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Flashcards in Haematology Deck (27):
1

What is pancytopaenia?

red in rbc, white cells, platelets

2

5 causes of pancytopenia?

sle, bone marrow failure, hypersplenism, megaloblastic anaemia, haemoglobin uraemia

3

5 symptoms of pancytopenia

anameia, bleeding, fatigue, infections, headache, menstrual, epistaxis, petichiae

4

Invest and treatment of pancytopenia

one marrow biopsy, treat cause

5

catogorise the causes of neutropenia, give 3 eggs of each

low product 1- bone marrow malignancy, 2 aplastic anaemia, 3 chemo

normal productopn 1-feltys, hypersplenism, 3 malaria

6

symtpoms neutropenia

recurrent infections (staph)

7

inx for neutropenia

FBC, blood cultures, septic screen

8

how to do blood cultures

2 sets, peripheral vein plus indwelling census catheter

9

management neutropenia

tazocin

10

Indications for bone marrow replacement (3)

1 aplastic anaemia (bone marrow failure), 2 leukaemia, 3 lymphoma, 4 myeloma

11

what is Acute lymphocutic leukaemia

malignancy of B cells

12

2 genetic translocations ALL

12;21 (most common), 9:22 (philadelphia)

13

symp of ALL (5)

fatigue
dizziness
palps
recurrent infections
fever no obvious cause
splenomegals
headahce
DIC

14

Inx for ALL

FBC, blood films, clotting, egg, echo, bone marrow asp +biopsy

15

management for ALL

Short term CT, blood transfusions, box,

16

what is AML

malignancy of bone marrow

17

RF for AML (3, 2 congenital)

aplastic anaemia, polycythaemia rubra vera congenital - downs, fanconis

18

3 sx for aml

bone pain
fatigue
dizzy
fever
splenomegaly

19

inx for aml

fbc, clotting, LDH, bone marrow

20

mx for aml

ct, stem cell transplant

21

CML

malignancypluripotent haemopoetic stem cells

22

genetic abnormality CML (1)

9,22 philadelphia

23

sx cml (3)

fatigue, night sweats, weight loss, splenomegaly, hepatomegaly, lymphadenopathy

24

mmx cml

tyrosine kinase i

25

CLL

malignant monoclonal expansion of b lymphs, accumulation of glyphs in blood, bone marrow, spleen

26

sx of CLL (4)

fatigue, lymph nodes, bleeding, petechiae, tiredness, splenomegaly

27

Inx for CML

clonal bcell lymphocytosis, bone marrow aspirate (lymphocytic replacement of normal marrow elements), immunophenotyping