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solemne 2 fco > Glucopeptidicos > Flashcards

Glucopeptidicos Flashcards

1
Q

Características

Espectro

A

Bactericidas

Espectro: Gram + y anaerobios

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2
Q

Antibióticos glucopeptidicos

A

Vancomicina

Teicoplaina

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3
Q

Usos

A

Gram + y anaerobios resistentes

  • colitis pseudomembranosa
  • inf urinaria, piel, o asociada al catéter
  • en pcte con alergia a penicilinas y cefalosporinas
  • endocarditis
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4
Q

Vía de administración

A

Vancomicina: oral y Ev
Teicoplanina: IM

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5
Q

Mecanismo

A

Inhibe síntesis de peptidoglicano

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6
Q

Mecanismo

A

Inhibe síntesis de peptidoglicano

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7
Q

Mecanismo resistencia

A

Modifica secuencia del residuo de alanina-lactato lo que evita la unión del glucopeptidico la síntesis de peptidoglicano

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8
Q

Mecanismo resistencia

A

Modifica secuencia del residuo de alanina-lactato lo que evita la unión del glucopeptidico la síntesis de peptidoglicano

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9
Q

Resistencia

Vida 1/2

A

Vancomicina > teicoplanina

Vanco 4-8 hrs; teico 40-70 hrs

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10
Q

Liposulubilidad y penetración

A

Teico> vanco

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11
Q

Excreción

A

Renal

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12
Q

Rams vanco

A 
Fiebre
Flebitis local
Ototoxicidad
Nefrotoxicidad
Síndrome hombre rojo o cuello rojo 🔴 (por liberación histamina) puede ir acompañado con hipotensión
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13
Q

Rams teico

A

Alteración auditiva, cutánea, hematológica.

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14
Q

Contraindicaciones

A

Insuficiencia renal

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solemne 2 fco (6 decks)

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