Headaches Flashcards

(57 cards)

1
Q

Red flags for headaches

A

First or worst

Abrupt onset

Fundamental pattern change

New headache pattern when

– ≤5 years old

– ≥50 years old

Cancer, HIV, pregnancy

Abnormal physical exam

Neuro symptoms ≥ one hour

Headache onset:

– with seizure or syncope

– with exertion, sex or valsalva

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2
Q

Comfort signs for headache

A

Normal physical exam

Stable pattern
Long-standing history
Family history of similar headaches

Consistently triggered by:

– Hormonal cycle

– Specific foods

– Specific sensory input: Light or Odors

– Weather changes

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3
Q

large meta-analysis reports that 0.18% of patients with migraine and normal Neurologic

exam will have significant intracranial pathology, this means

A

we have Secondary headaches that are a presentation of something else, make sure to do proper workup of headahe

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4
Q

Headache is idiopathic with no identifiable underlying pathology

No diagnostic test

Defined by clinical symptomatology

Diagnosis based on ruling out pathology

A

Primary Headache

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5
Q
  • Headache is symptom reflecting underlying pathology
  • Diagnostic tests available
  • Diagnosis based on defining pathology
A

Secondary headache

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6
Q

Causes of Primary headache

A
  • Migraine
  • Cluster
  • Tension-type
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7
Q

Causes of secondary headache

A
  • Traumatic (e.g. TBI) • Vascular (e.g. SAH) • Infectious (e.g. sinusitis)
  • Metabolic (e.g. CO poisoning)
  • Oncologic – Primary – Secondary
  • Inflammatory (e.g. Giant Cell Arteritis)
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8
Q

What do all the below structures have in common?

Meningeal arteries
Proximal portions of the cerebral arteries

Dura at the base of the brain
Venous sinuses
Cranial nerves 5, 7, 9, and 10, and cervical nerves 1, 2, and 3

A

Pain sensitive intracranial structures

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9
Q

Pt comes in with recurrent migraines, normally DO NOT get CT or MRI unless:

A

– Recent change in headache pattern

– New onset seizures
– Focal neurologic signs or symptoms

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10
Q

____of Headache Seen in Primary Care Practices (PCP) Medical Offices is Migraine and ____of Patients in PCP Waiting Rooms have Migraine with _____ of migraneurs undiagnosed

A

~75%

33%

50%

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11
Q

_____ Women has Migraines
____ Households has a Migraine Sufferer

A

1 in 5

1 in 4

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12
Q

These types of headaches are brief: may see 1 every other day up to 8 per day and are SEVERE, Unilateral orbital/supraorbital/temrporal and last 15-180 mins

A

Cluster headaches

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13
Q

Cluster headaches have characteristic UNIlateral orbital/supra/temporal headahce for 15-180 mins and one of which types of symptoms

A

Conjucntival injection, miosis, ptosis, lacrimation, eyelid edema, rhinorrhea, congestion, forehead/face swelling

so bacially weird eye/nose/face stuff

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14
Q

We may see pain around one eye, along with drooping lid and tearing or conjestion on same side as pain

A

Horner sydrome associated with Cluster headaches

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15
Q

To be Dx with headaches without aura, you must have at least 5 of them, they last 4-72 hrs and have two of the following:

A

unilateral location

pulsating quality

moderate or severe intensity

aggravated by walking up stairs/physical activity

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16
Q

You must have at least ONE associated symptom to have dx of migraine w/out auras. These are:

A

Nausea

vomitting

photophobia/phonophobia

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17
Q

What three features are most predictive of diagnosis with migraines

A

Nausea

disability

photophobia

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18
Q

What is a fortification specra with partial scotoma

A

fancy way to describe aura that sometimes preceeds migraines

last 15-20 mins, sometimes see brief seizures; all aura have + visual elements thus its a HYPERexcitable state

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19
Q

To be Dx with tension-type headaches, you must have a head that lasts

A

hours or may be continous

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20
Q

We need two descriptors of tension headaches to dx; what are they?

A
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21
Q

What associated findings are seen in tension headaches?

A

no more then ONE!!!

photo/phonophobia

mild nausea

**no moderate or severe nausea nor vomitting

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22
Q

Weird way to describe tension headache

A

 Stress as associated event
 Location: Tension Headache as Premonitory Symptom
If neck pain 82% get Tension Headache diagnosis
75% reported neck pain with their migraine
 43% described neck pain as bilateral and 57% as unilateral
 69% described the neck pain as “tightness” and 17% as “stiffness”

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23
Q

How does someone truly suffer from sinus headache?

A

need to have fully filled sinus and congestion

**migrains will cause nasal stuffiness and pressure before treatment

*people may think they have sinus headache when it is migrain and will experience some symptom relief from decongestants bc tx syptoms of migraine

