

When was the fall of the western Roman Empire?

A

476 AD Odoacer deposed Romulus Augustulus

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36
Q

What city is located on the Orontes River?

A

Antioch

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37
Q

Who was the first American president to have been impeached?

A

Andrew Johnson

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38
Q

Jews and Arabs claim descent through Abraham how?

A

Jews through Isaac
Arabs through Ishmael

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39
Q

What is legerdemain?

A

Trickery; skillful use of one’s hands when performing conjuring tricks

Sleight of hand

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40
Q

Meaning of mendacity

A

Untruthfulness

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41
Q

Two major types of cost for drug companies?

A

Manufacturing costs

Research and development

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42
Q

What happened to Mycenaean culture after the sack of Troy?

A

Began to severely decline and eventually essentially end

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43
Q

Word for a spartan warrior

A

Hoplite

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44
Q

What year was the Gadsden Purchase?

A

1853

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45
Q

Other name for the pre-Socratic philosophers

A

Ionian rationalists

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46
Q

Who is credited with spreading Christianity to Ireland?

A

St. Patrick (Patricius)

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47
Q

About how old was Romulus Augustulus when he was deposed by Odoacer in 476 AD?

A

He was maybe 10-12 years old

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48
Q

What ancient culture is known for producing ziggurats?

A

Sumerians

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49
Q

Where did tomatoes originate?

A

Andes mountains then mainly developed in Mexico

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50
Q

Where is the Golden Horn?

A

A port/body of water that wraps around Constantinople/Istanbul near the Bosporus strait

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51
Q

Who did Marcus Aurelius appoint as his successor?

A

His son Commodus (177 AD) but he was a bad emperor like Caligula and Nero

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52
Q

In Islam, what is “the umma”?

A

The whole community of Muslims bound by religion

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53
Q

What country is north of Syria?

A

Turkey

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54
Q

When were the A, B, AB, and O blood groups first described?

A

1901 by Karl Landsteiner

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55
Q

Which countries are between Iran and India?

A

Afghanistan and Pakistan

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56
Q

In what city did Trump launch his 2024 campaign?

A

Waco, Texas

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57
Q

Who is the disease Brucellosis named after?

A

Major David Bruce

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58
Q

When did John Bennett publish his first case report on a patient dying from a suppuration of blood?

A

1845

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59
Q

What name would Christopher Columbus have answered to?

A

Cristobal Colon

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60
Q

Which Byzantine emperor collected the laws from several centuries and unified them into a code?

A

Justinian 528 AD

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61
Q

When were the Jesuits founded?

A

1540 in Montmartre by Ignatius Loyola

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62
Q

Which Roman emperor outlawed paganism?

A

Theodosius (392-393)

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63
Q

Main religion of the Persian empire

A

Zoroastrianism

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64
Q

In which battle did Octavian defeat Mark Antony? Year?

A

Actium (a naval battle); 31 BC

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65
Q

What disease was once known as Malta fever?

A

Brucellosis

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66
Q

Origin of the word “antigen”?

A

Antibody-generating

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67
Q

When was ipilimumab approved for melanoma?

A

2011

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68
Q

What is the Hellespont?

A

Ancient name for the Dardanelles strait

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69
Q

Before Trump who was the last president to skip out on their successors inauguration?

A

Andrew Johnson 1869 didn’t attend Ulysses S Grant

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70
Q

Where was the ancient kingdom of Numidia?

A

Basically in modern day Algeria

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71
Q

Word for high priest of the Roman state religion (ie pagan before Christianization)

A

Pontifex Maximus

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72
Q

Ctesiphon was an ancient city of which empire?

A

Persian

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73
Q

Where was Saul (Paul) traveling from on his way to Damascus?

A

Jerusalem

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74
Q

Gilgamesh was king of which Sumerian city?

A

Uruk

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75
Q

In China the first settlements began around this river

A

Yellow River

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76
Q

The Jewish King David had an affair with which woman?

A

Bathsheba —had her husband killed so he could marry her

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77
Q

In ancient times the Minoans of Crete were frequently subjected to which form of natural disaster?

A

Earthquakes and subsequent tsunamis

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78
Q

The Maccabee revolt took place when Judea was under control of which empire?

A

Seleucid (a fragment of the Macedonian empire)

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79
Q

Name of the epic poem by Hesiod that tells the genealogies of the Greek gods

A

Theogony

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80
Q

When was modern day Turkey founded? First president?

A

1923; Mustafa Kemal Ataturk (Ataturk)

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81
Q

What were Columbus’ 3 ships?

