Grant Flashcards
(20 cards)
What are opiate antagonists?
Class of drugs produced by opium, found in poppies
What is the effect of opiate antagonists on the body?
They reduce the effects of opiates by blocking receptors
What neurotransmitter’s activity is inhibited when opioid receptors are actuated?
GABA
What happens to dopamine levels when GABA is inhibited?
Dopamine levels increase, leading to a sense of euphoria
What is the primary aim of the research discussed?
To investigate the factors that predict the effectiveness of opiate antagonists in treating gambling disorder
What hypothesis is proposed regarding individuals with a family history of alcoholism?
They would have stronger urges and greater response to euphoria from alcohol
What is the placebo effect?
A phenomenon where participants respond positively to treatment without the active drug
What is a meta-analysis?
A statistical analysis that combines results from multiple studies
How many participants were involved in the study?
284 participants
What criteria were used to diagnose participants in the study?
DSM-IV and scored five or more on the South Oaks Gambling Screen (SOGS)
What was the treatment duration for participants in the trial?
18 weeks
What were the dosages of nalmefene used in the study?
25 mg, 50 mg, or 100 mg
What method was used to assess the severity of gambling disorder symptoms?
Modified version of the Yale-Brown Obsessive-Compulsive Scale
What constitutes a positive response to treatment in the study?
A decrease of more than 35% in gambling disorder symptoms
What were the strengths of the study?
Double-blind design, representative sample, diverse participant backgrounds
What were some weaknesses of the study?
Self-reported family history of alcoholism, lack of follow-up assessment
What age range did the participants fall into?
Aged 19-72
What types of interviews were conducted for data gathering?
Structured and semi-structured interviews
What is the significance of the placebo group in clinical trials?
It helps to assess the true effectiveness of the treatment being tested
Fill in the blank: Opiate antagonists can prevent urges of _______.
gambling
