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Flashcards in haem I don't know Deck (31):
1

Treatment of myelofibrosis

only cure is an allogenic stem cell transplant

if symptomatic, give chemotherapy to shrink the spleen and prevent marrow angiogenesis- ruxolitnib or hydroxycarbamide

2

mechanism of myelofibrosis

myeloproliferative disorder- JAK 2 mutation

hyperplasia of megakaryocytes, leading to platelet derived growth factor, stimulating fibroblasts

3

%myelofibrosis that transforms to leukaemia

15%

4

action aspirin

acts on COX 1 preventing thromboxane a2

affects aggregation for full lifespan of platelet

5

treatment of iron deficiency

1. oral iron suppliment
2. iv iron
3. red cell transfusion only if symptomatic at rest

6

how to measure iron levels in blood

serum ferratin

7

blood film- Iron deficience anaemia

microcytosis, hypochromic,

8

neuro complication of b12 deficiency

Subacute combined degeneration of spinal cord, treat with b12 and folate suppliments

9

names of alpha thatassaemia diseases

1 missing- trait
3 missing- HbH disease (low mcv and mch)
4 missing- Hb barts hydrops fetalis

10

treatment sickle crisis

analgesia
antihistamine
hydration
antibiotics

if acute chest- give oxygen and spirometry

11

sicke cell aplastic crisis

cessation of RBC production due to parovirus B19

blood film has no reticulocytes

12

causes of intravascular haemolysis

ABO incompatibility
G6PD
Black water fever

13

pathophysiology of anaemia of chronic disease

increased hepcidin
increased cytokies TNF and IL1 and 6
shortened RBC lifespan
blunted EPO

14

where does cold and warm haemolysis occur

warm- exravascular

cold- intravascular in peripheries

15

Haemoglobin tyes present in haemoglobin A1

a2, b2

16

Haemoglobin tyes present in haemoglobin A2

a2, delta2

17

Haemoglobin tyes present in haemoglobin F

a2 and gamma 2

18

HbA1C

A2, b2, glucose

19

genetic abnormality in AML

oncogenic mutations impeding differentiation

20

Blood count resut in CML

Inc wbc
Inc eosin
inc basophil

21

blood film result in AML

auer rods
>30% myeloblasts

22

cells present in hodgekins lymphoma

reed sternberg cells

23

What is R-CHOP

Rituximab

Cyclophosphamide
doxorubicin Hydrochloride
Oncovin (now called vincristine
Prednisolone

24

when is r-chop used

treatment of non-hodgekins lymphoma

25

rituximab mechanism of action

attacks cd20- present on b cells

26

protein found in myeloma

bence jones protein (light chain found in urine)

27

backache and raised ESR

myeloma

28

The oxygen-haemoglobin dissociation curve is shifted to the right in which of the following scenarios?

Hypothermia

Respiratory alkalosis

Low altitude

Decreased 2,3-DPG in transfused red cells

Chronic iron deficiency anaemia

iron deficiency anaemia

right shifting-

CADET face RIGHT

C O2
A cidosis
2,3-DPG
E xercise
T emperature

29

what is gilbert's syndrome

Gilbert’s syndrome is a genetic disorder that's hereditary (it runs in families). People with the syndrome have a faulty gene which causes the liver to have problems removing bilirubin from the blood.

30

what is factor 3 also known as

tissue factor

31

what is Bernard soulier syndrome

Bernard-Soulier syndrome is an autosomal recessive bleeding disorder caused by a deficiency in the platelet glycoprotein complex Ib-IX-V, which would normally bind to von Willebrand factor (vWF) to allow platelet adherence. As vWF cannot bind, platelet adhesion is impaired and patients present with usual symptoms of coagulopathies like abnormal bleeding and bruising.