A

Nina, Pinta, Santa Maria

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82
Q

“Ask, and it shall be given you” is a teaching from Jesus where?

A

Sermon on the Mount

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83
Q

When does the supreme court begin its new term?

A

The first Monday of October

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84
Q

On the Rosetta Stone, what language is written next to the hieroglyphs to decode them?

A

Greek

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85
Q

This is the earliest collection of Indian hymns

A

Rig Veda

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86
Q

Who was emperor of Rome before Constantine?

A

Diocletian

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87
Q

What does episcopal literally mean?

A

Episkopos = overseer (over seeing) —referring to bishops overseeing

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88
Q

Who was the father of Chinese history?

A

Sima Qian

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89
Q

After the Carthaginians were defeated and removed from Sicily in the first Punic war, they set up a new base of operations in _____

A

Iberia

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90
Q

In what decade did the FDA start using black box warnings?

A

1970s

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91
Q

What is fiat?

A

A formal authorization or proposition

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92
Q

Muhammed was from what tribe?

A

Quraysh

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93
Q

The Roman republic began in what year?

A

509 BC (Rome founded 753 BC)

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94
Q

What is the northeast bit of the Black Sea called?

A

Sea of Azov

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95
Q

Ashurbanipal was king of which civilization?

A

Assyrian

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96
Q

This is the shortened version of the Kingdom of the South Saxons

A

Sussex

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97
Q

Why is radioactive strontium dangerous for the bone marrow?

A

It is similar to calcium and so gets taken up by bone and releases beta particles

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98
Q

What were the names of the Gracchus brothers in the Roman Republic?

A

Tiberius and Gaius

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99
Q

A myth states that the Dutch bought Manhattan from the Indians for _____

A

24 dollars

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100
Q

Yemen based terror group backed by Iran?

A

Houthis (Shia)

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101
Q

Where was the city of Chichen Itza?

A

Yucatán Peninsula

102
Q

What are the evil spirits in Zoroastrianism called?

A

Daevas

103
Q

When did Diocletian become emperor of Rome?

A

284 AD

104
Q

Where was Sumer located?

A

Southern bit of Iraq

105
Q

What is the name of the film of the JFK assassination that is considered to be the most complete?

A

The Zapruder Film

106
Q

Meaning of perfunctory

A

Carried out with a minimum of effort or reflection

107
Q

What were provincial governors of the ancient Persian empire called?

A

Satraps

108
Q

Where was Herodotus from?

A

Halicarnassus

109
Q

In 1663 bc, a people called the Hyksos took over which civilization?

A

Egypt

Hyksos were a Semitic people which may partially explain the prejudice of the Egyptians against the later Semitic Hebrews

110
Q

Where was Thrace?

A

North of Aegean in modern day Greece and Bulgaria

111
Q

What are arrears?

A

Money that is owed and should have been paid

112
Q

The phrase “a sea change” to describe a transformation comes from where?

A

Shakespeare’s Tempest

113
Q

Which emperor of Rome split the empire into a western and eastern half ruled by co-emperors?

A

Diocletian

114
Q

What was the argument that the bishop of Rome should be the head of all bishops?

A

That the bishop of Rome is the successor of Peter

115
Q

King Midas was from where?

A

Phrygia

116
Q

What year was Julius Caesar assassinated?

A

44 BC

117
Q

Who wrote Rendezvous with Rama?

A

Arthur C Clarke

118
Q

Nebuchadnezzar was a king of which empire?

A

Babylonian

119
Q

In a tax assessment on a house and land what is the house referred to as?

A

The improvement on the land

120
Q

Etruscans lived in the kingdom of ______

A

Etruria

121
Q

What did Cleopatra and Mark Antony do when Octavian/Augustus marched to Egypt?

A

Commit suicide (30 BC)

122
Q

When Octavian/Augustus consolidated power after defeating Mark Antony in 31 BC, he became known as Princeps which means ______

A

First Citizen (later translated as Prince)

123
Q

In which bloody battle in the second Punic war did Hannibal’s troops slaughter 65,000 Romans

A

Cannae

124
Q

What year did Hugo Chavez die?

A

2013

125
Q

What is the home world of House Harkkonen in Dune?

A

Geidi Prime

126
Q

The word Semite derives from which son of Noah?

A

Shem

127
Q

Who was Trump’s first attorney general?

A

Jeff Sessions

128
Q

Who is Viktor Orban?

A

Prime Minister of Hungary 2024

129
Q

What “giant of the forest” does Gilgamesh have to fight to get wood to secure his walls?

