GN treatment Flashcards Preview

Therapeutics Test 2 > GN treatment > Flashcards

Flashcards in GN treatment Deck (18):
1

what are two specific therapy categories gor glomerulonephritis?

1. immunosuppressants
2. plasmapheresis

2

what is plasmapheresis?

spinning out protein layer in blood, removing antibodies that cause glomerulonephritis

3

what makes more antibodies that can potentially cause GN when in circulation?

B cells

4

what are 4 immunosuppressives uses in GN treatment?

1. corticosteroids
2. cyclosporine
3. mycophenolate/ azathioprine
4. cyclophosphamide

5

why are corticosteroids an effective treatment

inhibit proinflammatory cytokines

6

what lymphocyte is responsible for proliferation of T-cells?

IL-2

7

what does cyclosporine inhibit in GN tx

IL-2 production
(and other lymphokines)

8

what does mycophenolate inhibit in GN tx

inhibits guanine synthesis

9

mycophenolates MOA is more specific for inhibiting what?
why is this?

T-cell specific (some B cells)
platelets, RBC's... use salvage pathways, T-cells don't use salvage pathways (de novo only)

10

what are guanine nucleotides imperative for?

RNA and DNA synthesis

11

what does azathioprine inhibit?

cellular purine synthesis

12

why is mycophenolate preferred to azathioprine?

azathioprine inhibits many cells in blood, causing many side effects

13

azathioprine is converted to what?

6-mercaptapurine

14

what immunosuppressant's inhibit guanine synthesis

mycophenolate (guanine only) and azathioprine (all purines including guanine)

15

what is cyclophosphamides MOA?

inhibits DNA crosslinking, stopping cell division

16

at what doses is cyclophosphamide used as an immunosuppressant?

low oral doses

17

what inhibits a wide variety of B and T cells

azathioprine

18

what cells are affected by cyclophosphamide the most?

fastest dividing cells (like immune cells)