Glom path Flashcards
(23 cards)
GN
what is the difference between focal and segmental
focal refers to less than 50%of glomeruli being affected segmental refers to less than 50%of the capillary tuft being affected
GN
what does membranous refer to
thickening of glomerular membrane
GN
what is the difference between diffused and global
diffused refers to more than 50%of glomeruli being affected global refers to involvement of entire glomerular tuft
GN
what is glomerulonephritis
inflammation of the glomerulus
GN
what is glomerulosclerosis
segmental or global capillary collapse
GN
What are the symptoms of nephrotic syndrome
proteinuria hypoalbuminuria oedema hyperlipidaemia
GN
What is the common line of treatment for nephrotic syndrome
o Loop diuretics => reduction of oedema o ACEI o Underlying cause treatment o Steroids
GN
what is the pathogenesis and treatment for minimal change Gn and focal segmental glomerulosclerosis
damage to the pedicles leading to scarring steroids (may be irresponsive or recurrent)
GN
what are the risk factors for minimal change
asthma, eczema, hay fever, upper resp inf
GN
What are the risk factors for FSGN
HIV and oedema
GN
what is the damage with membranous glomerulonephritis
IgG accumulation(immune complexes) and thickening of GBM
GN
What is the treatment for membranous glomerulonephritis
steroids or cyclophosphamide
GN
what are the secondray causes of cyclophosphamide
hep B, malignancy, SLE
GN
what is the pathology of diabetes in terms of proteinuria
• Microscopic damage to the blood vessels
GN
What is pathology of Nephritic syndrome
damage that leads to haematuria
GN
What is the pathology of IgA nephropathy
IgA accumulation and damage to mesangium , usual post-streptococcal due to circulating antibody
GN
What are two common inherited condition associated with nephritic syndrome and what are the distinguishing features
Alport’ s => abnormal collagen IV, associated with deafness, X-linked thin GBM benign causes, isolated haematuria
GN
What is the pathology of Goodpasture
anti GBM antibody against collagen IV
GN
what is a common clinical presentation of Goodpasture
Acute onset nephritic syndrome High blood pressure Uremic Associated with pulmonary haemorrhage Incidence increased with smoking
GN
What is the treatment for Goodpasture or vasculitis
immunosuppression or plasmapheresis
GN
What is the antibody found in vasculitis
anti neutrophile cytoplasmic antibody
GN
what is the antibody in SLE
anti-nuclear antibody
GN
what is the microscopic difference between glomerular and haematuria and bleeding
casts and abnormal RBC in glomeruli due to squeezing of the cells on passage
