What are common causes of tiredness?
Anaemia (also includes bleeding)
What can cause iron deficiency alongside B12 deficiency?
Investigation would be upper GI endoscopy
What are the causes of marked splenomegaly?
Low grade lymphoma (splenic enlargement would probably be a bone marrow lymphoma crossover)
Chronic leukaemias (CML, CLL)
Portal hypertension / liver disease
Infiltration from sarcoidosis, other malignancies
Infections eg chronic malaria, visceral Leishmaniasis
What are the genetic markers for myeloproliferative disorders?
What are causes of lymphocytosis?
Viral infection (e.g. EBV, CMV, HIV)
Other infections – TB, brucellosis, syphilis
Acute lymphoblastic leukaemia
Chronic lymphocytic leukaemia