A

Humbaba

130
Q

Which Aztec city was at the site of Mexico City?

A

Tenochtitlan

131
Q

According to Genesis, God made a covenant with Abraham promising what as The Promised Land?

A

Canaan (recall Abraham from Ur in Sumeria)

132
Q

On 1/11/24 which two countries targeted the houthis in Yemen due to their attacks on shipping in the Red Sea?

A

US and UK

133
Q

What does centrifugal refer to?

A

Moving away from the center

134
Q

First archaeologically and historically certain dynasty of China? Who was after?

A

Shang then Zhou

135
Q

What did Cain say when god asked him where Abel was after he murdered him?

A

I know not; am I my brother’s keeper?

136
Q

When did van Leeuwenhoek first describe red blood cells under the microscope?

A

1674

137
Q

In what year did Rudolph Virchow die?

A

1902

138
Q

When did Muslims first capture Jerusalem?

A

637 AD only 5 years after Muhammad died

139
Q

When was the SYNDROME of polycythemia vera first described and by whom?

A

1903–Osler

140
Q

What was the name of the “barbarian” tribe that invaded the Akkadian empire between 2278 bc and 2154 bc?

A

The Gutians

141
Q

Which Persian king was defeated by the Greeks at Marathon in 490 bc? Which came back in 480?

A

Darius I (then died 486)
Xerxes his son came back in 480

142
Q

What country had a large earthquake on New Years Day 2024?

A

Japan

143
Q

Where was the Frankish kingdom of Clovis?

A

Mostly in Gaul

144
Q

Greece is located in what direction from Italy?

A

East

145
Q

First king of the Merovingian dynasty

A

Clovis (though takes name from Merovech-a famous warrior)

146
Q

Which group invaded Crete and the Minoans in 1450 bc?

A

Mycenaeans

147
Q

This music style was a forerunner of Jazz and was popular in America 1899-1917

A

Ragtime

148
Q

When was aniline dye staining by Ehrlich done with description of neutrophils, basophils, and eosinophils?

A

1878

149
Q

Cyrus the Great was king of which civilization?

A

Persian

539-530 BC (before Darius and Xerxes)

150
Q

Who was Peter Stuyvesant?

A

A governor of New Netherland/New Amsterdam before the English took over

151
Q

The Mahabharata tells the story of a civil war in the Kuru clan between which two factions?

A

Kairavas and Pandavas

152
Q

Surrogate endpoints stand in contrast to _____

A

Clinical endpoints

153
Q

Official name of the Jesuits

A

The Society of Jesus

154
Q

Name of the Roman province on the Iberia peninsula

A

Hispania

155
Q

Approximately how long ago was Pangaea?

A

~250 million years

156
Q

The Peloponnesian War officially began in this year

A

431 BC and would last about 30 years

157
Q

Where was Canaan?

A

Ancient Palestine area west of Jordan River

158
Q

When was the first description of von Willebrand disease by von Willebrand?

A

1926

159
Q

What is the difference between pharma and biotech?

A

Pharma focuses on making small molecules etc

Biotech is more about molecules produced by living cells

160
Q

Who are the first two patriarchs of the Old Testament?

A

Abraham and Isaac (his son)

His other son—Ishmael- believed to be patriarch of Arabs

161
Q

Who was Confucius most famous pupil?

A

Mencius

162
Q

What 313 AD agreement did Constantine proclaim that made Christianity legal in the Roman empire?

A

The Edict of Milan

163
Q

What was Mark Antony’s actual name?

A

Marcus Antonious

164
Q

Who is Rome named after?

A

Romulus since he survived after killing Remus

165
Q

Who is the archetypal first man of the Hindu religion—survivor of the great flood and father of the human race?

A

Manu

166
Q

When did the Warring States period begin in China?

A

403 BC

167
Q

What Roman plague occurred during Galen’s lifetime? Years?

A

The Antonine Plague (likely smallpox) 165-180 AD

168
Q

Who was the last Lydian king? Who defeated him?

A

Croesus; Cyrus the Great (Persia)

169
Q

Where did the Angles and Saxons originally come from?

A

The area between Germany and Denmark

Invited to help fight northern foes by Vortigern in 445 AD

170
Q

In what year did multiple reports emerge on the efficacy of nitrogen mustards for treatment of leukemia and lymphoma?

A

1946–the studies took place during WW2 but not published after due to security reasons hence why multiple groups published all at once

171
Q

One could consider the Enlightenment as occurring between which two revolutions?

