GPCR Flashcards
Dales principle
neuron has only one neurotransmitter
Co-transmitters
2+ released from one nerve terminal
3 criteria for neurotransmitter
synthesis and storage in presynaptic neuron
must be release by axon terminal
must produce postsynaptic change
ionotropic receptors
component of transmitter-gated ion channels, in or out of neuron
metabotropic receptors
PM, indirect influences on ion, connected to metabolic processes initiated during bindings
structure of G-protein coupled receptors
polypeptide with 7-membrane spanning alpha-helices
GPCR activate
cascade of enzyme-catalyzed reactions
GPCR form
second messengers
Second messengers
intracellular chemical messenger molecules that open or close ion channels in PSM
cyclic adenosine monophosphate (cAMP)
common second messenger derived from ATP
G-protein cascades
alpha or beta-gamma subunits dissociates and activates membrane bound enzyme
Alpha subunits contains
GTPase
G-protein subunits
alpha, beta-gamma
Different g-proteins
stimulate or inhibit adenylate cyclase
G-protein subunits is activated by
GDP to GTP exchange
G-protein activates
adenylate cyclase
Adenylate cyclase activates
cAMP
cAMP activated
ion channels via phosphorylation
acetylecholine
basic schema of classical neurotransmitter signaling is typified
inotropic receptor typified by
nicotinic acetylcholine
complete pentameric structure forms
ion pore and ligand binding sites
2 molecules of Act required to
open channel portion of inotropic receptors
(-) charged amino acids at
pore loop initially attract ions
structure/function of metatropic receptor is typified by
Muscarinic Ach receptors
