Immunosuppresant

Question 1

Cyclosporine MOA

Answer 1

Binds to Cyclophillin leading to DECREASE CALCINEURIN

DECREASE IL-2, IL-3, IFN gamma

Question 2

Cyclosporine adverse effects

Answer 2

NEPHROTOXICITY, gingival hyperplasia, HTN

Question 3

Tacrolimus MOA

Answer 3

Macrolide antibiotic and binds to immuno Phillip

INHIBITS CALCINEURIN = DEC IL-2

Question 4

Tacrolimus adverse effects

Answer 4

Peripheral neuropathy, HTN, pleural effusion, hyperglycemia

Question 5

Azathioprine MOA

Answer 5

Converterd to 6-MP

Question 6

Azathioprine adverse effects

Answer 6

Leukopenia, thrombocytopenia and hepatotoxicity

Drug reaction with Allopurinol

Question 7

Muromonab MOA

Answer 7

Monoclonal AB to CD 3

Question 8

Muromonab adverse effect

Answer 8

Must be administered with Methylprednisone BEFORE to prevent cytokines release syndrome

Question 9

Sirolimus (Rapamycin) MOA

Answer 9

mTOR inhibitor

Inhibits T cell proliferation

Question 10

Sirolimus (Rapamycin) adverse effects

Answer 10

MYELOSUPPRESION

Question 11

Mycophenolate (MMF) MOA

Answer 11

Inhibits de novo synthesis of purines

Question 12

Mycophenolate (MMF) adverse effects

Answer 12

HTN, peripheral edema and GI distress

Question 13

Thalomide MOA

Answer 13

Inhibit IL-2, TNF alpha

Question 14

Thalidomide adverse effects

Answer 14

INHIBITS ANGIOGENESIS

TERATOGENIC- fetal limbs don’t grow