Head Injury Flashcards

(31 cards)

1
Q

How would you classify head injury

A

Type of injury
Distribution of lesions
Time course of damage following the traumatic event

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2
Q

Examples of type of injury (which is more common)

A

Non-missile (more common)

Missile head injury

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3
Q

What is meant by missile head injury

A

Head injury in which there is penetration of skull or brain

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4
Q

Examples of distribution of lesions

A

Focal

Diffuse brain lesions

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5
Q

Categories of time course of damage following the traumatic event

A

Primary

Secondary

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6
Q

What is meant by Primary time course of damage following the traumatic event

A

Due to immediate biophysical forces of trauma

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7
Q

What is meant by Secondary time course of damage following the traumatic event

A

Presenting some time after the traumatic event:

  • Physiological responses to trauma
  • Effects of hypoxia/ischaemia
  • infection
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8
Q

What is non-missile

A

Blunt head trauma

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9
Q

Focal damage after non-missile trauma

A

Scalp
Skull (fracture)
Meninges
Brain

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10
Q

Focal damage to scalp after non-missile trauma

A

contusions

lacerations

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11
Q

Focal damage to meninges after non-missile trauma

A

Haemorrhage

Infection

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12
Q

Focal damage to brain after non-missile trauma

A

Contusions (bruise)
Lacerations
Haemorrhage
Infection

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13
Q

Diffuse brain lesions as result of non-missile trauma

A

Diffuse axonal injury
Diffuse vascular injury
Hypoxia-ischaemia
Swelling

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14
Q

What can result from skull fracture (implies considerable force)

A

Increased risk of haematoma, infection and aerocele

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15
Q

What can cause skull fracture

A

Angled or pointed objects cause localized fractures that are often open or depressed
Flat surfaces cause linear fractures
Can extend to skull base

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16
Q

Examples of haemorrhage (focal lesion)

A

Extradural haematoma
Subdural haematoma
Traumatic subarachnoid haematoma
Cerebral and cerebellar haemorrhage

17
Q

Cause of superficial and deep cerebral/cerebellar haemorrhage

A

Superficial - due to severe contusion

Deep - related to diffuse axonal injury

18
Q

Describe extradural haemorrhage

A
~15% of fatal head injurys (~10% of severe ones)
Occur slowly over hours
Causes death by brain displacement
Raised intracranial pressure
Herniation
19
Q

Describe subdural haematoma

A

Usually due to tears in bridging veins (cross subdural space form superior surface of brain to mid-sagittal sinus
Can occur slowly
Usually surrounded by ‘membrane’ of granulation tissue

20
Q

Causes of traumatic subarachnoid haemorrhage

A

Contusions/lacerations
Base of skull # (tear vessels)
Vertebral artery rupture/dissection
Intraventricular haemorrhage

21
Q

Main cause of infection in brain

A

Skull fracture

22
Q

Focal brain damage mechanisms

A
Contact damage (at or just deep to the point of impact)
Acceleration or deceleration damage (force to head causes differential movement of skull and brain or get differential movement of brain tissue)
23
Q

What can result from differential movement of brain tissue

A

Shearing, traction and compressive stresses

Damages blood vessels and axons

24
Q

What can result from differential movement of skull and brain (as result of force to head)

A

Impact of inner surface of skull on underlying brain causes contusion
Traction on bridging veins causes subdural haemorrhage

25
What are contusions
Superficial bruises of the brain
26
What is difference between coup and contre coup contusions
coup = at site of impact | contre coup = away from site of impact
27
Describe how contusions change over time
At first - haemorrhagic Then become brown/orange and soft (days weeks) Then indented or cavitated (after months or years)
28
When do lacerations happen
When contusion is sufficiently severe to tear the pia mater
29
Example diffuse lesions
Diffuse axonal injury Diffuse vascular injury Swelling Hypoxia-ischaemia
30
Pathophysiology of chronic traumatic encephalopathy
Atrophy: -neocortex, hippocampus, diencephalon & mamillary bodies Enlarged ventricles with fenustrated cavuum septum Tau-positive neurofibrillary and astrocytic tangles: -Frontal and temporal cortex and limbic regions -Especially around depths of sulci and limbic regions
31
What % of chronic traumatic encephalopathy is TDP-43 pathology
~85%