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Circulation > Glomerular Dz > Flashcards

Glomerular Dz Flashcards

(65 cards)

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1
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A

Oval fat bodies/fatty casts

Seen in Nephrotic Syndrome

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2
Q
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Fat bodies and fatty casts; appear as “maltese cross” under polarized light; seen in nephrotic syndrome

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3
Q

Describe glomerular vs extraglomerular hematuria.

A
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4
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Normular glomerulus

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5
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EM of a normal glomerulus

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6
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Mesangial proliferation (part of hypercellularity) seen in Acute Glom Dz.

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7
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* Endothelial cell proliferation (part of hypercellularity) see in acute glom. dz

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8
Q

What are the arrows pointing to?

A

Exudation: leukocyte infiltration of the glomerulus, sign of inflammation, seen in acute glomerular dz

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9
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Exudation–leukocyte (inflammatory cells) infiltration of glomerulus in acute glom dz

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10
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crescents–epithelial cell proliferation (extracapillary); part of hypercellularity seen in acute glomerular dz

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11
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Crescents—extracapillary epithelial cell proliferation; seen in acute glomerular dz

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12
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Tuft necrosis; glomerular capillary necrosis; seen in acute glomerular dz

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13
Q

What lesion distribution patterns are shown these images?

A

Left = focal, segmental (affects only part of a glomerulus, and not all glomeruli affected)

Right = focal, global (affects entire glomerulus, but only some glomeruli)

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14
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EM of an RBC squeezing through broken GBM; results in dysmorphic RBC’s (on urine sed) characteristic of glomerular hematuria

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15
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RBC’s in kidney tubules; seen in glomerular hematuria

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16
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RBC cast; sign of glomerular hematuria (pathoneumonic for Nephritic syndrome and RPGN)

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17
Q

Name the types of deposits in A, C, & D. What is B?

A
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18
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Electron-dense Immune complex deposits seen on EM

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19
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GBM Sclerosis seen on EM; seen in chronic glomerular dz.

See normal GBM on EM below

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20
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Mesangial sclerosis seen in chronic glomerular dz

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21
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Glomerularsclerosis (nodular sclerosis) seen in DM; sign of chroni**c glomerular dz

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22
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Segmental sclerosis seen in chronic glomerular dz

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23
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Segmental sclerosis and tuft adhesions seen in chronic glomerular dz

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24
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Fibrous crescent (remnant of cellular crescent); seen in chronic glomerular dz

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25
Global glomerulosclerosis; seen in *chronic* glomerular dz
26
EM of normal glomerulus
27
Membranous GM; characterized by a thickened, "tram tracks" BM; "spikes" on BM due to fixed Ag-Ab complexes on basolateral surfaces of podocyte foot processes
28
Membranous GM; characterized by a thickened, "tram tracks" BM; "spikes" on BM due to fixed Ag-Ab complexes on basolateral surfaces of podocyte foot processes
29
Membranous GM on EM; characterized by a thickened, "tram tracks" BM; "spikes" on BM due to fixed Ag-Ab complexes on basolateral surfaces of podocyte foot processes
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Membranous GN on IF; looks like "ribbon-like" GBM
31
Minimal Change Dz; see podocyte effacement on EM, but *looks normal on LM!*
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Focal Segmental Glomerular Sclerosis
33
Nodular glomerulosclerosis; seen in diabetic nephropathy
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Nodular glomerulosclerosis seen on EM; seen in DM nephropathy
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Nodular glomerulosclerosis seen in DM nephropathy
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IgA Nephrophathy; see immune complexes in mesangium
37
Globally sclerotic glomeruli seen in IgA Nephropathy
38
blue lymphocytes in area of fibrosis and atrophy; seen in IgA Nephropathy
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Fibrous crescents seen in IgA nephropathy
40
Cellular crescents (yellow arrow) and global glomerulosclerosis (blue stars) seen in IgA Nephropathy
41
IgA complexes seen on IF; IgA nephropathy
42
IgA immune complexes in mesangium on EM; seen in IgA nephropathy
43
subepithelial humps and WBC in capillary lumen seen on EM; seen in post-infections glomerulonephritis
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subepithelial humps seen on EM; indicates Post-Infectious GN
45
IgG deposits seen in IF; many polys/proliferations seen in PIGN
46
Big Ig/Complement deposits that crowd bowman's capsule; seen in Lupus nephritis
47
crescents (cell proliferation) seen in Lupus Nephritis
48
numerous electron-dense deposits seen on EM (subendothelial, subepithelial, and mesangial).
49
Full House of Ig and Complement on IF; Lupus Nephritis
50
Crescentic GN; seen RPGN (including Anti-GBM, ANCA/Pauci-immune, and immune complex dzs).
51
Linear IgG deposits seen in IF; Anti-GBM (Good Pasture's)
52
pin-pt hemorrhages, "flea-bitten" appearance of kidney; seen in Anti-GBM dz
53
What tissue is this and what dz process?
Amyloidosis in the heart
54
What tissue is this and what dz process?
Amyloidosis in the liver
55
Amyloidosis in the liver stained with Congo Red
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Amyloidosis of the glomerulus; seen with "apple green birefringence" under polarized light (congo red stain)
57
Familial amyloidotic neuropathy; TTR amyloid; a type of systemic amyloidosis
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Senile systemic amyloidosis; amyloid protein is TTR and dominant distribution is in the heart.
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Amyloid plaques seen in Alzheimers pt
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Amyloidosis seen in Islets of Langerhans of pt's with Type II DM
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Gross amyloidosis of kidney; kidney has glistening appearance
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"Sago Spleen" amyloidosis
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Lardaceous spleen amyloidosis
64
Amyloidosis of liver; first deposits are in space of Disse; with progression see encroachment on parenchyma and sinusoids, leading to pressure atrophy of hepatocytes
65
Cardiac amyloidosis; seen in systemic amyloidosis and senile amyloidosis; deposits are between myocardial cells, leads to pressure atrophy.

Circulation (10 decks)

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