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[Topnotch Biochemistry 2017] > Glycolysis > Flashcards

Flashcards in Glycolysis Deck (11):
1

Net ATP from Aerobic Glycolysis using Malate aspartate shuttle

7 ATPs

1 NADH = 2.5 ATPs

4 ATP (substrate level phosphorylation – 2 ATP (investment at hexokinase & PFK-1) + (2NADH x 2.5)

2

Net ATP from Aerobic Glycolysis using Glycerophosphate Shuttle

5 ATPs

1 NADH = 1.5 ATPs

4 ATP (substrate level phosphorylation – 2 ATP (investment at hexokinase & PFK-1) + (2NADH x 1.5)

3

Net ATP from Anaerobic Glycolysis

2 ATPs

4

Most potent activator of PFK-1

Fructose-2,6-biphosphate

(product of PFK-2)

5

Conversion of Pyruvate to Lactate during Anaerobic glycolysis uses what enzyme?

Lactate dehydrogenase

6

Conversion of Pyruvate to Acetyl CoA in Kreb's cycle uses what enzyme?

Pyruvate dehydrogenase

7

Conversion of Pyruvate to Oxaloacetate in Gluconeogenesis uses what enzyme?

Pyruvate Carboxylase

(Addition of Carbon)

8

Most common cause of congenital lactic acidosis

Pyruvate dehydrogenase deficiency

9

Most common enzyme defect in glycolysis

Pyruvate kinase deficiency

10

(3) Irreversible steps of Glycolysis

Step 1. Glucose phosphorylation
Step 3. Fructose-6-Phosphate phosphorylation
Step 10. Pyruvate formation

11

(2) Energy/ATP investment steps

Step 1. Glucose phosphorylation
Step 3. Fructose-6-Phosphate phosphorylation