Headache Flashcards

1
Q

How is headache divided?

A

Primary Headache

  • Most headache (90% GP vs 60% A+E)
  • No underlying medical cause

Secondary Headache

  • Has identifiable structural or biochemical cause
  • Not all secondary is sinister
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2
Q

Give examples of primary headache

A

Tension Type Headache
Migraine
Cluster Headache

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3
Q

Give examples of secondary Headache

A
Tumour
Meningitis
Vascular disorder
Systemic infection
Head injury
Drug-induced
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4
Q

What is Primary headache?

A

Increased sensitivity of normal intracranial pain pathways to what is going on in the environment

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5
Q

Describe tension-type headaches

A

Most frequent primary headache, but is NOT disabling and rarely presents to doctors

Lifetime prevalence of 42% in men and 49% in women

Mild, bilateral headache which is often pressing or tightening in quality, has no significant associated features and is not aggravated by routine physical activity

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6
Q

What is the difference between Infrequent ETTH, Frequent ETTH and CTTH?

A

Infrequent Episodic Tension-Type Headache (/= 15 days / month)

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7
Q

What is the treatment for tension-type headache?

A

Absorptive treatment:

  • Aspirin or paracetamol
  • NSAIDs
  • Limit to approx 2 days per week to avoid the development of medication overuse headache

Preventative treatment:
-Rarely required
-Tricyclic antidepressents
(AMITRIPTYLINE, dothiepin, nortriptyline)

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8
Q

What is migraine?

A

A chronic disorder with episodic attacks

Complex charges in the brain that lead to activation and sensitisation of the trigeminal system

Most frequent DISABLING primary headache

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9
Q

What are the symptoms during attacks of migraine?

A

One of the following symptoms should be present along with headache:

  • Nausea and/or vomiting
  • Photophobia,
  • Phonophobia
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10
Q

What are the symptoms between attacks of migraine?

A

Enduring predisposition to future attacks

Anticipatory anxiety

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11
Q

What is the criteria for a migraine?

A

Both with an without aura, headaches must last for 4 to 74 hours.

In addition the headaches must have at least 2 of the following features:
-Unilateral location
-Pulsating quality
-Moderate or severe pain
and/ or aggravation by or causing avoidance of routie physical activity (e.g. walking, climbing stairs

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12
Q

What are the triggers of migraines?

A
STRESS
Hunger
Sleep disturbance
Dehydration
Diet
Environmental stimuli
Changes in oestrogen levels in women
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13
Q

How does migraine evolve over time?

A

Migraine is manifested clinically as a constellation of symptoms that evolve through the various phases of a migraine attack.

Clinical experience indictaes that symptoms typically associated with each phase of an attack often recur during other pases of the attack, resulting in continuum of symptoms, rather than a succession of distinct phases.

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14
Q

Describe the premonitory phase of a migraine attack

A

70% with or without aura experience premonitory symptoms

Often seen as predictors of the headache attack

Mood alterations, muscle pain, food cravings, cognitive changes, fluid retention, yawning

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15
Q

What is an aura?

A

Transient neurological symptoms resulting from cortical or brainstem dysfunction

May involve visual, sensory, motor or speech symptoms
-Show a slow evolution of symptoms from 1 area to the next (e.g. vision -> sensory -> speech)

Aura symptoms are believed to arise from an electrical disturbance called cortical spreading depression (CSD)

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16
Q

Describe the aura phase of migraine

A

Involves focal, fully reversible neurologic symptoms that often precede headache.

Visual somatosensory symptoms often described

Duration = 15-60 mins

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17
Q

Describe the early headache phase of migraine

A

Mild pain without the associated symptoms of migraine

Nasal congestion

Muscle pain

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18
Q

Describe the advanced headache phase of migraine

A

Moderate to severe unilateral throbbing pain with associated symptoms of:
-Nausea, photophobia, phonophobia or disability.

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19
Q

Describe the postdrome phase of migraine

A

Phase of migraine associated symptoms beyond the resolution of the headache (often entails significant disability that can last for 1 or 2 days)

Fatigue
Cognitive changes
Muscle pain

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20
Q

Summarise the phases of migraine by listing them in order

A
Premonitory
Aura
Early headache
Advanced headache
Postdrome
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21
Q

What can aura symptoms be confused with?

How do you differentiate?

A

TIA:

TIA differs in that it involves:

  • Loss of function
  • Sudden onset
  • Symptoms all start at same time and can be localised to a specific vascular area
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22
Q

What is chronic migraine?

