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Flashcards in Haematological malignancy in practice Deck (5):
1

What are common causes of tiredness?

Anaemia (also includes bleeding)

Depression

Hypothyroidism

Malignancy)

2

What can cause iron deficiency alongside B12 deficiency?

Gastric cancer

 

Investigation would be upper GI endoscopy 

3

What are the causes of marked splenomegaly?

—Low grade lymphoma (splenic enlargement would probably be a bone marrow lymphoma crossover)

—Chronic leukaemias (CML, CLL)

—Myeloproliferative disorders

—Portal hypertension / liver disease

—Infiltration from sarcoidosis, other malignancies

—Infections eg chronic malaria, visceral Leishmaniasis

4

What are the genetic markers for myeloproliferative disorders?

JAK2

CALR

MPL

5

What are causes of lymphocytosis?

—Viral infection (e.g. EBV, CMV, HIV)

—Other infections – TB, brucellosis, syphilis

—Vasculitis

—Acute lymphoblastic leukaemia

—Chronic lymphocytic leukaemia

—Lymphoma