Receptors present on sentinal cells that detect structurally conserved molecules derived from microbes - TLR 1 and 2 bind extracellular bacterial lipopeptides and peptidoglycans - TLR 3 binds intracellular dsRNA from viruses - TLR 4 binds extracelular lipopolysaccharides promoting macrophage activation and cytokine storm - TLR 5 binds extracellular bacterial flagellin

Immunology Flashcards by Jonathan Abdelmalak

TLR

Receptors present on sentinal cells that detect structurally conserved molecules derived from microbes

TLR 1 and 2 bind extracellular bacterial lipopeptides and peptidoglycans
TLR 3 binds intracellular dsRNA from viruses
TLR 4 binds extracelular lipopolysaccharides promoting macrophage activation and cytokine storm
TLR 5 binds extracellular bacterial flagellin

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