glioma Flashcards
(21 cards)
where do gliomas occur
above the tentorial line in the CNS.
are gliomas common
the most common primary brain tumor. adult predominate
which tumors occur below the tentorial line
medulloblastomas. predom in children in the cerebellum
are medullos common?q
no rare.
are gliomas serious
5 yr survival less than 3%. almost always highly invasive and chemo resistant. poor prognosis
higher grade
more aggressive
higher stage
less differentiated
proneural
more like brain, but can be aggressive
neural
more like brain, but more aggressive than proneural
classical
more unlike brain and more aggressive than pro and neural
mesenchymal
not like brain. most aggressive.
proneural analogies
oligo
neural analogies
oligo, astro, neuron
classical analogies
strong astrocyte
mesenchymal
long term astrocytic cultures
what three properties must cancer stem cells have
sustained self renewal, persistent proliferation, tumorigenic potential
hierarchical model
cells have limited potential, cancer stem cells can self-renew, only CSC have tumorigenic potential
where are cancer stem cells found in the brain
subventricular zone and subgranular zone in the hippo
what other cell types can produce tumors in the brain
oligo precursors. the are the most abundant cycling population in the brain. they have greater proliferative capacity then astrocyte precursors. they also revert to immature state when stimulated with growth factors.
what is the difference between NSC tumors and OPC
NSC have a precise anatomical location. the ventricular zone. the others do not
where are cancer stem cells found?
in the perivascular niche
