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Flashcards in glossary Deck (40)
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1

Acantholysis

detachment of keratinocytes from each other due to loss of intercellular contacts. This often is associated with the cell assuming a spherical shape, i.e., a round profile in sections. This can occur in both tumors (acantholytic squamous cell carcinoma) or blistering disorders (pemphigus).

2

Acanthosis

increase in keratinocyte population of spinous layer with thickening of the epidermis; may be papillomatous or psoriasiform.

3

Adventitial dermis

the investment of fine collagen fibers and delicate blood and lymphatic vessels which surround the epidermal appendages. The papillary dermis is continuous with the adventitial dermis as the appendages penetrate through the papillary dermis and enter into the reticular dermis.

4

Apoptosis

a general process of cell death as individual cell necrosis; in skin, it often leads to a residual body containing many keratin filaments, which resemble amyloid. The residual bodies are often called "colloid bodies" (ex. lichen planus).

5

Annular

grouped (clustered) as round rings

6

Arciform

grouped (clustered) as incomplete rings, arcs

7

Ballooning Degeneration

intracellular edema with cellular swelling. This is often secondary to viral injury or nutritional deficiency (ex. herpes simplex or zoster).

8

Bulle (pl. bullae)

a circumscribed lesion, greater than 5 mm. in diameter, that is elevated and contains fluid. Also called "blister".

9

Crust

dried serum, blood, or pus on the surface. Also called a "scab".

10

Dermis

the collagenous layer between the epidermis and subcutaneous layer. See also papillary, reticular, and adventitial dermis.

11

Dyskeratosis

cell death associated with premature keratinization below the level of the stratum granulosum.

12

Erosion

A moist, circumscribed, usually depressed lesion that results from loss of all or a portion of the viable epidermis; may heal without scarring.

13

Excoriation

a traumatic erosion or ulcer which often is linear, e.g., a deep scratch.

14

Herpetiform

grouped as clusters of vesicles

15

Hypergranulosis

increase in thickness of the granular layer

16

Hyperkeratosis

increased thickness of stratum corneum, whether by normal or abnormal keratinocytes

17

Hypogranulosis

decrease in thickness of the granular layer

18

Lichenification

thickened skin, with accentuated skin markings

19

Linear

in a line, continuous or broken; may be secondary to trauma, or follow vessels or nerves. (F1) shows a poison-ivy-like lesion of contact dermatitis in a linear distribution.

20

Macule

a circumscribed, flat lesion differing in color from the surrounding skin; may be of any size.

21

Melanophage

macrophage which has ingested melanin pigment lost from the melanocytes or keratinocytes.

22

Nodule

a palpable, solid, round or ellipsoidal lesion. Usually more than 1 cm. in diameter, but may be smaller. May be deep in the dermis or subcutis, or be superficial.

23

Orthokeratosis

process of normal keratinization which leads to the production of a stratum corneum composed of anucleate squames

24

Papillary dermis

the portion of the dermis that extends from the basement membrane down to and including the superficial vascular plexus. It contains finer collagen bundles and elastin fibers than the reticular dermis.

25

Papillomatosis

increase in keratinocytes with formation of projections from the surface of the skin, i.e. papillae; typical example is a wart.

26

Papule

a small, solid, elevated lesion, less than 1 cm. in diameter, usually superficial and mostly projecting from the surface.

27

"Patch"

a large macule or large thin plaque

28

Plaque

a mesa-like elevation that occupies a relatively large surface area (more than 1 cm.). These may be formed by the coalescence of papules.

29

Poikiloderma

usually a plaque (less often a macule) that has the combination of atrophy, telangiectasia, and pigmentary alteration (hyperpigmentation and/or
Hypopigmentation ).

30

Polycyclic

grouped (clustered) as irregular rings