Head & Neck Flashcards
(214 cards)
Carcinoma ex pleomorphic adenoma is subdivided into what 3 prognostic subtypes?
Noninvasive, minimally invasive, and invasive. Noninvasive carcinomas arising in PA are sometimes referred to as in situ or intracapsular carcinomas. These tumors are characterized by relatively abrupt transitions between histologically bland PA and areas with obviously malignant cytologic features but are limited to the confines of the PA without extracapsular invasion. The noninvasive carcinoma may invade the matrix of the preexisting PA but is not considered clinically invasive until it penetrates beyond the capsule of the PA. Minimally invasive CaExPA is defined as a carcinoma that invades no more than 1.5 mm beyond the capsule of the PA. Distinguishing between a benign pseudopod and true invasion may be difficult. A desmoplastic reaction, if present, is helpful. So-called lateral extension (mushroom-type invasion) into and through the capsule, akin to that seen in some thyroid carcinomas, also implies malignancy, as does perineural invasion. In addition, the invasive component should demonstrate atypical cytologic and architectural features.
Discuss the 3 growth patterns seen in adenoid cystic carcinoma.
Cribriform, tubular, and solid. The cribriform subtype is the MC. It is composed of islands of basaloid cells surrounding variably sized cystlike spaces forming a “Swiss cheese” or sievelike pattern. The cystlike spaces are referred to as “pseudocysts” b/c they do not represent true glandular lumina and are contiguous with the surrounding stroma. The pseudocysts contain basophilic glycosaminoglycans and/or eosinophilic, PAS-positive basal lamina material. Rare, true glandular lumina composed of cuboidal cells showing ductal differentiation can also be found scattered throughout and their presence greatly aids in diagnosis. The tubular pattern shows similar cytology with the tumor cells arranged in nests surrounded by variable amounts of eosinophilic, often hyalinized stroma. Occasionally, the stromal component is increased, compressing the tumor cells into thin strands, forming a “trabecular” pattern. Well-formed ducts with recognizable inner epithelial and outer myoepithelial layers are more prominent than in the cribriform pattern. The continuity of the pseudocysts with the surrounding stroma is also more prominent. The solid pattern contains aggregates of basaloid cells without tubular or cystic formation. Although the basaloid cytology of the tumor cells is retained, the tumor cells may be larger and nuclear pleomorphism may be more pronounced. Mitoti figures and comedonecrosis may also be seen. As in the cribriform pattern, true ducts will occasionally be seen scattered among the sheets of cells. This feature, along with accompanying areas of cribriform or tubular growth, can aid in differentiation from other basaloid neoplasms. A combination of patterns can be seen, which could be considered a fourth pattern.
Malignant mixed tumors of the salivary glands can be classified as what 3 types?
- Carcinoma ex pleomorphic adenoma. 2. “Benign” metastasizing pleomorphic adenoma. 3. Carcinosarcoma. >90% of all malignant mixed tumors are CaExPAs and most are high grade, with salivary duct carcinoma; adenocarcinoma NOS; undifferentiated carcinoma; and myoepithelial carcinoma being the most common subtypes.
Myoepithelial neoplasms of the salivary glands.
Some authors believe these should be purely myoepithelial, while some believe a minor ductal component can be present (typically <5%). Myoepithelial neoplasms can be benign (myoepithelioma) or malignant (myoepithelial carcinoma or malignant myoepithelioma). 10-20% are malignant. MC sites are parotid gland and palate. Most myoepitheliomas occur in the 5th and 6th decades of life and most myoepithelial carcinomas occur in the 6th and 7th decades of life. Myoepithelial tumors can be difficult to recognize histologically because of variety in their architectural and cytologic appearances. 6 characteristic growth patterns of myoepithelial tumors: solid, nodular, mucinous, trabecular, pseudoglandular, reticulated. 5 characteristic cell types of myoepithelial tumors: spindled, plasmacytoid-hyaline, clear, epithelioid, oncocytic.
Nasolabial cysts.
