Haematology

Question 1

AML - adverse prognosis

Answer 1

Clinical - age > 75, ECOG > 1, prior MDS/MPN, t-AML, high WCC
Cytogenetic - inv(3), t(6:9), t(v:11q23), -5/5q-, -7, abn(17p), complex
Molecular - RUNX1, TP53, ASXL1

Question 2

AML - favourable prognosis

Answer 2

Cytogenetic - inv(16), t(8:21), t(15:17)

Molecular: NPM1, CEBPa

Question 3

B ALL high risk

Answer 3

Age > 35, WCC >30, pro-B, no CR after 4 weeks, Philadelphia chromosome, IK2F1 mut, JAK2 mut, MLL translocation, hypodiploid or complex

Question 4

T ALL high risk

Answer 4

Age > 35, WCC >100, pre-T, no CR after 4 weeks, N/K RAS mut, PTEN mut, NOTCH/FBXW7 wt