haemostasis and fibrinolysis

Question 1

FI

Answer 1

fibrinogen, for coagulation

Question 2

FII

Answer 2

thrombin, converts fibrinogen into fibrin, coagulation

Question 3

FIII

Answer 3

TF, together with coagulation factor VIIa does it bring FX to an active form

Question 4

FIV

Answer 4

calcium ion

Question 5

FV

Answer 5

will help speed up the reaction of II to IIa

Question 6

FVII

Answer 6

together with FVIIa able to bring coagulation factor X to an active form

Question 7

FVIII

Answer 7

binds to VWF, when let go it will interact with IX in order to stimulate FX

Question 8

FIX

Answer 8

together with Ca2+ and VIII it converts X to active form

Question 9

FX

Answer 9

able to bring II to active form

Question 10

FXI

Answer 10

activates factor IX

Question 11

FXII

Answer 11

converts XI and PL into active form

Question 12

FXIII

Answer 12

makes crosslinks between the D domains of fibrin monomers

Question 13

HMWK

Answer 13

participates in the initation of blood coagulation, helps activating XII and XI

Question 14

PK

Answer 14

ihelps HWMK with activating XII

Question 15

protein C

Answer 15

converst Va and VIIIa into inactive form

Question 16

protein S

Answer 16

cofactor to protein C in the inactivation of factors Va and VIIIa

Question 17

plasmin

Answer 17

a protease that is able to degrade the fibrin in order to make it soluble again

Question 18

thrombomodulin

Answer 18

needed to activate protein C

Question 19

TFPI

Answer 19

inhibits Xa by generating a Xa-TFPI complex

Question 20

antithrombin III

Answer 20

inhibits thrombin, IIa, IXa and XIa

Question 21

fibrin

Answer 21

costimulator to converts plasminogen to plasmin

Question 22

tPA

Answer 22

together with fibrin converts plasminogen to plasmin

Question 23

uPA

Answer 23

can convert plasminogen to plasmin

Question 24

PAI-1

Answer 24

inhibits tPA and uPA

Question 25

A2AP

Answer 25

inhibits plasmin

Question 26

TAFI

Answer 26

deleys plasmin generation and fibrin degradation

Question 27

thrombin

Answer 27

converts protein C into APC

Question 28

bernard soulier syndrome

Answer 28

autosomal recessive disease in which GPib can not bind to VWF

Question 29

glanzmann thromasthenia

Answer 29

GPIIb/IIIa does not function properly and VWF can no longer be liked between platelets, you can not form a plug

Question 30

storage pool disease

Answer 30

defects in release reaction

Question 31

kidney failure

Answer 31

due to kidney failure you can have uremia

Question 32

liver cirrhosis

Answer 32

due to liver cirrhosis you will bleed more

Question 33

what does aspirin and NSAID (reversible) do

Answer 33

it inhibits COX and thus you will have less TxA2. thus you will have less platelet aggregation

Question 34

what doe clopidogrel, prasugrel and ticagrelor do

Answer 34

inhibit the ADP receptor

Question 35

what does abciximab do

Answer 35

inhibits GPIIb/IIIa

Question 36

type 1 VWF

Answer 36

partial deficiency of VWF due to reduced synthesis of normal VWF or intracellular retention of VWF

Question 37

type 2A VWF

Answer 37

due to lack of high molecular weight multimers smaller vWF

Question 38

type 2B VWF

Answer 38

increased affinity for GPIb which causes spontaneous binding to the receptor without subendothelial collagen exposed

Question 39

type 2M VWF

Answer 39

mutation in the protein where it cna not interact with the receptor anymore; reduced binding affinity for the platelets

Question 40

type 2N VWF

Answer 40

factor VIII has a reduced affinity and thus there is reduced secondary haemostasis

Question 41

type 3 VWF

Answer 41

complete deficiency of VWF