A

Headache on >/= 15 days per month, of which >/= 8 days have to be migraine, for more than 3 months

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23
Q

What is Medication Overuse Headache?

A

Headache present on >/= days/month which has developed or worsened whilst taking regular symptomatic medication

Can occur in any primary headache:

  • Migraineurs are particularly prone to MOH
  • Migraineurs taking pain medication for another reason can develop chronic headache
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24
Q

What causes Medication Overuse Headache?

A

Use of triptans, ergots, opioids and combination analgesics >10days/month

Use of simple analgesics >15 days per month

Caffeine overuse: coffee, tea, cola etc

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25
What is the abortive treatment for migraine?
- Aspirin or NSAIDs - Triptans - Limit to approx 2 days per week to avoid medication overdose headache
26
What is the prophylactic treatment for migraine?
- Propranolol, Candesartan - Anti-epileptics (Topiramate, Valproate, Gabapectin) - Tricyclic andtidepressents (amitriptyline, dothiepin, nortiptyline) - Venlafaxine
27
How is migraine effected in pregnancy?
Migraine without aura gets better in pregnancy Migraine with aura usually doesnt change First migraine can occur during pregnancy -Particularly migraine with aura
28
Why should you avoid anti-epileptics in a woman of child bearing age?
Teratogenicity of medication Ensure adequate contraception
29
How is the treatment of migraine different in pregnancy?
Treatment is more difficult Acute attack: Paracetamol Preventative: Propanolol or Amitriptyline No anti-epileptics
30
What are the Trigeminal Autonomic Cephalalgias?
Cluster Headache Paroxysmal Hemicrania SUNCT = Short-lasting Unilateral Neuralgiform headache with Conjunctival injection and Tearing SUNA = Short-lasting Unilateral Neuralgiform headache with Autonomic symptoms
31
What is the attack in Cluster Headache like?
Pain = mainly orbital and temporal ``` Attacks are UNILATERAL Radip onset ( ```
32
What migrainous symptoms are often present in cluster headache?
Premonitory: tiredness, yawning Associated symptoms: nausea, vomiting, photo- and phonophobia Typical aura
33
What autonomic symptoms may be present in Trigeminal Autonomic Cephalalgias?
``` Conjunctival injection Nasal congestion Eyelid oedema Forehead and facial swelling Miosis/ ptosis ```
34
Describe the bouts in Cluster Headaches?
Episodic in 80-90% -Attacks cluster into bouts lasting about 1-3 months with periods of remision lasting at least a month - Frequency: 1 every day to 8 per day - May be continuous backgorund pain between attacks Alcohol triggers attacks during a bout but not in remission
35
How does circadian rhythm play a role in cluster headache?
Attacks occur at the same time each day Bouts occur at the same time each year
36
10-20% of patients who have cluster headaches have chronic cluster headache. What is this?
Bouts last >1 year without remission or... | Remission last
37
Describe Paroxysmal hemicrania
Attack frequency: 1-40 per day -(1-8 in Cluster) Duration of attack: 2-30mins (15-180mins in Cluster Pain quality: Sharp throbbing (Cluster = same) Pain intensity: very severe (Cluster = same) Circadian periodicity = 45% (70% in cluster)
38
Describe SUNCT
Attack frequency: -3-200 (1-8 in cluster) Duration: 5-240 seconds (15-180 mins in cluster) Pain quality: -stabbing, burning (sharp, throbbing in cluster) Pain intensity: very severe (same as cluster) No circadian periodicity
39
What is paroxysmal hemicrania?
Pain = mainly orbital and temporal, UNILATERAL, rapid onset, 2-20 mins, rapid cessation of pain Prominent ipsilateral autonomic symptoms 10% attacks can be preceiptated by BENDING OR ROTATING HEAD
40
What is the treatment for Paroxysmal hemicrania?
Absolute response to indometacin as a prophylactic treatment
41
Describe SUNCT
Unilateral orbital, supraorbital or temporal pain which is stabbing or pulsating 10-240 seconds duration Attack frequency = 3-200 per day, no refractory period Pain accompanied by conjunctival injection and lacrimation
42
How does the pain differ in SUNCT?
Stabbing or pulsating pain may be single stabs, group of stabs or have a sawtooth pattern
43
What are the cutaneous triggers for SUNCT?
Wind, cold Touch Chewing
44
What is trigeminal neuralgia?
Unilateral maxillary or mandibular division pain > opthalmic division Stabbing pain of a single or multiple stabs 5-10 sec duration Attack frequency similar to SUNCT, has refractory period Autonomic features uncommon