A

The Glorious Revolution (1688) and the French Revolution (1789)

172
Q

Where is Christs supposed empty tomb?

A

Jerusalem’s Church of the Holy Sepulcher

173
Q

What was Sidney Farbers original profession?

A

Pediatric pathologist

174
Q

The Ishtar Gate was outside of which ancient city?

A

Babylon

175
Q

Why did the Jews leave Canaan for Egypt in the first place?

A

Due to famine and Egypt was well watered (Nile)

Then the pharaoh enslaved them

176
Q

Who is the evil god or “chief daeva” in Zoroastrianism?

A

Ahriman or Angra mainyu

177
Q

Where was Ephesus? Modern name?

A

Greek city in western Turkey; Selcuk

178
Q

Officially announced on May 15, 2020 this program sought to quickly crank out COVID vaccines

A

Operation Warp Speed

179
Q

From what city and civilization did Abraham come from?

A

Ur—Sumerian (there was already a system of gods where he grew up)

180
Q

What was the dichotomy that led to Sunni and Shi’ite Muslims after Muhammad’s death in 632 AD?

A

Abu Bakr—close friend of Muhammad took over caliphate = Sunni

Those who contest it think should be Muhammad’s son in law—Ali (Ali ibn Abi Talib)

181
Q

The Aegean Sea is named after whom?

A

King Aegeus (father of Theseus)

182
Q

Though not one of the twelve apostles, this man is often considered an apostle due to his role in spreading Christianity

A

Paul (Saul of Tarsus)

183
Q

Where is Ravenna?

A

Northeastern coast of Italy on Adriatic

184
Q

Under whose reign were Peter and Paul killed in the Roman empire?

A

Nero

Peter crucified
Paul beheaded

185
Q

Who were the Lombards?

A

A Germanic people who conquered most of the Italian peninsula between 568-774 AD

186
Q

Similar to later manifest destiny, ancient Chinese kings had ________ to justify their ability to take over nearby tribes etc

A

The Mandate of Heaven

187
Q

Collectively, religious writings accepted as books of the Bible by some groups but not others are called _____

A

Apocrypha

188
Q

The nickname for NYC, Gotham, was originally used by whom?

A

Washington Irving

189
Q

Since the time of Constantine, gladiatorial games were slowly replaced by _______

A

Chariot Racing—less associated with old Roman Gods

190
Q

What was the purpose of the council of Nicaea in 325 AD?

A

To deal with the controversy of Arianism which said Christ was not divine; Nicene Creed states that he is

Basically to determine the divinity status of Jesus

191
Q

What were “political machines” such as Tammany Hall in America?

A

Institutions run by “bosses” who would coerce votes. Offer jobs and services to immigrants in exchange for votes

192
Q

Meaning of the verb ensorcel

A

To fascinate or enchant (literary)

193
Q

Who was Roman emperor after Tiberius?

A

Caligula

194
Q

Gotham is old Anglo-Saxon for ______

A

Goats Town

195
Q

When did Columbus return to Spain after the initial discovery of the New World?

A

March 1493

196
Q

Most famous section of the Mahabharata

A

Bhagavad Gita

197
Q

What year was Kwanzaa created?

A

1966

198
Q

Where was the kingdom of Goguryeo located?

A

Korean Peninsula

199
Q

Where is the Sea of Azov?

A

Northeast bit of Black Sea by Crimea

200
Q

How long after Darius was defeated at Marathon until his son Xerxes came back and fought at Thermopylae?

A

10 years

Marathon 490 bc
Thermopylae 480 bc

201
Q

What is the chief source of natural rubber?

A

Latex of the rubber tree

202
Q

Who is this?

A

William Halsted

203
Q

Which Egyptian king changed from worshipping the Sun God to the Sun itself?

A

Amenhotep went from worshipping Ra to worshipping Aten (the sun itself)

Changed name to Akhenaten

204
Q

What mountain range is east of the Tigris and is in modern day Iran?

A

Zagros Mountains

205
Q

Around when was the battle of Troy? What about the Persian Wars?

A

1250 BC and Persian Wars were 490 then again in 480 so nearly 800 years apart

206
Q

Name of mountain pass between Pakistan and India

A

Khyber Pass

207
Q

In Christianity, what was the Annunciation?

A

Announcement by the angel Gabriel that Mary would bear a son despite being a virgin

208
Q

Which Goth sacked Rome in 410 AD?

A

Alaric the Visigoth

209
Q

Who was the first king of all the Franks?

A

Clovis 496 AD

210
Q

What did Virchow call leukemia in 1845? 1847?

