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6.Glaucoma Block > Glaucoma Medications > Flashcards

Glaucoma Medications Flashcards

(64 cards)

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1
Q

3 options Choice for glaucoma

A

Medication
Surgery
Laser

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2
Q

7 types of anti glaucoma medications

A

ABCCHPR

1.Adrenergic
2.Beta Blocker
3.CAI
4.Cholinergic
5.Hyperosmotic
6.Prostaglandin
7.ROCK

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3
Q

3 Common Preservative in Glaucoma Medications

A
  1. BAK
  2. Purite
  3. Sofzia
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4
Q

Glaucoma medications contain BAK

A

ALTXC

Alphagan
Lumigan
Timoptix
Trusopt
Xalatan
Cosopt
Combigan

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5
Q

Glaucoma med contain Purite

A

Alphagan P

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6
Q

SofZia

A

Travatan Z

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7
Q

4 Mechanism Pathway for anti glaucoma

A

1.Trabecular Outflow
2.Episcleral Venous Pressure
3.Uveoscleral Outflow
4.Aqueous Humor Outflow

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8
Q

Adrenegic Agonist
Beta Blocker
CAI

Mechanism of Action ?

A

1.Aqueous Humor inflow

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9
Q

Example of Non selective
Adrenergic Agonis ( Alpha and Beta )

A

Dipivefrin
Epinephrine

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10
Q

Example of Selective Alpha 2 Agonist

A

Apraclonidine
Brimonidine ( Alphagan )

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11
Q

IOP Percent of Non selective Alpha Peak and washout

A

15-20 %
peak 12-24
Washout 7-14 days

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12
Q

IOP Percent of Alpha 2 , Peak , and Washout

A

20-30 %
Peak 1-2 hrs
Washout 7-14 days

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13
Q

Side effects of Non selective Adrenergic Agonist

A

Adrenochrome deposit
Follicular Conjunctivitis

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14
Q

Side effects of selective Adrenergic agonist

A

Follicular Conjunctivitis

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15
Q

Alphagan IOP Decrease Peak and Washout

A

20-30 % ,
Peak 2 hrs
Washout 7-14 days

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16
Q

Alphagan most important systemic side effects

A

Depression

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17
Q

Different of Alphagan and Alphagan P

A

Less Severe side effect

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18
Q

Non Selective Beta Adrenergic Drug antagonist example

A

Timolol ( Glauco Oph )
Cartelol
Levobunolol
Metipranolol

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19
Q

Selective Beta Adrenergic Drug
( Aqueous B2 )

A

Betaxolol

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20
Q

Non Selective Beta Adrenergic antagonist side effect both local and systemic

A

Local
- blurred vision
- Irritate
- Punctate keratitis
Systemic
- Bronchospasm
- MG exarcebation

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21
Q

Non Selective Beta Adrenergic antagonist IOP Decrease

A

20-30 %
Peak 2-3 hrs
Washouty 1 month

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22
Q

Example of CAI ?

A

1.Brinzolamide ( Azopt )
2.Dorzolamide ( Trusopt )

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23
Q

CAI IOP lowering peak and Washout

A

IOP 20-30 %
Peak 2-3 hrs
Washout 48 hrs

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24
Q

Local and Statemic side effects of CAI

A

Local
- Induced myopia + Blurred Vision

Systemic
- Bitter taste

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25
Prostaglandin Drug Example
1.Latanoprost ( Xalatan and Lanotan ) 2.Travoprost 3.Bimatoprost ( Lumigan ) 4.Tafluprost
26
Prostaglandin Local side effects ?
Anterior Uveitis PAP Exacerbation of Herpes Keratitis
27
Prostaglandin systemic side effects ?
Flulike symptoms Joint pain
28
Prostaglandin IOP reduction peak and washout
25-32 % Peak 10-14 hrs Washout 4-6 wks
29
Dosing of Prostaglandin
Once daily
30
Latanoprost Binatoprost Travorpost Latanoprostene bunod MOA
UV + Conventional
31
Tafluprost MOA
UV outflow
32
Prostaglandin important ocular side effect ?
Uveitis PAP Exacerbation of Herpes Keratitis
33
CAI dosing
BID TID
34
Beta blocker Dosing
OD , BID
35
Adrenergic Dosing
BID TID
36
Example of Cholinergic agonist
Direct - Pilocarpine - Cabachol Indirect - Echothiophate iodine
37
Cholinergic ( Parasym , Miotic ) IOP peak and washout
IOP 15-25 % Peak 2 hrs Washout 48 hrs
38
Dosing of Cholinergic Agent
bid - qid
39
Combination of Glaucoma is what group ?
Betablocker + Prostaglandin Betablocker + CAI Betablocker + Alpha adrenergic agonist
40
Betablocker + Xalatan ?
Xalacom
41
B + Travatan ( Travoprost ) ?
Duotrav
42
B + Lumigan ( Bimatoprost )
Ganfort
43
B + Taflotan (Tafluprost )
Tapcom
44
B + Brinzolamide ?
Azarga
45
B + Dorzolamide ?
Cosopt
46
B + Brimonidine ?
Combigan
47
Alpha adrenergic + CAI ?
Brimonidine + Brinzolamide = Simbrinza
48
B + Prostaglandin Dosing IOP and Peak and washout
OD - BID 25-30 % Peak 2 hrs Washput 1 months
49
Preservative Free antiglaucoma ?
- Ganfort - Cosopt
50
Latanosnprostene bunod naming ?
Vyzulta ( Containing Nitric Oxide ?
51
What is MOA of Vyzulta
Prostaglandin > UV outflow Nitric oxide > Relax TM
52
Common Adverse effect of Vyzulta
Conjunctival Hyperemia Eye irritate Eye Pain Instillation site pain
53
What is ROCK MOA ?
Rho kinase > Muscle contraction and cell stifness Inhibitor > Relaxation Ex Ripasudil ( Glanatec ) Netarsudil ( Rhopressa ) Once Daily
54
Netarsudil IOP Reduction and MOA?
Increase TM decrease Aqueous Decrease EVP
55
What can Rhopressa combine with ?
Rhopressa + Latanoprost = Roclatan 30-37 IOP reductio
56
Common Adverse effect of ROCK
Conjunctival hyperemia Conj Hem Cornea verticillata
57
Omidenepag isopropyl ?
Eybelis - Prostagalndin E2 agonist Increase TM and UV outflow
58
Contraindication in Eybelis
IOL / Aphakic
59
What Prostaglandin can be implant ?
Bimatorpost : 16 wks Duration IOP redcution 30 %
60
Naming Systemic Antiglaucoma
CAI : Diamox BID - QID IOP 15-20 %
61
Dosing of Diamox
10-30 kg / day Maximum 1000 mg / day
62
What is Hyperosmotic agent ?
Mannitol Dosing 2g/kg usual 50-200 g in 24 hrs period Glycerin 1-1.5 ml / kg
63
Best Anti glaucoma to use in Pregnancy and what cat ?
Brimonidine Cat B
64
Describe Alpha and Beta receptor and where are they
A1 - Ciliary muscle + > Pupil Dilate A2 - CB + > CB vaso constrict > Low Aqeous B2 - Non Pigmented of of CB > Stimulate Aqueous > Block > Lower IOP

6.Glaucoma Block (3 decks)

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