45
What is the abortive treatment for a cluster headache?
SC Sumatriptan 6mg or nasal zolmatriptan 5mg 100% oxygen
46
What is the abortive treatment for a bout of cluster headaches?
Occipital depomedrone injection (same side as the headache) | Or tapering course of oral prednisolone
47
What is the preventative medication in cluster headache?
- Verapamil (high doses possibly) - Lithium - Methysergide (risk of retroperitoneal fibrosis) - Topiramate
48
What is the abortive treatment in paroxysmal hemicrania?
No abortive treatment only prophylactic
49
What is the treatment for SUNCT/SUNA?
No abortive treatment Prophylaxis - Lamotrigine - Topiramate - Gabapentin - Carbamazepine
50
What is the treatment in Trigeminal Neuralgia?
No abortive Prophylaxis: - Carbamazepine - Oxcarbazepine Surgical Intervention: - Glycerol ganglion injection - Steriotactic radiosurgery - Decompressive surgery
51
What presentations of headache are more likely to have a sinister cause?
- Associated head trauma - First or worst headache - Sudden (thunderclap) onset - New daily persistent headache - Change in headache pattern or type - Returning patient (keeps getting worse)
52
What are some of the red flags in headache?
New onset headache New or change in headache: - aged over 50 - Immunosupression or cancer Change in headache frequency, characteristics or associated symptoms - Focal neurological symptoms - Non-focal neurological symptoms - Abnormal neurological examination Neck stiffness/ fever high pressure Low pressure Giant cell arthritis
53
What are the signs of high intracranial pressure in headache?
- Headache worse when lying down - Headache wakening patient up - Headache precipitated by physical exertion - Headache precipitated by valsalva manoeuvre - Risk factors for cerebral venous sinus thrombosis
54
What are the signs of low intracranial pressure in headache?
Headache precipitated by sitting/standing up
55
What are the signs of Giant Cell Artiritis
Jaw claudication or visual disturbance Prominent or beaded temporal arteries More common in 70's/80's
56
What is a thunderclap headache?
A high intensity headache reaching maximum intensity in less than 1 minute Majority are peak intensity May be primary or secondary although no differentiating features
57
What is the differential diagnosis of thunderclas headache?
- Subarachnoid haemorrhage - Intracerebral haemorrhage - TIA/Stroke - Carotid/ vertebral dissection - Cerebral venous sinus thrombosis - Meningitis/ encephalitis - Pituitary apoplexy - Spontaneous intracranial hypotension
58
How many patients with a thunderclap headache are having a subarachnoid haemorrhage?
1 in 10
59
Who should you act on when especially suspect a SAH in?
All patients presenting with a sudden severe headache that peaks within a few minutes and lasts for at least 1 hour Examination is often normal Never consider a patient "too well" for SAH
60
How do you treat someone with suspected SAH?
SAME DAY hospital assessment CT brain Lumbar Puncture (must be done >12 hours after headache onset) CT +/- LP is unreliable beyond 2 weeks and angiography is required beyond this time
61
When should CNS infection be considered?
Any patient presenting with headache and fever
62
How to spot meningism?
Nausea +/- vomiting, photo/phono-phobia, stiff neck look for a rash
63
How to spot encephalitis?
Altered mental state/ consciousness Focal symptoms/ signs Seizures Look for a rash
64
How do you investigate Intracranial Hypotension?
MRI brain and spine
65
WHat is the treatment for Intracranial hypotension?
Bed rest, fluids, analgesia, caffeine (red bull) IV caffeine EPIDURAL BLOOD PATCH
66
What is giant cell arteritis?
Arteritis of large arteries (on spectrum with polymyalgia rheumatica) Should be considered in any patient over the age of 50 presenting with new headache
67
What are the symptoms and signs of giant cell arteritis?
Headache usually diffuse, persistant and may be severe. Patient mey be systemically unwell. Specific features include scalp tenderness, jaw claudication and visual disturbance. Prominent, beaded or enlarged temporal arteries may be present
68
What investigations can you perform to confirm Giant Cell Artiritis?
An elevated ESR supports diagnosis (usually >50, often much higher, rarely normal) Raised CRP and platelet count are other useful markers
69
What is the course of action if giant cell arteritis is the likely diagnosis?
High dose prednisolone should be started and a temporal artery biopsy arranged