A

Weisses Blut; changed name to leukemia

211
Q

What was the name of the city that Constantine would turn into Constantinople?

A

Byzantium

212
Q

Where was Hadrian’s Wall?

A

Separated the wild north from the civilized part of Roman Britannia

213
Q

Who is the activist who started the #blacklivesmatter hashtag? Why? Year?

A

Alicia Garza and Patrisse Cullors 2013 because George Zimmerman acquitted after Trayvon Martin killed

214
Q

Who was second emperor of Rome —after Augustus/Octavian?

A

Tiberius (was emperor when Christ crucified)

215
Q

In radiation, a rad is an acronym for _____

A

Radiation absorbed dose

216
Q

What are the native people of Hispaniola referred to as (ie pre Columbus)?

A

Taino

217
Q

When was anesthesia with ether first publicly demonstrated?

A

1846 at MGH

218
Q

When was the first successful blood transfusion by Blundell?

A

1818

219
Q

Which Assyrian king collected over 20,000 Clay tablets in his library at Nineveh?

A

Ashurbanipal

220
Q

January 2024 an Alabama Inmate was executed in what new manner?

A

Nitrogen gas

221
Q

What does Punjab mean?

A

5 rivers

222
Q

Who did Constantine defeat at the Battle of Milvian Bridge? Year?

A

Maxentius; 312

223
Q

494 bc Roman republic- what was the plebeian secession?

A

The first recorded strike—plebeians decided to walk out of the city and camp on a nearby Sacred Mount

224
Q

The Age of Iron in India is called ______ and supposedly began in _____ year

A

Kali Yuga—supposedly beginning 3102 BC

225
Q

Where were the Vandals from?

A

North Africa

226
Q

Last founding father to be a president?

A

James Monroe #5

227
Q

Which Roman emperors name means “little boots”?

A

Caligula

228
Q

Which Jewish prophet was a counselor to the king of Babylon during the Babylonian exile?

A

The prophet Daniel

229
Q

Where was Assyria (Assur city) in relation to Babylon?

A

North; both in modern day Iraq

230
Q

Where was the Hittite empire?

A

Basically in modern day Turkey

231
Q

Origin of the word cyclosporine?

A

It is cyclical and obtained from fungal spores (Trichoderma polysporum)

232
Q

Why were Spartan boys deliberately not fed enough food to survive?

A

To teach them to be resourceful and sneak out at night to hunt or steal food as these would be useful skills some day in battle

233
Q

Who were the first three KINGS of Israel?

A

Saul then David then Solomon

Solomon constructed the large temple

234
Q

When was RECIST first published?

A

2000—Response Evaluation Criteria in Solid Tumors

235
Q

Who was Justinians wife?

A

Theodora—an actress/prostitute

236
Q

Historically, health economists have considered how much per QALY as a fair price?

A

50,000/QALY

Now more like 100,000-175,000

237
Q

On his podcast, who said on January 5th 2020 “All hell is going to break loose tomorrow”?

A

Steve Bannon

238
Q

Where does paclitaxel come from?

A

Pacific Yew (Taxis brevifolia)

239
Q

What is the nightly meal that breaks the Ramadan fast called?

A

Iftar

240
Q

During the exodus, Moses divided up the Israelites into 12 tribes based upon what?

A

Which great grandson of Abraham they traced their lineage to

(this was 600 years after Abraham)

241
Q

What is the name of the novella on which The Thing is based?

A

“Who Goes There?”

The expanded version is “Frozen Hell”

John W Campbell

242
Q

The Akkadian city of Akkad was really called _____

A

Agade—Akkad was a Greek corruption

243
Q

What does Nestorian Christianity state?

A

Christ has two distinct natures —human and divine; Nicene Christianity states fully divine

244
Q

Capital city of Hittite empire

A

Hattusas

245
Q

Hammurabi was a king of which ancient city?

A

Babylon

246
Q

What does pH stand for?

A

Potential of hydrogen or power of hydrogen

247
Q

When people tried to assassinate Muhammed in 622 and he fled from Mecca, this was called ______

A

The Hijirah from Mecca to Medina

248
Q

The Persian army of Darius was defeated by the Greeks at what battle? Who was Darius’ son?

A

Marathon
Xerxes who would come back

249
Q

Who was the first pope? Year?

A

Leo the Great 445 AD

There had been prior bishops of Rome but he was the first to be called pope

250
Q

Meaning of gainsay

A

To deny or contradict

You cannot gainsay the impact of religion