Gluconeogenesis Flashcards
What is the overall reaction of gluconeogenesis?
Pyruvate to glucose
How many steps are there in the gluconeogenesis reaction?
11
What is the first step ?
What catalyses the reaction?
Pyruvate –> Oxaloacetate
catalyst: pyruvate carboxylase
What is the second step ?
What catalyses the reaction?
oxaloacetate –> Phosphoenolpyruvate
catalyst: PEP carboxykinase
What is the third step ?
What catalyses the reaction?
Phosphoenolpyruvate –> 2-phosphoglycerate
catalyst: Enolase
What is the fourth step ?
What catalyses the reaction?
2-phosphoglycerate –> 3-phosphoglycerate
catalyst: phosphoglycerate mutase
What is the fifth step ?
What catalyses the reaction?
3-phosphoglycerate –> 1,3-biphosphoglycerate
catalyst: Phosphoglycerate kinase
What is the sixth step ?
What catalyses the reaction?
1,3-biphosphoglycerate –> glyceraldehyde-3-phosphate
catalyse: glyceraldehyde phosphate dehydrogenase
What is the seventh step ?
What catalyses the reaction?
glyceraldehyde-3-phosphate (GAP) –> dihydroxyacetate phosphate (DHAP)
Catalyst: triose phosphate isomerase
this is a reversable reaction
What is the eight step ?
What catalyses the reaction?
Dihydroxyacetate phosphate –> Fructose-1,6-biphosphate
catalyst: aldolase
What is the ninth step ?
What catalyses the reaction?
Fructose-1,6-biphosphate –> Fructose-6-phosphate
catalyst: fructose 1,6-biphosphatase
What is the tenth step ?
What catalyses the reaction?
fructose-6-phosphate –> Glucose-6-phosphate
catalyst: phosphohexose isomerase
What is the eleventh step ?
What catalyses the reaction?
glucose-6-phosphate –> glucose
catalyst: glucose-6-phosphate