The nasolabial cyst is a benign, slow-growing, locally expansile lateral extraosseous lesion below the nasal ala and the medial nasolabial fold. Although often classified as a jaw cyst, the nasolabial cyst is purely a cyst of soft tissue. Alternative, older, or less common names for this lesion include Klestadt cyst, nasal vestibule cyst, nasal wing cyst, and mucoid cyst of the nose. Because the cyst does not involve the dental alveoli, the sometimes also encountered term nasoalveolar cyst is not recommended. Nasolabial cysts can be observed at any age, but MC in 30-50 yo, and F:M = ~3:1. They are typically unilateral and slow-growing. They are found near the distal portion of the nasolacrimal duct and its opening into the inferior nasal meatus. It is believed that nasolabial cysts are hamartomatous developmental lesions, arising from the lower anterior portion of the nasolacrimal duct. Grossly, nasolabial cysts are pink to tan, soft to rubbery-firm, and have variably cystic and fibrous areas filled with clear viscous fluid. Histologically, there is a bilayered epithelium with a cuboidal basal layer and a columnar luminal layer that contains interspersed scattered mucinous goblet cells. To variable extents, nasolabial cysts can also be lined by multilayered or pseudostratified, cuboidal to columnar epithelium. Focal squamous metaplasia or apocrine changes may also be present. Ciliated cells are not present. Cyst wall stroma is composed of hypocellular, collagen-rich fibrovascular tissue with variable amounts of chronic inflammatory cells.
Osteoblastomas associated with a tooth root are called ___.
Osteoblastomas associated with a tooth root are called cementoblastomas. Osteoblastoma occurs more often in the mandible than the maxilla. It is often associated with the root of a tooth, where it forms an ossified, well-demarcated tumor. Microscopically, the bony matrix tends to be abundant in these tumors and to radiate from the tooth root in parallel arrays.
Papillary thyroid carcinoma, cribriform morular variant. What stains can be helpful? This variant is associated with (syndrome) ~25% of the time.
This variant’s unique histology and reactivity with thyroglobulin, TTF-1, and beta-catenin help to distinguish it. This variant is associated with FAP ~25% of the time.
Papillary thyroid carcinoma, diffuse sclerosing variant. In what age group does it occur? What is the histologic appearance?
A rare variant that occurs in children and young adults. It has conventional papillary architecture and PTC nuclear features, but has squamoid changes and abundant psammoma bodies, a dense lymphocytic and sclerotic background, and extensive lymphatic permeation.
Papillary thyroid carcinoma, oncocytic variant. What is the gross and histologic appearance?
This variant is grossly mahogany brown. Microscopically, while it has conventional papillary architecture, it is oncocytic with focally prominent nucleoli and often has psammoma bodies (about 33 %).
PIOLs?
Primary Intraocular Lymphomas. Is a subset of PCNSL. Is usually a DLBCL. They arise from the retina (a suggested renaming for PIOL is primary retinal lymphoma) and rarely from the uvea. Usually presents as a chronic intermediate uveitis unresponsive to corticosteroids in a median age in the 60s. The Dx is based on ID of atypical lymphoid cells in the eye, but b/c PIOL is a subset of PCNSL, the Dx can be made if the lymphoma cells are found in CSF, and an LP is less invasive than a diagnostic vitrectomy or a vitreous or aqueous aspiration anyway. The atypical lymphoid cells are usually large and pleomorphic, with scant basophilic cytoplasm and large nuclei. Other findings include hypersegmented, round, or clover-shaped nuclei with prominent nucleoli and rare mitoses.
Pleomorphic adenoma of salivary gland?
AKA benign mixed tumor. MC salivary gland tumor, accounting for almost 2/3 of all salivary gland tumors. PAs are composed of both epithelial cells and myoepithelial cells, which produce a mesenchymal stromal component that is often myxoid or chondromyxoid. Varying amounts and arrangements of the epithelial, myoepithelial, and stromal components give rise to a broad degree of morphologic diversity. The distinction between a cellular PA, basal cell adenoma, or myoepithelioma can be subjective. An acellular PA can resemble a soft tissue chondroma or myxoma. ~6% of PAs harbor malignancy. PAs are usually well circumscribed and encapsulated in the major salivary glands and nonencapsulated in the minor salivary glands.
Polymorphous low-grade adenocarcinoma of the salivary glands?
PLGA occurs almost exclusively in the minor salivary glands of the oral cavity and oropharynx. They tend to be nonpainful and slow growing, M:F = 1:2, and occurs over a broad age range (average 50-60). Histologically, PLGA is characterized by a triad of infiltrative growth, multiple architectural growth patterns, and cytologic uniformity. Characteristic growth patterns include solid, trabecular, glandular, cribriform, fascicular, cordlike and papillary, with the first 3 patterns being the MC. Typically, the central portion consists of the more solid growth patterns, with the glandular and cordlike elements seen more often at the periphery. Mitoses are rare and necrosis is unsually not seen. PNI is common and can have a targetoid arrangement which is very characteristic of PLGA. The tumor cells are cytologically bland and can be cuboidal, columnar, or spindled, with a mixture being most common.
