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PCOG LEC > Glycosides > Flashcards

Glycosides Flashcards

1
Q

They yield one or more sugars among the product of hydrolysis

A

glycosides

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2
Q

Glycosides are molecules which aa sugar group is _______ through its _________ to another group via __________

A

Bonded
Anomeric Carbon
Glycosidic Bond

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3
Q

Enumerate the examples of glycoside sources and where they are from

A

Digitoxin - Digitalis
Salicin - Salix
Prunasin - Prunus

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4
Q

Formed by replacing “ose” suffix of the parent sugar with “oside”

A

Systematic Name

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5
Q

The most frequently occurring sugar

A

Beta - D - Glucose

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6
Q

What is the difference between glucoside and Glycoside

A

Glucoside - Sugar formed is glucose
Glycoside - Sugar other than glucose is produced

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7
Q

What are the non-sugar components of glycosides

What is the sugar component

A

Aglycone
Aglycon or Genin

Glycone

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8
Q

Importance of glucose

A

Involved in:
Regulatory , Protective, Sanitary

Therapeutic Agent

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9
Q

Where does Glycosides form (Occurance)

A

Fruits
Seeds
Barks
Leaves
Animals (rare)

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10
Q

What are the classifications of Glycosides

A

O-glycosides - Phenol or OH group
N-glycoside - N of Anino Acid group
S-Glycoside - S of Thiol group
C-Glycoside - C atom

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11
Q

Related to steroids, CPPP nucleus

A

Cardiac Glycosides

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12
Q

Test for Cardiac Glycosides

A

Leibermann-Burchard Test - Cardenolides/ Bufadienolides

Kedde Reaction - lactone ring

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13
Q

Ability to increase force of systolic contraction

A

Inotropic Effect

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14
Q

DIGITALIS PURPUREA includes ______

A

Digitoxin
Gitaloxin
Gitoxin

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15
Q

DIGITALIS LANATA includes

A

Digoxin
Desacetyl lanatoside (deslanoside)

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16
Q

It has a polar structure because of OH group and is more commonly used cardiac glycoside

A

Digoxin

17
Q

Digoxin uses pigeon for bioassay and is easily eliminated (T/F)

A

True

18
Q

Digitoxin is Lipophilic and has a shorter half-life (T/F)

A

False (Longer HL)

19
Q

Digitoxin is now used to manage ______

A

Arrhythmia, atrial fibrillations

20
Q

Examples of Cardiac Glycosides and where to get them

A

Convallaria - Convallaria majalis
Apocynum - Apocynum cannabinum
Adonis - Adonis vernalis
Cactus Grandiflorus - Selenicereus grandiflorus
Black Hellebore - Helleborus niger
Storophanthus - S. Kobe and S. hispidus
Squill - Urginea Maritima
Adelfa - Nerium oleander

PCOG LEC (21 decks)

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