Glycolysis Flashcards Preview

BCH 351 > Glycolysis > Flashcards

Flashcards in Glycolysis Deck (10):
1

First step in Glycolysis

Glucose -> Glucose-6-phosphate

Enzyme: hexokinase (transferase)

-reaction is metabollically irreversible

-the product of the reaction allosterically inhibits hexokinase I, II, and III. This is an example of feedback inhibition

-reaction requires Mg2+, as a cofactor for ATP

A image thumb
2

Second Step in Glycolysis

Enzyme: Glucose-6-phosphate isomerase (isomerase)

-subject to regulation through concentration Near Equilibrium reaction

A image thumb
3

Third Step in Glycolysis

Enzyme: phosphofructokinase-1 (PFK-1)

-metabollically irreversible

-first commited step of glycosis since other substrates may enter glycolysis in a way that by-passes reactions one and two. Subject to intense regulation as a result

A image thumb
4

4th step in glycolysis

Enzyme: 1,6-bisphosphate aldolase

-Near Equilibrium reaction

-produces glyceraldehyde and dihydroxyacetone phosphate (metabollic deadend)

A image thumb
5

5th step in Glycolysis

Enzyme: triose phosphate isomerase (isomerase)

-near equilibrium reaction that is driven by the principle of mass action

-

A image thumb
6

6th step in glycolysis

Enzyme: Glyceraldehyde-3-phosphate dehyrogenase (oxidoreductase)

NAD+ electron acceptor

A image thumb
7

7th step in glycolysis

Enzyme:Phosphoglycerate kinase

 

-near equilibrium substrate-level phosphorylation

A image thumb
8

8th step of glycolysis

Enzyme: Phosphoglycerate Mutase (Isomerase)

-near equilibrium reaction

A image thumb
9

9th step of glycolysis

Enzyme: Enolase

-Magnesium is required to facilitate the forward reaction. Mg2+ stabilizes the terminal carboxylate group and catalyzes the dehydration reaction

A image thumb
10

10th Step of Glycolysis

-substrate level phosphorylation

-reaction is metabollically irreversible

-Pyruvate Kinase (transferase)

A image thumb