Guillain-Barre

Question 1

What is GB syndrome

Answer 1

Autoimmune acute inflammatory demyelinating polydadiculopathy only effecting CNS

Question 2

Causes of GB syndrome

Answer 2

40% by Campylobacter jejuni, followed by CMV

Question 3

Symptoms of GB syndrome

Answer 3

Symmetrical rapid onset of lower limb weakness, loss of tendon reflexes and autonomic dysfunction. Various sensory signs

Question 4

Time course of GB syndrome

Answer 4

Spreads upwards over hours-days, symptoms progress for 2 weeks, plateau for 2-4 weeks then improve

Question 5

Outcomes of GB syndrome

Answer 5

Bulbar weakness and respiratory failure in 20-30%.
5% die in acute phase
10% will have incomplete recovery

Question 6

Supportive management of GB syndrome

Answer 6

Ventilation, measures to reduce VTE and CV support

Question 7

Medical management of GB syndrome

Answer 7

Immunoglobulins (IgG) given in first 2 weeks, plasmaphoresis used within 4 weeks