Gynecology Flashcards

(68 cards)

1
Q

What HPV strains cause cancer

A

16, 18, 30s

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2
Q

Risk Factors for Cervical cancer

A

HPV, Sex, STDs, Smoking

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3
Q

Cervical CA
Presentation
Dx, Tx

A
Asx Screening, post-coital bleeding 
Dx: Pap-smear, staging 
Tx: ASCUS-HPV DNA 
Ectocarcinoma-Local Ablation 
Endocarcinoma-Cone biopsy
Stage IIa or less-resection
Stage IIb or greater-debulking +/- chemo/rad
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4
Q

Stage I Cervical Cancer

A

contained in the cervix

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5
Q

Stage II Cervical Cancer

A

IIa- upper 2/3 of the vagina

IIb- involvement of the cardinal ligament

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6
Q

Stage III Cervical Cancer

A

IIIa- lower 1/3 of vagina

IIIb- Pelvic side wall

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7
Q

Stage IV Cervical Cancer

A

IVa- Adjacent organs

IVb- Distant mets

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8
Q

Endometrial Cancer Patient presentation/patient history

A
unopposed estrogen exposure or prolonged estrogen exposure 
Anovulation
Age
Nulliparity
Obese 
Early Menarche/late Menopause 
HRT/SERM for breast CA
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9
Q

Endometrial CA warning sign

A

postmenopausal bleeding

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10
Q

Postmenopausal Bleeding

Dx, Tx

A

Dx: Bx
Tx: Hyperplasia-progesterone
CA:TAHBSO
+/- Chemo/rad (Paclitaxel, cisplatin, doxorubicin)

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11
Q

Ovarian Cancer-Germ Cells

A

Dysgerminoma, endodermal sinus, teratoma, choriocarcinoma

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12
Q

Dysgerminoma Tumor marker

A

LDH

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13
Q

Endodermal Sinus Tumor marker

A

AFP

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14
Q

Choriocarcinoma Tumor marker

A

B-HCG

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15
Q

Germ Cell tumors
Presentation
Dx, Tx

A

Teenage girls, adnexal mass, weight gain, usually stage I
Dx: Transvaginal ultrasound
Tx: Unilateral salpingoophrectomy

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16
Q

Ovarian Cancer- epithelial cell

A

Cystadenocarcinoma-Serous, Mucinous, Endometroid

Brenners

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17
Q

Epithelial Cell Tumors, Tumor Markers

A

CA-125

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18
Q

Epithelial Cell Tumors
Presentation
Dx, Tx

A
Postmenopausal woman nulliparous-there could be renal failure, SBO, Ascites 
Dx: Transvaginal ultrasound
CT scan for staging 
Tx: TAHBSO 
Paclitaxel
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19
Q

BRCA1-HNPCC

Ovarian cancer screening

A

Risk factor for epithelial cancer -

screen with ultrasound and CA-125

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20
Q

Granulosa-Theca Cell Tumor

Presentation

A

Secrete Estrogen

Dx: Transvaginal Ultrasound

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21
Q

Sertoli-Leydig Cell Tumor

Presentation

A

Secretes Testosterone

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22
Q

Complete Hydatidiform Mole
Presentation
Dx, Tx

A

All sperm, Good fertilization with a bad egg
Presentation: Size-Date discrepancy
>100k B-Hcg
Hyperthyroidism
Hyperemesis gravidarum
Grape-like mass, adenexal mass
Dx: Transvaginal ultrasound-snow storm appearance
Tx: Suction curretage
afterwards-OCP for 12 months and monitor B-HCG

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23
Q

Incomplete Mole
Presentation
Dx, Tx

A

Fetal parts found
Egg Sperm Sperm fertilization
presentation, Dx, Tx and follow up are the same as complete mole