Salivary duct carcinoma.
SDC is one of the most aggressive salivary gland carcinomas and histologically resembles HG ductal adenocarcinoma of breast. Can be seen in a wide age range but most are in >50 (mean of 60-79). M:F = 3-4:1. It can arise de novo or in the setting of a pleomorphic adenoma (SDCExPA). Parotid gland is the MC tumor site. Microscopically, SDCs are characterized by both infiltrative and intraductal carcinoma resembling breast ductal carcinoma. The most characteristic histologic feature is variably sized, rounded nodules with a cribriform, solid, cystic, or papillary architecture. These so-called ductal lesions frequently demonstrate comedo necrosis, which may undergo calcification. Cytologically high grade and numerous mitoses. The cells have moderate to abundant amounts of eosinophilic to amphophilic cytoplasm, fequently imparting an apocrine-like phenotype. For IHC, most tumors are positive for androgen receptor and SDC is now virtually defined by expression of this. SDCs are often positive for BRST-2 and CEA and >2/3 are positive for HER-2 overexpression, but almost all are negative for ER and PR. Prognosis is dismal.
The most common primary lymphoma subtype occuring in the ocular adnexa?
Low-grade, malignant, extranodal, marginal zone B-cell lymphoma of MALT type.
Uveal malignant melanoma?
… is the most common primary intraocular malignancy in the adult population. It comprises ~5% of all melanomas, and 85% of ocular melanomas are uveal in origin. Mortality, principally from liver metastasis, has historically been ~50%. Features correlating with poor prognosis include: large size, epithelioid cell type, presence of PAS positive vascular mimicry patterns (or extracellular matrix patterns), and ciliary body involvement. Chromosomal changes of prognostic significance include monosomy 3, and alterations of 8q and 6p.
What is HPT-JT syndrome?
HPT-JT (hyperparathyroidism-jaw tumor) syndrome is an inherited disorder with incomplete penetrance. The disorder may be characterized by parathyroid adenoma or carcinoma, benign fibro-osseous lesions of the mandible or maxilla, and renal cysts or tumors. Approximately 80% of patients have hyperparathyroidism and up to 15% of these patients have parathyroid carcinoma. The HRPT2 gene (for ‘‘hyperparathyroidism 2’’) is a putative tumor suppressor gene that was identified and has been mapped to 1q25–q31. The gene encodes a protein named parafibromin for its relationship to parathyroid disease and fibro-osseous jaw lesions. While HPT-JT syndrome is an exceedingly uncommon entity, with an unknown incidence or prevalence, like MEN, it should be considered in the differential diagnosis for the adolescent presenting with hyperparathyroidism.
What is the most common tumor of the paranasal sinuses?
Osteoma. Osteomas are benign, generally slow-growing, bone-forming tumors limited almost exclusively to craniofacial and jaw bones. They can be subdivided into bone surface tumors (or exostoses) that primarily involve the cranial vault, mandible, and external auditory canal and the more common sino-orbital (or paranasal sinus) osteomas that arise from bones that define the paranasal sinuses, nasal cavity, and orbit. Frontal, ethmoid, maxillary, and sphenoid sinuses are most frequently affected in that order. Histologically, while surface exostoses are usually formed of compact bone, sino-orbital osteomas are composed of variable amounts of compact and cancellous bone. Some osteomas have been designated as “osteomas with osteoblastoma-like features” and are difficult to distinguish from osteoblastomas or osteoid osteomas. Osteoblastoma is most commonly located in the vertebrae and long bones, but mandible is also a relatively common location, where it is often associated with the root of a tooth and referred to as cementoblastoma. However, primary osteoblastoma of the paranasal sinuses is very rare. Osteoid osteomas are vary rare in the craniofacial and jaw bones. They are distinguished from osteoblastoma only by size with a nidus usually less than 1 cm, since the histologic features are essentially indistinguishable. Microscopically, although focally indistinguishable from osteoblastoma, osteoma with osteoblastoma-like features has much more mature bone in the form of solid/compact (ivory osteoma) and dense cancellous (mature osteoma) bone. In addition, the outer contour of an osteoma has a smooth rounded surface, often lined by respiratory mucosa, representing the outer surface of its polypoid growth within the sinus cavity. True osteoblastomas, in contrast, will from an expansible intramedullary or periosteal bone tumor.