24
Q

What do we need to consider when dx sinus headache

A

location, autonomic symptoms, weather as trigger and OTC advertisement

25
Non modifiable risk facotrs for chronic daily headache
migrain female sex (estrogen) low education low socioeconmic class head injury
26
What are MODIFIABLE risk factors for chronic daily headaches
Attack frequency Obesity Medication overuse Stressful life events Snoring (sleep apnea, sleep disturbance)
27
42 year old male presents with complaint of sinus headache Current headache problem has been recurrent every night waking patient from sleep Pain is in left eye and feels “like a dagger” Has intense nasal congestion leading to rhinorreha as well as a red eye that tears profusely. Pain last 30 minutes. He thinks nasal sprays help * He had similar headaches last December which went away after a month on antibiotics. * His PMH/PSH/FH are unremarkable. He drinks socially but has stopped since these headaches began because of “hangover” as soon as he imbibes. * PE: unrmarkable, no intranasal findings, no percsussion tenderness correct dx??
CLUSTER headaches
28
* 31 year old female presents with complaint of headaches that “won’t go away” * Had occasional headaches like these for years. Never “big deal” as came and went and rarely required medicine. * 6 months ago the headaches became increasingly frequent and longer lasting until they became constant. * Denies any other symptoms with these headaches * PMH/PSH/FH unremarkable. SH-began working for EPIC 7 months ago. * ROS: has developed insomnia and “too tired” to go out with friends or exercise. OTC meds afford no relief. Sometimes a glass of wine seems to help. Exam: Negative except for subocciptial tenderness and increased muscle tension in Trapezius and Cervical Paraspinal muscles DX
chronic tension type headache
29
Proposed mechanism for Migraine initiation
Genetic susceptibility Cortical neuronal hyperexcitability/// abnormal brainstem fnx
30
What leads to cortical spinal depression which causes Actvation and peripheral sensitization of TGVS
Cortical neuralonal excitability cauases cortical spinal depression (which can lead to aura)
31
What plays a role in pain generation/perpetuation in headaches
Neurogenic inflammation and central sensitization as a result of TGVS activation and sensitizaiton (from corical spinal depresion)
32
Mechanism for Hyperexcitability
• **Enhanced release** of excitatory neurotransmitters – For example, **elevated plasma glutamate** concentration in patients with migraine – Identified genetic m**utations in Familial Hemiplegic Migraine (FHM)** • Reduced intracortical inhibition **Low brain Mg2+** Altered brain energy metabolism
33
Initiating Mechanisms of Headache Pain: Cortical Spreading Depression
 Wave of intense cortical neuron activity – ↑rCBF  Followed by neuronal suppression – ↓rCBF – Often coincides with headache onset
34
What is responsible for Activation of the Trigeminovascular System and Pain Generation
Cortical spreading depression: releases AA, NO, H+ and K+ to meninges get sensitized pain respons adn dilation of vessels
35
Initiating Mechanisms of Migraine: Brainstem Dysfunction
Dysfunction in areas involved in **central control of nociception \*\*\*** PAG Induces migraine? \*\*\*\*Brainstem generator Facilitates activation and sensitization of TNC neurons? \*\*\*\* Decreased descending inhibition during a migraine attack
36
Migraines can be a result of brainstem dysfnx What facilitates activation and sensitization of TNC neurons?
\*\*\*\* Decreased descending inhibition during a migraine attack
37
Abortive Pharm for migraines
Triptans = Key for Abortive: includes Seratonin/ CGRP and Neurotransmission= major class Hormonal manipulation: such as estrogen and NSAIDS
38
Mechanism of Triptans
Seratonin 1B/1D agonist, ≠release of vasoactive peptides such as CGRP, promte vasocnx, ≠brstm pain path, ≠trigeminal nucleus caudalis
39
Side effects of Triptans
Sides = periph vasocnx/ nauseua/vomit/angina/flush/dizzy Contraindication:stroke and MI, uncontrolled HTN, ischemic heart disease
40
Prophy drugs for migraines
TCA, Beta Blockers, anti-seizure agents, BP type drugs, estrogens
41
TCAs used to treated migraines prophylactically
Amitryptyline, Nortirptyline
42
Facilitate sleep; sedating. Are anticholinergic and effective for many pain sources; Block reuptake of serotonin and Nepi
Amitryptyline, Nortirptyline TCAs
43
Divalproex Sodium and Valpoic Acid, Topiramte
Anti-seizure meds to proph tx migraines
44
Vasoactivce compounds use to proph tx migraines
Beta blockers: Propranolol, Atenolol = A level and very effective Ca+ channel blockers: verapamil, Dlitazem; possibly effective
45
Serotonin formation
Tryptophan --\>(tryptophan hydroxylase as RLS)--\>--\> serotonin. Trypto.hydroxlase needs O2 and reduced pteridine cofactor; also limited by tryptophan entry into brain
46
Serotonin reactivation:
Active reuptake via SERT/ metabolized to 5-hyroxoindole acetic acid via MAO and converted to melatonin in pineal gland via hydorxindole-O-methyl transferase
47
Serotonin dispersment in the body
90% in GI system—some in neurons, 8% in plats and 2% in CNS; midbrain raphe nucleus projects all over brain; turnover w/in 4 hours
48
Descirbe Serotonin Receptors
Most GCPR except 5HT3 = ligand gated Cation channel
49
Inhibition of adenlyate cyclase; 5-HT1a also opens K+ channels
5HT-1a-e
50
Serotonin R that works via PI hydrolysis
5-HT2 (a-c)
51
Serotonin R that works via: Activation of adenylate cyclase or unknown
5-HT 4-7
52
Auto receptors that Decrease serotonin release
: 1A and 1D like
53
Serotonin effecs on CV system
Potent vasoCNX of large art/vns; cranial 5-HT1D blood vessels vasoDIALATIOn in coronary, skeletal msl, cutaneous Bezold-Jarish reflex = coronar chemoR; lead to hypotension, hypovent, brady Plat aggregation: active uptake serotonin from circulation by plats
54
Serotonin and CNS system
NTs: cell body in midbrain raphe nuclei project rostrally and caudally Sensory perception/slow wave sleep/temp regulation/neuroendo= ACTH,GH, prolact,TSH,FSH,LH release/ learning+memory + short term/ pain perception/ drug abuse
55
\_\_\_\_\_= emisis receptors Has mental illness implications; anxiety =\_\_\_\_\_\_
5-HT3 = 5-HT1A
56
5-HT1A partial agonist for antianxiety
buspirone
57
5-HT1B/D receptor on cerebral BV to tx migraines and stop exsisting
Sumatriptan