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24
Q

Choriocarcinoma
Presentation
Dx, Tx

A
Malignant, gestational contents 
Pt: high levels of B-HCG
can occur after a miscarriage, molar or normal pregnancy 
Dx: Transvaginal ultrasound
Bx with curretage 
Stage with CT 
Tx: Surgical-TAHBSO, Debulking
Medical-Methotrexate, Actinomycin D, Cyclophosphamide
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25
Post-partum Hemorrhage Presentation Tx
``` 500c-after vaginal birth 1000cc-after c-section non-surgical: uterine massage oxytocin balloon tamponade ```
26
Teratoma Presentation Dx, Tx
``` usually benign young female in her teens Asx, Weight gain Dx: Ultrasound=enormous mass Tx: Cystectomy ```
27
Adenexal mass Simple Cyst | Presentation
Small, Consistent, unilocular, anechoic, homogenous <3cm=watch and wait <10cm=repeat imaging
28
Adenexal mass Complex Cysts | Presentation
Big, Septations, Loculated, Multi-Echoic heterogenous >10cm=remove
29
Endometriosis Presentation Dx, Tx
``` Pt: Dysmenorrhea, Dyspareunia, Infertility Dx: U/S=cyst (endometrioma) OCP trial=endometriosis Dx Lap with laser ablation Tx: NSAIDs (pelvic Pain) OCPs ```
30
Ectopic Pregnancy Presentation Dx, Tx
``` RF-stricture or PID Pt: Amenorrhea/spotting Abdominal pain UPT (+) Dx: UPT(+) B-HCG >2000 Empty uterus on US Tx: Salpingosotmy if no ruputre salpingectomy if ruptured Methotrexate +/- leucovorin ```
31
When do you use methotrexate +/- leucovorin
B-HCG <5000 Gestational size <3 cm No fetal heart tones not using folate
32
Tubo-Ovarian Abscess Presentation Dx, Tx
``` Abdominal or pelvic pain no other cause + 1 of 3 1. CMT 2. ADT 3. UT possible fever and leukocytosis white cells on a wet prep Dx: U/S abscess Tx: Inpatient IV 1. Cefoxitin+Doxy+MTZ 2. Clindamycin+gentamicin ```
33
Stress Incontinence Presentation Dx, Tx
Sneeze and pee No urge or nocturnal symptoms Tx: kegel Surgery
34
Hypertonic, Overactive Bladder Presentation Dx, Tx
``` (+) Urge and nocturnal symptoms Leaking with contractions Dx: Physical is normal U/A normal decreased cystometry Tx: Oxybutynin ```
35
Irritative Bladder Presentation Dx, Tx
``` Caused by inflammation, stones, CA, UTI Frequency, urgency, Dysuria (+) urge no nocturnal symptoms Dx: U/A=WBCs Tx: UTI=ABx Stones=Imaging CA=imaging ```
36
Fistula Presentation Dx, Tx
``` Continuous leak normal function Dx: Physical=fistula Tampon Test Tx: Fistulotomy ```
37
Causes of vaginal bleeding in the premenarchal age
Foreign body sexual abuse precocious puberty
38
Causes of vaginal bleeding in the reproductive age
Pregnancy, Anatomy, AUB, Cervical CA
39
Causes of vaginal bleeding in the postmenopausal age
vaginal atrophy endometrial CA HRT
40
Vulvovaginitis-Candida Presentation Dx, Tx
``` DM, Steroids, Abx Thick white discharge adherent to the vaginal wall no odor Wet prep-hyphae Tx= Topical antifungal oral fluconazole ```
41
Vulvovaginitis-Bacterial Gardenerella Presentation Dx, Tx
Copious thin white discharge Fishy odor wet prep-clue cells Tx: MTZ
42
Vulvovaginitis-Trichomonas Presentation Dx, Tx
``` Yellow-green discharge Frothy Strawberry Cervix Wet-prep: Flagella, motile Tx: MTZ, treat both partners ```
43
Cervicitis Presentation Dx, Tx
``` Inflammation of the cervix usually caused by NG/CT (+) CMT, discharge, no PID NG/CT PCR gonorrhea- GNR diplococci Chla-NOS many WBCs Tx=NG=Ceftriaxone CT=Doxyxycline/azithromycin ```
44
PID Presentation Dx, Tx
1. Pelvic/abdominal pain 2.no other cause 1 of 3: 1.CMT 2. ADT 3. UT Dx: Transvaginal ultrasound Tx: inpatient- cefoxitin+Doxy Clindamycin+Gentamycin Outpatient- Ceftriaxone+doxy+MTZ
45
Threatened abortion Features
No passage of contents closed cervical os live baby on U/S
