Flashcards in Glycolysis Deck (11):
Net ATP from Aerobic Glycolysis using Malate aspartate shuttle
1 NADH = 2.5 ATPs
4 ATP (substrate level phosphorylation – 2 ATP (investment at hexokinase & PFK-1) + (2NADH x 2.5)
Net ATP from Aerobic Glycolysis using Glycerophosphate Shuttle
1 NADH = 1.5 ATPs
4 ATP (substrate level phosphorylation – 2 ATP (investment at hexokinase & PFK-1) + (2NADH x 1.5)
Net ATP from Anaerobic Glycolysis
Most potent activator of PFK-1
(product of PFK-2)
Conversion of Pyruvate to Lactate during Anaerobic glycolysis uses what enzyme?
Conversion of Pyruvate to Acetyl CoA in Kreb's cycle uses what enzyme?
Conversion of Pyruvate to Oxaloacetate in Gluconeogenesis uses what enzyme?
(Addition of Carbon)
Most common cause of congenital lactic acidosis
Pyruvate dehydrogenase deficiency
Most common enzyme defect in glycolysis
Pyruvate kinase deficiency
(3) Irreversible steps of Glycolysis
Step 1. Glucose phosphorylation
Step 3. Fructose-6-Phosphate phosphorylation
Step 10. Pyruvate formation