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POM 1a - Haematology > Haemeostasis > Flashcards

Haemeostasis Flashcards

1
Q

What do chemicals do endothelial cells secrete to prevent coagulation?

A

Nitric oxide

PGI2

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2
Q

What do nitric oxide and PGI2 do?

A

Inhibit platelets

Keeps inactive

Prevent from binding to endothelial layer

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3
Q

What glycosaminoglycan are present on the endothelial cell to prevent coagulation?

A

Heparin sulphate

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4
Q

What does heparin sulphate do?

A

Binds to antithrombin 3

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5
Q

What does antithrombin 3 do?

A

Inactivates CF II, IX , X

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6
Q

What protein is present on endothelial cells to prevent coagulation?

A

Thrombomodulin

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7
Q

What does thrombomodulin do?

A

Binds to thrombin (CF II)

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8
Q

What does thrombin do?

A

When protein C moves across it it becomes activated

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9
Q

What does activated protein C do?

A

Degrades CF V, VIII

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10
Q

What do injured endothelial cells secrete?

A

Endothelin

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11
Q

What does endothelin do?

A

Binds to receptors on smooth muscle cells and causes smooth muscle contraction —> vascular spasm

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12
Q

What happens when there is a direct injury to the smooth muscle?

A

Activation of myogenic mechanism

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13
Q

What does the myogenic mechanism cause?

A

Muscle contraction —> vascular spasm

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14
Q

What do inflammatory chemicals stimulate in order to cause vascular spasms?

A

Noicocepto activation

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15
Q

For platelet plug formation what do endothelial cells produce?

A

VWF

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16
Q

How do platelets bind to VWF?

A

Glycoprotein 1b (Gp1b) on platelet binds to VWF

17
Q

What happens when platelets bind to VWF?

A

Platelets start secreting chemicals

18
Q

What chemicals do platelets secrete?

A

ADP

Thromboxane A2

Serotonin

19
Q

What do ADP and thromboxane A2 do?

A

Stimulate platelets in circulation —> causes them to aggregate and form a plug

20
Q

How do platelets bind to each other?

A

Platelets have protein GpIIB/IIIa which have fibrinogen between them —> link platelets together

POM 1a - Haematology (6 decks)

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