What HPV types (in order of frequency) are seen mostly commonly in the following lesions? Plantar wart, common wart, flat (juvenile) wart, oral squamous papilloma, oral focal epithelial hyperplasia (Heck disease), epidermodysplasia verruciformis, laryngeal papillomas, condyloma acuminatum, cervical LSIL, cervical HSIL, cervical AIS and invasive cervical adenocarcinoma.
Plantar wart: 1, 2. Common wart: 2, 1, 4, (HPV 7 in fish and meat handlers). Flat (juvenile) wart: 3, 10. Oral squamous papilloma: 6, 11. Oral focal epithelial hyperplasia (Heck disease): 13, 32. Epidermodysplasia verruciformis: 2, 3, 10, 5, 8. Laryngeal papillomas: 6, 11. Condyloma acuminatum: 6, 11. Cervical LSIL: 6, 11. Cervical HSIL: 16, 18, 31, 33, 35. Cervical AIS: 18. Invasive cervical adenocarcinoma: HPV 16 and 18 are detected with equal prevalence in most subtypes of cervical adenocarcinoma.
What are 2 risk factors for development of ameloblastoma?
Dentigerous cyst. Impacted teeth.
___% of medullary thyroid carcinomas occur in a relatively young population in association with MEN2 syndrome; the remainder are sporadic and may occur at any age.
15-20% of medullary thyroid carcinomas occur in a relatively young population in association with MEN2 syndrome; the remainder are sporadic and may occur at any age.
How does medullary thyroid carcinoma appear on FNA?
FNA biopsy yields neoplastic neuroendocrine cells and amyloid in variable proportions. The cellularity of the smears is usually inversely proportional to the amount of amyloid produced by the tumor. The neoplastic cells are dispersed or form loose clusters, rarely forming microfollicles or papillae. MTC is a great mimicker. The tumor cells may have spindly, plasmacytoid, polygonal, hurthloid or giant cells appearances; may demonstrate mild pleomorphism; and may be bi- or multinucleated. The nuclei often have a “salt-and-pepper” or “speckled” chromatin pattern on Pap stain. Nucleoli may be seen, but are usually inconspicuous. Intranuclear cytoplasmic inclusions are frequently identified, and are morphologically identical to those seen in papillary thryoid cancer. Mitotic figures are present in 15% of cases. On Diff-Quik staining, red cytoplasmic granules, corresponding to neurosecretory granules containing calcitonin, may be seen.
What is seen on FNAs in Hashimoto thyroiditis?
Smears from Hashimoto’s thyroiditis show a polymorphous lymphoplasmacytic infiltrate with germinal center formation. Lymphoid tangles, lymphohistiocytic aggregates, tingible body macrophages, and background lymphoglandular bodies may be the overwhelming findings on the smears. Multinucleated histiocytes may be seen. Oncocytic (Hurthle cell) metaplasia is usually prominent. Hurthle cells are epithelial cells with abundant, finely granular cytoplasm and enlarged, variably sized, typically round nuclei that may display prominent nucleoli.
Warthin’s tumor epidemiology.
Warthin’s tumor AKA papillary cystadenoma lymphomatosum AKA adenolymphoma is the second most common benign neoplasm of salivary glands. It arises from ducts trapped during embryologic development of lymph nodes in the parotid glands, explaining why Warthin’s tumor almost always occurs in or around the parotid gland. It often affects people in the fourth to seventh decades of life, with M:F=5:1. Smokers have a higher risk of developing Warthin’s tumors. Warthin’s tumor are multifocal in ~25% of patients and are bilateral in ~5-7.5%. Most of them are cystic, feel “doughy” upon palpation, and yield cloudy fluid on FNA.
How does Warthin’s tumor appear on FNA?
Most of them are cystic, feel “doughy” upon palpation, and yield cloudy fluid on FNA. Smears are hypocellular, but scattered flat sheets of oncocytic cells and lymphocytes are likely to be found. Corpora amylacea and mast cells may be seen. Aspiration of more peripheral solid regions of the lesion may yield more cells. Oncocytic metaplasia is common in elderly males. Therefore, identification of all three components - oncocytic cells, lymphocytes, and cyst contents - is important for diagnosis.