46
Inevitable abortion features
No passage of contents Open cervical os Dead baby on U/S
47
Incomplete abortion features
Passage of clots or fetal parts Open cervical os Retained fetal parts on U/S
48
Complete abortion features
passage of contents Closed cervical os Nothing on U/S
49
Causes of vaginal bleeding | PALM COEIN
Polyps Adenomyosis Leiomyomas Malignancy ``` Caogulopathy Ovarian Dysfunction Endometrium Iatrogenic=IUD Not yet Classified ```
50
Fibroids (leiomyoma) Presentation Dx, Tx
``` benign growths that are responsive to estrogen Pt: Asx nodularity Anemia/bleeding Pain, infertility Dx: Transvaginal ultrasound Tx: OCPs=IUD if kids=myomectomy no kids=TAH ```
51
PCOS Presentation Dx, Tx
``` Pt: Fat and hairy Metabolic Syndromes (HTN,DM,HLD) Menometorrhagia Infertility Dx: 1. Anovulation AND 2.Biochemical (DHEAS, increased Testosterone) OR 3. Follicles on U/S Tx: Metformin OCPs Clomiphene Spironolactone ```
52
Puberty Ages
Tits (breasts) 8 Pits (axillary) 9 Mits (growth spurt) 10 Lips (menarche) 11
53
What defines precocious puberty
No menarche by 15 | No secondary sex characteristics by 13
54
Craniopharyngioma/Kallmans Presentation Dx, Tx
``` either a problem with hypothalamus or the anterior pituitary - no FSH/LH Pt: no secondary sex characteristics there are uterus and tubes Dx: decreased FSH/LH MRI differentiates the two diseases Tx: give estrogen and progesterone possible resection if there is a tumor ```
55
Mullerian Agenesis Presentation Dx, Tx
``` (x,x) karyotype Pt: Secondary sexual characteristics with female genitalia no uterus or tubes Dx: Karyotype Normal testosterone, FSH, LH Tx: Elevate the vagina ```
56
Androgen Insensitivity syndrome Presentation Dx, Tx
``` (x,y) resistance to testosterone Pt: secondary sexual characteristics external sexual characteristics no uterus or tubes Dx: Karyotype Increased testosterone, normal FSH, LH Tx: elevate vagina after puberty-orchiectomy ```
57
Turner Syndrome Presentation Dx, Tx
Webbed neck, Broad spaced nipples, Shield like chest, Coarctation, Bicuspid Aortic Valve secondary sexual characteristics uterus and female genitalia present Dx: Karyotype (x,o) increased FSH and LH U/S-Streak ovaries Tx: Estrogen and progesterone F/U echocardiogram
58
Causes of secondary amenorrhea
``` Pregnancy MC Hypothyroidism 2nd MC Prolactin Medications HPO Axis ```
59
Secondary Amenorrhea Diagnostic Tests
Progesterone Challenge Estrogen & Progesterone FSH & LH MRI
60
Progesterone challenge positive
Bleeding indicated PCOS
61
Estrogen and progesterone positive (bleeding)
Check FSH & LH Check FSH/LH ratio increased-ovarian problem normal/decreased-brain do MRI
62
Hostile Mucous indications
(-) Fern sign (-) Sperm < 6cm smush test
63
Normal Mucous indications
(+) fern, sperm | > 6cm Smush
64
PCOS Presentation Dx, Tx
``` Hirsuitism Increased testosterone Normal DHEAS Bilateral Ovaries LH/FSH= >3:1 follicles on US Tx: Exercise and weight loss metformin OCPs Clomiphene ```
65
Sertoli-Leydig Tumor Presentation Dx, Tx
``` Virilization Very High levels testosterone DHEAS-Normal Unilateral Ovary US shows tumor Tx: Resection ```
66
Adrenal Tumor Presentation Dx, Tx
``` Virilization Testosterone Normal DHEAS very increased Unilateral Adrenal CT/MRI Adrenal Vein Sampling Tx: Resection Make sure to do the adrenal vein sampling before surgery ```
67
CAH Presentation Dx, Tx
``` Hirsuitism Testosterone Normal DHEAS elevated Bilateral Adrenals CT/MRI 17-OH progesterone in the urine Tx: Cortisol fludrocortisone ```
68
When should you perform a DEXA scan
``` All get DEXA @ 65 60 if a smoker Bisphosphonates Give vitD and calcium if VitD deficient-50ku promote exercise ```