Gout

Question 1

Colchicine MOA

Answer 1

• binds to tubulin, decreases microtubular polymerization
• decrease formation of LTB4
• inhibits leukocyte and granulocyte migration

Question 2

Colchicine Adverse effects

Answer 2

Diarrhea, GI pain, peripheral neuropathy , hematuria, alopecia

Question 3

Allopurionol MOA

Answer 3

Inhibit xanthine oxidase and decrease purine metabolism and therefore iron acid

Question 4

Allopurinol adverse effect

Answer 4

Peripheral neuropathy, stone formations, rash, vasculitis

Question 5

Febuxostat MOA

Answer 5

Non purine selective inhibitor

Inhibit 6MP

Question 6

Febuxostat adverse effect

Answer 6

GI upset, arthralgia, HA, rash

AVOID: if patient on Theophylline, Azathioprine or 6MP

Question 7

Probenecid MOA

Answer 7

Inhibit proximal tubule reabsorption or urate

Inhibit secretion of acidic drugs

Question 8

Probenecid Adverse effect

Answer 8

High excretion of urate –> urate crystals in kidney

Aspirin antagonizes the uricosuric action and interferes with clearance of methotrexate

Question 9

Sulfinpyrazone MOA

Answer 9

Inhibit proximal tubule re absorption of urate(like Probenecid)

Inhibit secretion of acidic drugs

Inhibit platelet aggregation

Question 10

Sulfinpyrazone Adverse effect

Answer 10

GI distress, rash, NEPHROTIC SYNDROME