MSK Flashcards Preview

In brief conditions > MSK > Flashcards

Flashcards in MSK Deck (36):
1

definition seronegative arthitides

inflammatory rheum disease, inflammation of axial and peripheral joitns and enthesitis (inflammtion where tnedon meets bone)

2

extra articular features seronegagive

anterior uveiitis and bowel lesions

3

3 conditions under umbrella sero -ve

ank spond, rieter's, enteropathic, psoriatic, behcet's, Junior idiopathic

4

RF sero -ve

fam hx, HLA b27

5

3 symptoms sero -ve

inflammatoy back pain, stiff in morning, sacroiliitis, enthesitis, sausage fingers, urethritis,

6

Inv for sero -ve

ESR and CRP, urte, RF, antinulcear, serology testing, xray sacroiliac joints (inflammation), bamboo spine, sqauring of vertebrae

7

management sero -ve

physio, NSAIDS< DMARDS, joint replacement

8

pathophys of Pagets

inc bone turnover, inc activity of osteoclasts, new bone weak and brittle

OLD PEOPLE

9

symptom pagets

bone pain, at night, bone deformity (bowing tibia, kyphosis, bossing skull), deafness and tinnitus

10

inv for pagets

raised ALP, normal ca and po4

xray - skull - cotton wool pattern - multifocal sclerotic patches

11

management pagets

orthotics, sticks, walkers
nsaids
BISPHOSPHONATES

12

osteomalacia

(is rickets when childern)
inadeqaute mineralisation VIT D!!!!, results in loss of skeletal mass

13

symptoms osteomalaci

pain, prox muscle weakness, skeletal deformity - vertebrae a skull, change in gait, fractures

14

bloods osteomalacia

high alk phos, FBC
xray - looser's zones

15

management osteomalacia

vit D supps, dietary get ou in sun

16

primar y benign bone tumour

osteoid, cartilage -- chondroma, firbous -- fibroma, bone marrow -- eosinophillic granuloma, vascular -- haemoangioma

17

secondary malignant bone mets

osteosarcoma, chondrosarcoma, fibrosarcoma, ewings, angiosarcoma

18

symptoms bone tumour

patho fract, growth and malignany

19

SLE definition

chronic AI condition, multi system, antinuclear antibodies occur

20

RF SLE

DR2 DR3, UV light, methyldopa

21

sx SLE

relapses and remits (remember weird finnish woman)
maliaise, fever, fatigue, splenomegaly, lymphadenopathy, weight loss

joint muslce pains, EMstifness,

butterfly rash, sparing nasolabial folds,

discoid lupus - sun exposed areas, erythematous, well demarcated, scaling

headache,

raynauds

dry eyes and mouth

fucking everything

22

Inv SLE

anaemia, leukopenia, thrombocytopenia, auto ab - ANA, anti dsDNA

23

management SLE

avoid sun, (think weird white finnish woman) hydroxychloroquine, cyclophosphamide

24

scleroderma def

widespread small vessel damage, fibrosis in skin and systemic organs

25

types of scleroderma (3)

pre-scleroderma (raynauds +antinulcear ab)

diffuse cutaneous (worst - raynauds + lung, heart, GI, renal disease)

limited cutaneous (middle best - CREST - calcinosis, raynauds, esopageal dys, scelrodactyly, telangiectasia)

26

Lung issues scleroderma

pul fibrosis

27

heart issues scleroderma

pericarditis, pericardial effusion, myocardial fibrosis, heart failure

28

GI issues scleroderma

dry mouth, dysmotilithy, constipation, reflux, watermelon stomach,

29

blood tests sclero

antinuclear antobodies

anti centromer, anti scl 70 (anti topoisomerase)

30

other inv sclero (think about issues that arise)

ecg, echo, endoscopy, barium studies, U+E , radiography, skin biopsy§

31

management sclero
skin, raynauds, lung, GI, renal, myositis

skin - moisturisers, lasers,

raynauds - keep warm,long acting CCB (nifedipine) add phosphodiesterase i (sildenafil)

lung - pul hypertension - bosentan, sildenafil

GI - PPI, promotility, pancreatic supps, PEG feed,

renal - acei

32

most common causative agents septic arthritis

staph, haemophilus, coliforms

33

in septic arthritis of hip, how is joint held?

flexed, slightly externally rotated

34

sepsis in prosthetic joint

remove prosthesis before full eradication is possible

35

clinical features temporal arteritis

headache, temporal or occipital, severe, worse at night

36

visual manifestations of temporal arterial disease

blurred vision, amaurosis fugax